Biophysical Society 61st Annual Meeting | Program Guide

2433-Pos Board B40 MOLECULAR RECOGNITION MECHANISM OF HEMATOPOIETIC PROSTA- GLANDIN D SYNTHASE WITH ITS COFACTOR AND SUBSTRATE. Keisuke Asada , Shigeru Shimamoto, Tomohiro Oonoki, Takahiro Maruno, Yuji Kobayashi, Kosuke Aritake, Yoshihiro Urade, Yuji Hidaka 2434-Pos Board B41 LIPOCALIN-TYPE PROSTAGLANDIN D SYNTHASE POSSESSES TWO BINDING SITES FOR ITS PRODUCT. Shigeru Shimamoto , Yusuke Nakagawa, Takahiro Maruno, Yuji Kobayashi, Kosuke Aritake, Urade Yoshihiro, Yuji Hidaka 2435-Pos Board B42 STRUCTURAL, THERMODYNAMIC AND PHOSPHATIDYLINOSITOL 3-PHOS- PHATE BINDING PROPERTIES OF PHAFIN2. Tuo-Xian Tang 2436-Pos Board B43 TARGETING MICROTUBULES IN LEISHMANIA USING A COMBINED COM- PUTATIONAL & EXPERIMENTAL APPROACH. Andrew Kalenkiewicz , Phil Cruz, Michael Dolan, Dan L. Sackett 2437-Pos Board B44 EFFECTS OF AZOLE DRUGS ON CONFORMATIONAL DYNAMICS AND ENERGETICS ASSOCI- ATED WITH DIATOMIC LIGAND PHOTORELEASE AND MIGRATION WITHIN BACTERIAL FLAVOHEMO- GLOBINS. David Butcher , MyriamMoussaoui, Laura Baciou, Jaroslava Miksovska 2438-Pos Board B45 AN EFFICIENT PROTEIN SYSTEM FOR SCREENING SPECIFIC MDMX AND MDM2 INHIBITORS. Rong Chen , Jingjing Zhou, Lingyun Qin, Zhengding Su 2439-Pos Board B46 LIGAND BINDING STUDIES OF A PLASMID ENCODED DIHYDROFOLATE REDUCTASE BY 19 F NMR BINDING STUDIES OF A PLASMID ENCODED DIHYDROFOLATE REDUCTASE BY 19 F NMR. Gabriel J. Fuente Gomez , MICHAEL DUFF, Elizabeth Howell Protein Dynamics and Allostery IV (Boards B47–B64) 2440-Pos Board B47 MECHANISM OF ALLOSTERIC REGULATION OF SUBSTRATE SPECIFICITY IN PROTEIN KINASE C. Nagarajan Vaidehi , Hyun Deok Song, Titu Devamani, Ruth Sommese, Sivaraj Sivaramakrishnan 2441-Pos Board B48 REGULATION OF PROTEASOMAL CATALYTIC ACTIVITY BY ALTERING ITS PROTEIN-PROTEIN INTERACTIONS. Pawel A. Osmulski , Przemyslaw Kar- powicz, Matthew B. Giletto, Corey L. Jones, Kristin E. Cano, Dmitri Ivanov, Tim H. Huang, Elzbieta Jankowska, Jetze Tepe, Maria Gaczynska 2442-Pos Board B49 INCORPORATION OF MULTI-STATE INFORMATION IMPROVES MO- LECULAR MODELLING OF DYNAMIC ALLOSTERY: A CASE STUDY OF PDZ DOMAINS COMPUTATIONAL QUANTITATIVE CHARACTERIZATION OF EN- TROPIC SIGNALING PATHWAYS IN PROTEINS: A CASE STUDY ON HUMAN PDZ2 DOMAIN OF PTP1E. Mohsen Botlani , Sameer Varma 2443-Pos Board B50 DYNAMICAL MECHANISMS OF ALLOSTERIC MODULATIONS BY SMALL MOLECULES ON LEUKOCYTE FUNCTION-ASSOCIATED ANTIGEN-1.  Jung-Hsin Lin 2444-Pos Board B51 THE STRUCTURAL AND DYNAMIC EFFECTS OF INHIBITOR BINDING TO PROTEIN KINASE C ΒII. Shashank Jariwala , Sivaraj Sivaramakrishnan, Barry J. Grant

