Biophysical Society 61st Annual Meeting | Program Guide

2696-Pos Board B303 IPSC-DERIVED NEURONS HARBORING A KNOWN EPILEPSY MUTA- TION DISPLAY KNOWN AND NOVEL ELECTROPHYSIOLOGICAL PHENO- TYPES. Coby Carlson, Imran Quaraishi, Yalan Zhang, Michael McLachlan, Benjamin Meline, Chris McMahon, Tom Burke, Eugenia Jones, Leonard Kaczmarek, Kile P. Mangan 2697-Pos Board B304 K CA 3.1 AS MASTER REGULATOR IN INFLAMMATORY OSTEOCLASTOGEN- ESIS. Eva M. Grossinger , Mincheol Kang, Laura Bouchareychas, Ritu Sarin, Dominik Haudenschild, Laura Borodinsky, Iannis E. Adamopoulos 2698-Pos Board B305 OXIDATION OF K + CHANNELS IN TBI. Federico Sesti , Wei Yu, Randika Para- kramaweera, Janet Alder, Smita Thakker-Varia, Shavonne Teng 2699-Pos Board B306 PROTECTIVE ROLE OF OLESOXIME IN ALPHA-SYNUCLEIN-INDUCED MITO- CHONDRIAL DYSFUNCTION. Amandine Mf Rovini 2700-Pos Board B307 RIP3 MEDIATES NECROPTOTIC CELL DEATH IN RESPONSE TO ACID STIMU- LATION OF ASIC1A. Yu Huang , Qin Hu, Jun-Long Huang, Jaepyo Jeon, Tian-Le Xu, Michael Xi Zhu 2701-Pos Board B308 THE FUNCTION AND MECHANISM OF TMEM16A/ANO1 IN PANCREATIC CANCER. Yonjung Kim , Hyung Soon Park 2702-Pos Board B309 THE ROLE OF BK CHANNEL IN MICROGLIA ACTIVATION. Xiaoying Yang, Wenying Zhao, Li Zhang, Jianmin Cui, Xiaohui Sun , Xuechu Zhen 2703-Pos Board B310 KV1.3 INHIBITION REDUCES AMYLOID-BETA INDUCED MICROGLIAL NEUROTOXICITY. Heike Wulff , Jacopo Di Lucente, Hai M. Nguyen, Vikrant Singh, Lee-Way Jin, Izumi Maezawa Other Channels II (Boards B311–B326) 2704-Pos Board B311 LYSENIN GATING IMPLIES STRONG INTERACTION BETWEEN THE VOLT- AGE-GATING SENSOR AND THE BILAYER MEMBRANE: AN IONIC SCREEN- ING STUDY. Samuel R. Kosydar , Kaitlyn S. Ware, Sheenah Bryant, Nisha Shrestha, Charles Hanna, Daniel Fologea 2705-Pos Board B312 SUBUNITS THAT FORM TRIMERIC DEG/ENAC MECHANO-ELECTRICAL TRANSDUCTION CHANNELS IN TOUCH RECEPTOR NEURONS. Sylvia Fechner , Frederic Loizeau, Adam L. Nekimken, Beth L. Pruitt, Miriam B. Board B313 TRACKING PORE HYDRATION WITHIN THE RED-ACTIVATABLE CHAN- NELRHODOPSIN REACHR BY SITE-DIRECTED LABELING WITH INFRARED- ACTIVE AZIDO PROBES. Benjamin S. Krause , Joel C. D. Kaufmann, Jens Kuhne, Johannes Vierock, Thomas Huber, Thomas P. Sakmar, Klaus Gerwert, Franz J. Bartl, Peter Hegemann 2707-Pos Board B314 MECHANISM OF WATER AND SOLUTE COTRANSPORT BY THE SODIUM GLUCOSE COTRANSPORTER SGLT1. Christine Siligan , Andreas Horner, Sergey Akimov, Peter Pohl 2708-Pos Board B315 CHIMERIC INNEXINS REVEAL COMPLEXITIES OF ELECTRICAL RECTIFICA- TION.  Jamal B. Williams , Martha Skerrett 2709-Pos Board B316 FIGURING OUT FLUORIDE TRANSPORT. Benjamin McIlwain , Randy Stockbridge Goodman 2706-Pos

