Biophysical Society 61st Annual Meeting | Program Guide

93-Plat 9:45 am FUNCTIONAL EFFECT OF HUMAN FXYD2, FXYD4, FXYD6, AND FXYD7 ON HUMAN ALPHA 1 BETA 1 SODIUM-POTASSIUM ATPASE.  Sharan Bijlani , Natalia Armas Capote, Grace Shim, Dylan Meyer, Pablo Artigas 94-Plat 10:00 am THE ENERGY-TRANSDUCTION DOMAIN OF THE SERCA CALCIUM PUMP IS A PRIME THERAPEUTIC TARGET IN HEART FAILURE AND OBESITY.  Joseph M. Autry , Michel Espinoza-Fonseca, Bengt Svensson, Christine B. Karim, Stephanie J. Valberg, John K. Lee, David D. Thomas Platform

103-Plat 8:15 am SUPER-RESOLUTION IMAGING OF UNLABELED PROTEINS ON DNA.  Anna EC Meijering , Andreas S. Biebricher, Erwin JG Peterman, Gijs JL Wuite, Iddo Heller 104-Plat 8:30 am VARYING LABEL DENSITY TO PROBE MEMBRANE PROTEIN NANOCLUS- TERS IN STORM/PALM.  Florian Baumgart, Andreas Arnold, Konrad Les- kovar, Kaj Staszek, Martin Foelser, Julian Weghuber, Hannes Stockinger, Gerhard J. Schuetz 105-Plat 8:45 am TRACKING OLIGOMERIC TRANSCRIPTION FACTOR DYNAMICS BY PAIR CORRELATION OF MOLECULAR BRIGHTNESS (PCOMB).  Elizabeth Hinde , Elvis Pandzic, Zhengmin Yang, Ivan Ng, Marie Bogoyevitch, David Jans, Enrico Gratton, Katharina Gaus 106-Plat 9:00 am RECONSTRUCTING SPATIAL FEATURES OF NUCLEOCYTOPLASMIC TRANS- PORT USING PROJECTED CARGO LOCALIZATIONS.  Li-Chun Tu, Maximiliaan Huisman , Yu-Chieh Chung, Carlas Smith, David Grunwald 107-Plat 9:15 am International Travel Awardee FOLLOWING A GIANT’S FOOTSTEPS: SINGLE-PARTICLE AND SUPER- RESOLUTION APPROACHES TO DECIPHER THE NUCLEAR TRANSPORT OF HEPATITIS B VIRUS CAPSIDS.  Giulia Paci , Niccolò Banterle, Christine Koehler, Edward A. Lemke 108-Plat 9:30 am DEVELOPMENT OF A SIMULTANEOUS SIX-COLOR FLUORESCENCE MI- CROSCOPE WITH SINGLE-MOLECULE SENSITIVITY.  Jingyu Wang , Jamie Barnett, Luke Springall, Neil M. Kad 109-Plat 9:45 am INTRACELLULAR DELIVERY OF MEMBRANE IMPERMEABLE PHOTOSTABLE FLUORESCENT PROBES INTO LIVING CELLS FOR SUPER-RESOLUTION MICROSCOPY.  Yuji Ishitsuka , Kai Wen Teng, Pin Ren, Yeoan Youn, Xiang Deng, Pinghua Ge, Andrew Belmont, Paul R. Selvin 110-Plat 10:00 am BRIGHT AND PHOTOSTABLE FLUOROPHORES FOR ADVANCED FLUORESCENCE MICROSCOPY.  Qinsi Zheng , Jonathan B. Grimm, Anand K. Muthusamy, Robert H. Singer, Luke D. Lavis Platform Membrane Protein Structures I 8:15 am - 10:15 am, Room R08/09 Co-Chairs Robert Stroud, University of California, San Francisco Nathaniel Traaseth, New York University 111-Plat 8:15 am STRUCTURE INHIBITION AND REGULATION OF A TWO-PORE CHANNEL TPC1.  Alexander F. Kintzer , Robert M. Stroud 112-Plat 8:30 am NOVEL MECHANISM OF GATING IN THE TRKH-TRKA COMPLEX.  Hanzhi Zhang , Zhao Wang, Mingqiang Rong, Yaping Pan, Wah Chiu, Ming Zhou 113-Plat 8:45 am STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OF A CALCIUM- ACTIVATED CATION CHANNEL FROM TSUKAMURELLA PAUROMETABOLA .  Bala Dhakshnamoorthy, Ahmed Rohaim , Huan Rui, Lydia Blachowicz, Benoit Roux 114-Plat 9:00 am Education Travel Awardee CRYSTAL STRUCTURE OF A LOW CO 2 -INDUCIBLE PROTEIN, LCI1 IN CHLAMYDOMONAS REINHARDTII .  Tsung-Han Chou

