Biophysical Society 61st Annual Meeting | Program Guide

Career Center Workshop Looking Beyond Academia: Identifying Your Career Options Using MyIDP, LinkedIn, and More 10:30 am - 11:30 am, Room 212/213 Not sure where your professional future lies or how to approach the process in an organized and strategic manner? This presentation provides a framework and resources for moving forward with confidence towards the next step in your professional future. In addition, it will provide specific examples of how to build out your knowledge of a new potential career field and forge valuable connections that can facilitate a successful transition. Exhibitor Presentation Carl Zeiss Microscopy LLC 10:30 am - 12:00 pm, Room 221 ZEISS Live Cell Imaging Tools Allow New Levels of Throughput and Image Quality Imaging live cell samples offers unique insights into cellular function and gives the freedom to explore dynamic changes in cell behavior. Successful live cell imaging relies on maintenance of an appropriate cellular environment and an effort to minimize cellular damage. Keep- ing up with dynamic events inside a cell requires an optical design that produces gentle high signal to noise images. The optical design and configuration of the imaging platform plays a crucial role in the success of an imaging experiment. ZEISS has introduced a completely automated inverted platform, the Celldiscoverer 7, which simplifies every aspect of experimental setup and gives every live cell experiment the best chance for success. At the heart of the Celldiscoverer 7 is a completely unique optical concept with record setting optical resolution and light throughput. Paired with gentle LED illumination and image detectors designed for low magnification the Celldiscoverer 7 achieves new levels of imaging throughput. Complicated tasks of microscope configuration and op- timization are completely automated and designed to make the most of any sample type. Automated control of cellular environment allows imaging stability to be maintained over long time course experiments. The system can be expanded with a robotic plate loading system to al- low high throughput imaging from plate and slide based samples. The ZEISS LSM 880 confocal with Airyscan and FAST technology offers a unique optical design that counters the typical loss of sample light experienced when using a confocal pinhole. The Airyscan detector allows higher resolution and lower laser illumination while acquiring with higher SNR than typically possible. The result is superresolution imaging and the needed speed to follow live cells and record fast live cell events. Join this workshop and learn how the ZEISS Celldiscoverer 7 and the LSM 880 confocal with Airyscan FAST can help your imaging experi- ments in completely new ways. Speaker Scott Olenych, Academia Business Development Manager, Carl Zeiss Microscopy, LLC International Relations Committee Meeting 10:30 am - 12:00 pm, Room 204

Symposium New and Notable 10:45 am - 12:45 pm, Great Hall A

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Co-Chairs David W. Piston, Washington University and Catherine A. Royer, Rensellaer Polytechnic Institute No Abstract 10:45 am DNA LOOPING MEDIATES NUCLEOSOME TRANSFER.  Lucy Brennan No Abstract 11:05 am ATOMIC STRUCTURE OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR.  Jue Chen No Abstract 11:25 am CONNECTING ATOMISTIC TO CELLULAR SCALES IN COMPUTER SIMULATIONS OF A BACTERIAL CYTOPLASM. Michael Feig No Abstract 11:45 am SINGLE MOLECULE INSIGHTS INTO THE ASSEMBLY AND CATALYTIC ACTIVATION OF SPLICEOSOMES.  Aaron Hoskins No Abstract 12:05 pm RESOLVING THE STRUCTURAL MECHANICS OF NUCLEAR INTERMEDIATE FILAMENTS IN SITU USING A CORRELATIVE AFM AND CRYO-EM APPROACH.  Tanuj Sapra No Abstract 12:25 pm A NEWLY-IDENTIFIED INTERACTION MOTIF ASSOCIATED WITH GATING IN VOLTAGE-GATED SODIUM CHANNELS.  Bonnie Wallace Symposium RNA Structures and Dynamics 10:45 am - 12:45 pm, Great Hall B Chair Sarah Woodson, Johns Hopkins University 135-Symp 10:45 am CLEAVING FAST AND SLOW: STRATEGIES FOR SELF-ASSEMBLY OF CATALYTIC RNA.  Sarah A. Woodson , Subrata Panja, Boyang Hua, Krishnarjun Sarkar, Taekjip Ha No Abstract 11:15 am RNA TERTIARY STRUCTURE AND THE REGULATION OF GENE EXPRESSION. 11:45 am ADVENTURES WITH RNA GRAPHS.  Tamar Schlick 137-Symp 12:15 pm THE STRUCTURAL AND MECHANISTIC ORIGINS OF CATALYSIS IN NUCLEOLYTIC RIBOZYMES.  David M. Lilley , Timothy J. Wilson, Yijin Liu Platform Membrane Receptors and Signal Transduction I 10:45 am - 12:45 pm, Room R02/03 Co-Chairs Sarah A. Shelby, Cornell University Davide Provasi, Mount Sinai School of Medicine 138-Plat 10:45 am OLIGOMERIZATION OF THE EPIDERMAL GROWTH FACTOR RECEPTOR ORGANIZES KINASE-ACTIVE DIMERS INTO COMPETENT SIGNALING PLATFORMS.  Sarah R. Needham , Laura C. Zanetti-Domigues, Anton Arkhipov, Venkatesh P. Mysore, Dimitrios Korovesis, Selene K. Roberts, Christopher J. Tynan, Daniel J. Rolfe, Michael Hirsch, Alireza Lajevardipour, Andrew H.A Clayton, Peter J. Parker, Yibing Shan, David E. Shaw, Marisa L. Martin-Fernandez Anna Pyle 136-Symp

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