Biophysical Society 61st Annual Meeting | Program Guide

2749-Pos Board B356 ABNORMAL CARDIAC CROSS-BRIDGE KINETICS IN A TROPONIN T IL- E79ASN TRANSGENIC MOUSE MODEL. David Gonzalez-Martinez, Karissa D. Jones, Maicon Landim-Vieira, Kwangjun Lee, Yeojung Koh, Bjorn C. Knollmann, P. Bryant Chase, Hyun S. Hwang, Jose R. Pinto 2750-Pos Board B357 A NOVEL DCM-ASSOCIATED MUTATION IN THE N-HELIX OF CARDIAC TROPONIN C EXHIBITS IMPAIRED CONTRACTILE KINETICS AND REDUCED CA 2+ -SENSITIVITY IN VITRO .  Jamie Johnston , David Gonzalez-Martinez, Einat Birk, Nili Zucker, Maicon Landim-Vieira, P. Bryant Chase, Yael Wilnai, Jose R. Pinto 2751-Pos Board B358 THIN FILAMENT-MEDIATED MODULATION OF MOUSE CARDIAC CROSS- BRIDGE KINETICS BY CA 2+ -SENSITIZING MUTATION CTNC-A8V OR BEPRI- DIL. David Gonzalez-Martinez , Maicon Landim-Vieira, Jamie Johnston, Weikang Ma, Brittany Griffin, Olga Antipova, Omar Awan, P. Bryant Chase, Thomas Irving, Jose R. Pinto 2752-Pos Board B359 THE ACTC A295S HYPERTROPHIC CARDIOMYOPATHY MUTATION PRO- MOTES THIN FILAMENT DISINHIBITION AND ENHANCES CONTRACTILE ACTIVITY. Meera C. Viswanathan, William Schmidt, Marek Orzechowski, William Lehman, Anthony Cammarato 2753-Pos Board B360 CPOW Travel Awardee CARDIAC-SPECIFIC EXPRESSION OF VCP/TER94 RNAI OR DISEASE ALLELES DISRUPTS DROSOPHILA HEART STRUCTURE AND IMPAIRS FUNCTION. Anna C. Blice-Baum , Meera C. Viswanathan, Tzu-Kang Sang, Anthony Cammarato Actin Structure, Dynamics, and Associated Proteins (Boards B361–B375) 2754-Pos Board B361 COMPARING THE EFFECTS AND REGULATIONS OF COFILIN ON ACTIN BARBED ENDS GENERATION IN LAMELLIPODIA VS. INVADOPODIA USING MATHEMATICAL MODELING. Nessy Tania , John Condeelis 2755-Pos Board B362 THE ROLE OF INTERMOLECULAR INTERACTIONS IN THE POLYMERIZATION OF ACTIN BY FORMINS. Fikret Aydin , Naomi Courtemanche, Thomas D. Pollard, Gregory A. Voth 2756-Pos Board B363 DISASSEMBLING THE CYTOSKELETON: EFFECTS OF ADF/COFILIN ON AC- TIN DYNAMICS. Hugo Wioland , Sarah Myram, Antoine Jégou, Guillaume Romet-Lemonne 2757-Pos Board B364 STRUCTURE OF THE ANTI-CANCER COMPOUND TR100 TARGET-SITES ON TPM3.1 TROPOMYOSIN. Michael Rynkiewicz , Justine Stehn, Peter Gun- ning, William Lehman 2758-Pos Board B365 MODULATING FORMIN PROCESSIVITY WITH MECHANICAL AND BIO- CHEMICAL FACTORS. Guillaume Romet-Lemonne 2759-Pos Board B366 A MODEL SYSTEM FOR THE RECONSTITUTION OF THE CELLULAR ACTIN CORTEX. Or Gill , Anne Bernheim-Groswasser 2760-Pos Board B367 THE MECHANOSENSITIVITY OF ACTIN BUNDLES. Emiko Suzuki