2683-Pos Board B290 ION TRANSPORT AND DEHYDRATION IN SUBNANOSCALE PORES. Subin Sahu , Massimiliano Di Ventra, Michael Zwolak 2684-Pos Board B291 MOLECULAR DETERMINANTS OF STRUCTURAL COUPLING BETWEEN C- TYPE INACTIVATION AND INNER GATE OPENING IN K + CHANNELS.  Jing Li , Jared Ostmeyer, Eduardo Perozo, Benoit Roux 2685-Pos Board B292 INVESTIGATION OF IONIC COULOMB BLOCKADE IN SUB-1 NM NANO- PORES WITH MOLECULAR DYNAMICS SIMULATIONS. Zhongwu Li , Kun Li, Pinyao He, Haojie Yang, Anping Ji, Yunfei Chen 2686-Pos Board B293 GLUTAMATE RECEPTOR ION CHANNEL ACTIVATION MECHANISM RE- VEALED BY CRYO-EMMAPS. Xiongwu Wu , Bernard R. Brooks 2687-Pos Board B294 THE C-TERMINAL DOMAIN OF KV1.3 INTERACTS WITH KCNE4 TO FORM OLIGOMERIC CHANNELS. Sara R. Roig , Laura Solé, Albert Vallejo-Gracia, Daniel Sastre, Antonio Serrano-Albarrás, Clara Serrano-Novillo, Ramón Martínez-Mármol, Michael M. Tamkun, Antonio Felipe 2688-Pos Board B295 STRUCTURAL AND FUNCTIONAL RESPONSE OF A MECHANOSENSITIVE K2P K + CHANNEL TO ASYMMETRIC MEMBRANE TENSION. Viwan Jarerattanachat , Michael V. Clausen, Prafulla Aryal, Elisabeth P. Carpenter, Mark S.P. Sansom, Stephen J. Tucker 2689-Pos Board B296 FLUCTUATION-DRIVEN TRANSPORT IN BACTERIAL CHANNELS UNDER ACIDIC STRESS. María L. López, María Queralt-Martín, Vicente M. Agu- ilella, Antonio Alcaraz Ion Channels, Pharmacology, and Disease II (Boards B297–B310) 2690-Pos Board B297 SODIUM VALPROATE REVERSES ELECTRICAL REMODELING OF ATRIAL MYOCYTES ISOLATED FROM CREM-IBΔC-X TRANSGENIC MICE.  C. Florentina Pluteanu , Beatrix Scholz, Jan S. Schulte, Frank U. Müller 2691-Pos Board B298 HEART FAILURE IS ASSOCIATED WITH ACTIVATION OF THE UNFOLDED PROTEIN RESPONSE AND ELECTRICAL REMODELING THAT IS PARTIALLY REVERSED BY A PERK INHIBITOR. Man Liu , Guangbin Shi, Hong Liu, Samuel C. Dudley 2692-Pos Board B299 A DE NOVO LOSS-OF-FUNCTION MUTATION IN KCNJ6 ASSOCIATED WITH IDIOPATHIC VENTRICULAR TACHYCARDIA. Franck Potet , Ruth McGowan, Karen McLeod, Alfred L Jr. George 2693-Pos Board B300 International Travel Awardee RESTORING DEFECTIVE CAMP-DEPENDENT UPREGULATION IN LONG-QT SYNDROME TYPE-1 THROUGH INTERVENTIONS THAT PROMOTE I KS CHAN- NEL OPENING. Cristina Moreno Vadillo , Roel L.H.M.G. Spätjens, Sandrine Seyen, Gabriele Menini, Jordi Heijman, Paul Volders 2694-Pos Board B301 KCA1.1 CHANNEL AUXILIARY BETA SUBUNIT COMPOSITION IN GLIO- BLASTOMA MULTIFORME. Zoltan Denes Petho , Andras Balajthy, Almos Klekner, Laszlo Bognar, Zoltan Varga, Gyorgy Panyi 2695-Pos Board B302 THE UREMIC TOXIN P-CRESOL REDUCES CELL SURFACE EXPRESSION OF HUMAN ETHER-A-GO GO-RELATED GENE (HERG) CHANNELS VIA THE UBIQUITIN LIGASE NEDD4-2. Ellen G. Avery , Shawn Lamothe, Shetuan Zhang, Jun Guo, Wentao Li, Tonghua Yang

W E

D N

E S

D A Y

145