Biophysical Society 61st Annual Meeting | Program Guide

Platform Cardiac Muscle Regulation 1:00 pm - 3:00 pm, Room R08/09

2379-Plat 1:15 pm IMPROVEMENTS OF THE KINETICS OF RED FLUORESCENT CALCIUM INDI- CATORS.  Silke Kerruth , Catherine Coates, Katalin Torok 2380-Plat 1:30 pm PARTICLE-BASED APPROACHES TO CLEARING CALCIUM: A PROTEIN LAND- SCAPE MODEL OF THE SARCO/ENDOPLASMIC RETICULUM CALCIUM- ATPASE (SERCA) PUMP FOR SUB-CELLULAR STOCHASTIC MODELS.  Sophia P. Hirakis , Thomas M. Bartol, Terrence J. Sejnowski, Rommie E. Amaro 2381-Plat 1:45 pm CA 2+ SIGNALS ORIGINATE FROM IMMOBILE IP 3 RECEPTORS AT ER-PM JUNCTIONS.  Nagendra Babu Thillaiappan , Alap P. Chavda, Stephen C. Tovey, David L. Prole, Colin W. Taylor 2382-Plat 2:00 pm CHARACTERIZATION OF DIFFERENT LOCALIZED CA 2+ SIGNALS IN SKELETAL MUSCLE FIBERS. Mikhail Svirin , Tihomir Georgiev, Enrique Pérez Jaimov- ich, Rainer H A Fink 2383-Plat 2:15 pm ROLE OF ORAI PROTEINS IN ACTIVATION OF ENDOGENOUS TRPC1-COM- POSED CHANNELS.  Alexey Shalygin , Anton Skopin, Dmitrii Kolesnikov, Lyubov Glushankova, Elena Kaznacheyeva 2384-Plat 2:30 pm THE TWO-PORE DOMAIN K + CHANNEL TALK-1 PROVIDES A COUNTERCUR- RENT THAT FACILITATES ENDOPLASMIC RETICULUM CA 2+ LEAK.  Nicholas Vierra , Prasanna Dadi, Sarah Milian, David Jacobson 2385-Plat 2:45 pm SAFETY UPGRADES OF THE MITOCHONDRIAL CALCIUM UNIPORTER.  Ming-Feng Tsai , Christopher Miller Platform Protein Structure and Conformation III 1:00 pm - 3:00 pm, Room 208/209 Co-Chairs Nathan S. Babcock, Simon Fraser University, Canada Michael Nilges, Pasteur Institute, France 2386-Plat 1:00 pm CPOW Travel Awardee TRAPPING ON-PATHWAY INTERMEDIATES FOR LARGE SCALE CONFORMA- TIONAL CHANGES WITH COARSE-GRAINED SIMULATIONS.  Laura Orellana , Özge Yoluk, Oliver Carrillo, Modesto Orozco, Erik Lindahl 2387-Plat 1:15 pm STUDYING BIOMOLECULAR INTERACTIONS: A HYBRID APPROACH.  Sean A. McKenna, Manuel Koch, Janusz M. Bujnicki, Joerg Stetefeld, Trushar R. Patel 2388-Plat 1:30 pm THE MOLTEN GLOBULE STATE OF MALTOSE BINDING PROTEIN: STRUC- TURAL CHARACTERIZATION BY EPR SPECTROSCOPY.  Benjamin Selmke, Chen Nickolaus, Peter Borbat, Jack H. Freed, Wolfgang E. Trommer 2389-Plat 1:45 pm MODEL COMPARISON TO IDENTIFY STRUCTURAL HETEROGENEITY IN PROTEIN X-RAY CRYSTALLOGRAPHY.  Nathan S. Babcock , David A. Sivak, Daniel Keedy, James S. Fraser 2390-Plat 2:00 pm SINGLE MOLECULE IDENTIFICATION AGAINST PROTEOMES USING SUB- NANOMETER PORES.  Eamonn Kennedy , Mikhail Kolmogorov, Zhuxin Dong, Pavel Pevzner, Greg Timp

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Co-Chairs Paul Janssen, The Ohio State University Gaetano Santulli, Columbia University 2370-Plat 1:00 pm

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CARDIAC EXCITABILITY AT THE INTERCALATED DISC IS MAINTAINED VIA A SMALL ISOFORM OF OBSCURIN.  Heather R. Manring , Maegen A. Ackermann 2371-Plat 1:15 pm CONTRACTILE FORCE AND KINETICS IN FAILING VERSUS NON-FAILING HUMAN MYOCARDIUM.  Jae-Hoon Chung, Brit Martin, Benjamin Canan, Mohammad Elnakish, Nancy Saad, Ahmet Kilic, Mei-Pian Chen, Nima Milani-Nejad, Peter Mohler, Vadim Fedorov, Paul Janssen 2372-Plat 1:30 pm ADAPTIVE VENTRICULAR REMODELLING AFTER MYOCARDIAL INFARC- TION INVOLVES TITIN-BASED CARDIOMYOCYTE STIFFENING AND EL- EVATED TITIN TURNOVER.  Sebastian Kötter , Malgorzata Kazmierowska, Christian Andresen, Katharina Bottermann, Maria Grandoch, Simone Gorressen, Andre Heinen, Jens M. Moll, Jürgen Scheller, Axel Gödecke, Jens W. Fischer, Joachim P. Schmitt, Martina Krüger 2373-Plat 1:45 pm MECHANISTIC ROLE OF TYPE 1 INOSITOL 1,4,5-TRISPHOSPHATE RE- CEPTOR IN THE REGULATION OF VASCULAR TONE IN HEART FAILURE.  Gaetano Santulli , Jessica Gambardella, Steven Reiken, Qi Yuan, Ryutaro Nakashima, Frances M. Forrester, Alain Lacampagne, AndrewMarks 2374-Plat 2:00 pm TROPONIN I TYROSINE PHOSPHORYLATION MODULATES CARDIAC CONTRACTION.  Elizabeth A. Brundage, Vikram Shettigar, Hussam E. Salhi, Jonathan P. Davis, Mark T. Ziolo, Brandon Biesiadecki 2375-Plat 2:15 pm ACETYLATION OF K326 AND K328 ON ACTIN BOOSTS CONTRACTILE PROPERTIES OF MUSCLE IN VITRO AND IN VIVO . William Schmidt , Meera C. Viswanathan, D. Brian Foster, Anthony Cammarato 2376-Plat 2:30 pm DIRECT SINGLE MOLECULE VISUALIZATION OF CARDIAC MYBP-C N-TER- MINAL FRAGMENT INTERACTIONS WITH SUSPENDED THIN FILAMENTS.  Alessio V. Inchingolo , Michael J. Previs, Samantha E. Beck Previs, Neil M. Kad, David M. Warshaw 2377-Plat 2:45 pm THE ROLE OF METHYLGLYOXAL ON THE CARDIAC MYOFILAMENT. Maria Papadaki , Ronald Holewinski, Marisa Stachowski, Jonathan Kirk Platform Calcium Signaling/Intercellular Calcium Channels and Sparks and Waves 1:00 pm - 3:00 pm, Room 206/207 Co-Chairs

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Ming-Feng Tsai, Brandeis University David Jacobson, Vanderbilt University 2378-Plat 1:00 pm

HIGH-THROUGHPUT SCREENS TO DISCOVER INHIBITORS OF LEAKY RYANODINE RECEPTOR CALCIUM CHANNELS.  Robyn T. Rebbeck, Megan V. Ryan, Gregory D. Gillispie, David D. Thomas, Donald M. Bers, Razvan L. Cornea

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