2738-Pos Board B345 STRUCTURE-BASED DISCOVERY OF NOVEL GLYCINERGIC MODULA- TORS. Marta M. Wells , Nathan Reinert, Pei Tang, Yan Xu Cardiac Muscle Mechanics and Structure II (Boards B346–B360) 2739-Pos Board B346 ATRIAL REMODELING IN HYPERTROPHIC CARDIOMYOPATHY. Cecilia Ferrantini , Josè Manuel Pioner, Francesca Gentile, Raffaele Coppini, Cristina Morelli, Nicoletta Piroddi, Beatrice Scellini, Elisabetta Cerbai, Jil Tardiff, Chiara Tesi, Iacopo Olivotto, Corrado Poggesi 2740-Pos Board B347 MYOSIN ACTIVATOR OMECAMTIV MECARBIL DIFFERENTIALLY IMPACTS THE CONTRACTILE PROPERTIES OF SKINNED MYOCARDIUM FROM FAILING AND DONOR HUMAN HEARTS. Ranganath Mamidi , Kenneth S. Gresham, Jiayang Li, Julian E. Stelzer 2741-Pos Board B348 BIOCHEMICAL AND MECHANICAL PROPERTIES OF THE S532P AND R712L CARDIOMYOPATHY MYOSIN MUTANTS. Ailian Xiong , Yingying Liu, Bipasha Barua, Betty Belknap, Howard White, Donald Winklemann, Eva Forgacs 2742-Pos Board B349 PEPTIDES DESIGNED TO DESTABILIZE THE MYOSIN COILED COIL ENHANCE MYOFIBRIL SHORTENING WHILEPEPTIDES THAT STABILIZE THE COILED COIL INHIBIT MYOFIBRIL SHORTENING. Rohit Singh, Motamed Qedan, Negar Aboonasrshiraz, Dua’a Quedan, Daniel Wang, Douglas D. Root 2743-Pos Board B350 REDUCED BINDING OF THE M-DOMAIN OF CARDIAC MYOSIN BINDING PROTEIN C TO ACTIN IMPAIRS THE ABILITY OF THE HEART TO RESPOND TO CHRONIC STRESS. Sabine J. van Dijk , Joshua Strom, Samantha P. Harris 2744-Pos Board B351 STRUCTURAL DYNAMICS OF HUMAN CARDIAC MYOSIN-BINDING PRO- TEIN C REVEALED BY TIME-RESOLVED FRET. Thomas A. Bunch, Victoria C. Lepak, Brett A. Colson 2745-Pos Board B352 INCREASED PHOSPHORYLATION OF CARDIAC MYOSIN BINDING PROTEIN C AND INCREASED EXPRESSION OF TROPONIN I IN NORMAL HUMAN AGEING. Lisa Nguyen, James McNamara, Cris Dos Remedios , Amy Li, Sean Lal 2746-Pos Board B353 PSEUDO-PHOSPHORYLATION MEDIATED RESCUE OF R58Q-LINKED FAMILIAL HYPERTROPHIC CARDIOMYOPATHY PHENOTYPE. Sunil Yadav , Katarzyna Kazmierczak, Jingsheng Liang, Danuta Szczesna-Cordary 2747-Pos Board B354 MOLECULAR MECHANISMS INVOLVED IN CARDIOSKELETAL DYSFUNC- TION CAUSED BY MUTATIONS IN MYOSIN RLC LINKED TO HYPERTROPHIC CARDIOMYOPATHY. Danuta Szczesna-Cordary , Chen-Ching Yuan, Katar- zyna Kazmierczak, Zhiqun Zhou, Jingsheng Liang, Sunil Yadav, Thomas C. Irving, Jenice X. Cheah, Aldrin V. Gomes 2748-Pos Board B355 Education Travel Awardee DISTINCT LATTICE STRUCTURE ALTREATIONS IN DCM AND HCMMOUSE MODELS ASSOCIATED WITH MUTATIONS IN MYOSIN REGULATORY LIGHT CHAIN. Chen-Ching Yuan , Jingsheng Liang, Katarzyna Kazmierczak, Zhiqun Zhou, Rosemeire Kanashiro-Takeuchi, Thomas C. Irving, Danuta Szczesna- Cordary

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