Biophysical Society 61st Annual Meeting | Program Guide

Exhibitor Presentations Rooms 218, 221, Ernest N. Morial Convention Center

Room 218: Monday, February 13

1:30 pm–3:00 pm Malvern Instruments Molecular Interactions of Proteins & Small Molecules Factors describing the stability of any protein formulating can generally be classified into two areas, conformational stability and colloidal stabil- ity. Conformational stability relates to the intrinsic properties of a protein molecule and can be described by a range of parameters such as melting point, enthalpy, aggregation onset temperature, and composition of aggregate. These parameters can be observed using many traditional techniques such as Differential Scanning Calorimetry (DSC), Dynamic Light Scattering (DLS), and Size Exclusion Chromatography (SEC).   Colloidal stability in contrast, is a property that describes extrinsic behav- ior of proteins in a bulk solution, and can be a key attribute in ensuring product quality. The most commonly observed properties to quantify colloidal stability include the diffusion interaction parameter (kD), second virial coefficient (B22), zeta potential (ζ), viscosity (η) and hydrodynamic size (rh). The workshop will introduce a newly developed technique called Taylor Dispersion Analysis (TDA), which provides an automated method for anal- ysis of hydrodynamic size and kD using small volumes of sample (<5uL) without the need for serial dilutions. This presentation will compare and contrast the results of Taylor Dispersion Analysis to that of traditional analysis methods to further understand the complimentary nature of these results. Speaker Matthew McGann, Product Manager, Innovation Products, Malvern Instruments 3:30 pm–5:00 pm OriginLab Corporation Origin 2017 Product Demo This workshop will focus on graphing and analysis using our latest version, Origin 2017. The following topics will be covered: Importing ASCII, Excel and third- party files. Creating and customizing 2D, 3D and specialized graphs. Using graph templates and themes for repeat plotting. Batch plotting. Exporting and publishing. Data processing. Data exploration. Linear and nonlinear regression. Peak analysis. Statistics. Batch analysis and custom reports using templates. Installing Apps from the OriginLab website. Speaker Chris Drozdowski, Technical Support, OriginLab Corporation

11:30 am–1:00 pm Asylum Research, an Oxford Instruments Company Now Playing: Video-Rate AFM with the New Cypher VRS Atomic Force Microscope Join our free lunch and learn as we introduce the first and only full-fea- tured, video-rate AFM for imaging biological processes— the Cypher VRS Atomic Force Microscope. The Cypher VRS enables high resolution video- rate imaging at 625 lines per second with incredibly easy operation and modularity to support other modes and environmental accessories. The Cypher VRS is capable of imaging samples at 10 frames per second with unprecedented resolution for clearly observing dynamics such as the action of restriction enzymes digesting DNA molecules. Perfusion can also be performed during experiments to observe growth crystal in real time and molecular arrangements of self-assembled monolayers (SAMs).  All the ease-of-use features of the industry-leading Cypher ES AFM increase productivity such as automated laser positioning, cantilever calibration, and blueDriveTM photothermal excitation for stable imaging and quan- titative measurements. No other AFM can match the combined perfor- mance of video-rate speed, high resolution and versatility. Learn all the details about Cypher VRS and be entered in our iPad drawing (must be present to win). See it in action in Booth 608. Speaker Iréne Revenko, Product Manager, Asylum Research, an Oxford Instruments Company

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