2420-Pos Board B27 METASTABILITIES IN THE HUMAN PRION PROTEIN N-TERMINAL BETA- SHEET ARE DICTATED BY THE 129 POLYMORPHISM. S. Alexis Paz, Eric Vanden-Eijnden, Cameron Abrams 2421-Pos Board B28 DEFECTIVE AXONAL TRANSPORT AND ALZHEIMER’S DISEASE CORRELA- TIONS: A MOLECULAR MOTOR POINT OF VIEW. Marcelo Nakaema 2422-Pos Board B29 CHARACTERIZATION OF HUMAN IGG1 FC REGION STABILITY AND AGGRE- GATION PROPENSITY. Evan A. Wells , Anne S. Robinson 2423-Pos Board B30 UTILISING FLUORESCENCE MICROSCOPY TO VISUALISE THE DY- NAMICS AND INTERACTIONS OF MOLECULAR CHAPERONES AND Α-SYNUCLEIN. Quill Bowden , Alex MacMillan, Tobias Rosenkranz, Till Böcking Protein-Small Molecule Interactions II (Boards B31–B46) 2424-Pos Board B31 BIOMOLECULAR INTERACTION DETERMINATION AND QUANTIFICATION BY MICROSCALE THERMOPHORESIS. Wyatt Strutz , Govind Shah 2425-Pos Board B32 DOES THE PRESENCE OF A CO-SOLVENT ALTER THE AFFINITY OF A HYDROPHOBIC DRUG TO ITS TARGET? Caroline Senac , Patrick Fuchs, Wladimir Urbach, Nicolas Taulier 2426-Pos Board B33 CONVENIENT BIOLOGICAL INTERACTION ANALYSIS WITH A REGENERA- TIVE STREPTAVIDIN CHIP. Lukas Traxler , Claudia Knoglinger, Kristyna Posledni, Andreas Zich, Bianca Ruttmann, Gloria Friedl, Peter Hinterdor- fer, Hermann J. Gruber 2427-Pos Board B34 PORPHYRIN INDUCED MULTIMERIZATION OF SOLUTION-STATE PRO- TEINS. Daniel R. Marzolf , Coleman M. Swaim, Aidan M. McKenzie, Chris- topher A. Hudson, Nathan T. Wright, Oleksandr Kokhan 2428-Pos Board B35 IN SILICO DISCOVERY OF A PROTEIN-PROTEIN INTERACTION INHIBITOR FOR INFLUENZA VIRUSES. Gregory Mohl , David Busath 2429-Pos Board B36 BINDING OF ANTIBIOTICS TO THE MULTIDRUG EFFLUX PUMP ACRB OF E. COLI INVESTIGATED BY MOLECULAR DOCKING. Giuliano Malloci , Giovanni Serra, Andrea Bosin, Attilio Vittorio Vargiu, Paolo Ruggerone 2430-Pos Board B37 EXPLORING FOLATE-SMALL MOLECULE INTERACTIONS IN BACTERIAL CELLS. Deepika K. Nambiar , Robert Shew, Bryan Schwarz, Michael Duff, Timkhite Kulu-Berhane, Elizabeth Howell 2431-Pos Board B38 ATTENUATING THE TOXICITY OF AMYLOID-BETA AGGREGATION WITH SPECIFIC SPECIES. Ryan Limbocker , Benedetta Mannini, Michele Perni, Sean Chia, Gabriella Heller, Francesco S. Ruggeri, Johnny Habchi, Georg Meisl, Pavan K. Challa, Michael Zasloff, Tuomas P. J. Knowles, Michele Vendruscolo, Christopher M. Dobson 2432-Pos Board B39 DETERMINATION OF LIGAND MIGRATION PATHWAYS IN HUMAN CYTO- GLOBIN. Antonija Tangar , Michael Goncalves, Sophie Bernad, Valerie Derrien, Pierre Sebban, Jaroslava Miksovska

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