F R I D A Y

S U N D A Y

Voltage-gated Na Channels 8:15 am - 10:15 am, Room R04/05

Co-Chairs Shana L. Geffeney, Utah State University Jesse B. Yoder, Johns Hopkins University 95-Plat 8:15 am

TETRODOTOXIN RESISTANCE: NATURAL EXPERIMENTS TO UNDERSTAND VOLTAGE-GATED SODIUM CHANNEL STRUCTURE AND FUNCTION.  Shana L. Geffeney , Gabriela Toledo, Charles T. Hanifin 96-Plat 8:30 am USING SPECIFIC BLOCKERS TO IDENTIFY TTX-S NA V CHANNELS SUBTYPES IN RAT MUSCLE AFFERENT NEURONS.  Renuka Ramachandra , Keith S. 8:45 am MULTIPLE MECHANISMS OF PROPOFOL INHIBITION OF THE VOLTAGE- GATED SODIUM CHANNEL NACHBAC: A 19 F NMR INVESTIGATION.  Yali Wang , Marta M. Wells, William Dailey, Roderic Eckenhoff, Pei Tang, 9:00 am THE COMPLETE CRYSTAL STRUCTURE OF AN OPEN ACTIVATED SODIUM CHANNEL.  Jennifer Booker , Altin Sula, Claire E. Naylor, B.A. Wallace 99-Plat 9:15 am THE CARDIAC CHANNEL NA V 1.5 INACTIVATION IS MODULATED BY ITS C-TERMINAL EF-HAND DOMAIN.  Bernd R. Gardill , Ching-Chieh Tung, Ricardo E. Rivera-Acevedo, Filip Van Petegem 100-Plat 9:30 am TRANSGENIC APPROACH TO EXPLORATION OF CALMODULIN’S ROLE ON SODIUM CHANNEL FUNCTION WITHIN CARDIOMYOCYTES.  Jeffrey Abrams , Alexander Katchman, Lin Yang, Steven Marx 101-Plat 9:45 am INVESTIGATING CA 2+ -DEPENDENT REGULATION OF SODIUM CHANNELS VIA THERMODYNAMIC AND STRUCTURAL ANALYSIS OF NAV1.4 AND NAV1.5 CARBOXY TAIL INTERACTIONS WITH CALMODULIN.  Jesse B. Yoder , Sandra B. Gabelli, L. Mario Amzel 102-Plat 10:00 am TARGETING THE CARDIAC SODIUM CHANNEL TO INCREASE EXCITABILITY OF STEM-CELL DERIVED CARDIOMYOCYTES.  Valentin Sottas , Cristian Mihnea Trache, Nina D. Ullrich Platform Optical Microscopy and Super-Resolution Imaging: Novel Approaches and Analysis I 8:15 am - 10:15 am, Room R06/07 Co-Chairs Gerhard Schuetz, Vienna University of Technology, Austria Elizabeth Hinde, University of New South Wales, Australia Elmslie 97-Plat Yan Xu 98-Plat

13