Biophysical Society 61st Annual Meeting | Program Guide

12:30 pm–2:00 pm Nanion Technologies GmbH Ion Channel Drug Discovery - Beyond the Bottlenecks and Ready for CiPA Nanion Technologies is one of the leading providers of automated patch clamp systems, offering a diverse product portfolio for experiments rang- ing from single channel recordings to HTS-compatible ion channel drug discovery. During this workshop, we will demonstrate how to push the boundaries of patch clamp-based ion channel high throughput screening projects of various voltage- and ligand gated targets, and how to get ready for CiPA-compliant safety screening beyond hERG. The CIPA initiative is an ongoing validation program aimed at improv- ing the regulatory requirements for proarrhythmia risk assessment. In accordance with the CiPA-initiative, the panel of cardiac ion channels to consider will drastically expand, consequently requiring increased data throughput for early compound safety prediction. The SyncroPatch 384/768PE, an automated patch clamp platform record- ing from up to 768 cells simultaneously, allows the highest data through- put on the market supporting HTS of ion channel active compounds and early safety assessment on cardiac channels. Data of six different cardiac channels recorded in the voltage clamp mode, using one single plate, will be shown. The SyncroPatch 384/768PE also supports automated current clamp recordings, experiments at physiological temperature, and minimal cell usage, making it the ideal partner for safety testing on stem cell- derived cardiomyocytes. The CardioExcyte 96 is a hybrid system combining impedance and EFP recordings from beating cardiomyocyte networks from 96 wells in paral- lel. The CardioExcyte 96 has proven a versatile tool for safety and toxicity screening applications serving as a powerful tool complementing APC. Join our workshop to learn more about new safety screening strategies and how to keep up with the increasing demands on cardiac safety and toxicity screening. Space is limited so reserve yours by sending an email to info@nanion.de. Speakers Andrea Brüggemann, CSO, Nanion Technologies GmbH Niels Fertig, CEO, Nanion Technologies GmbH Markus Rapedius, Senior Scientist, Nanion Technologies GmbH

2:30 pm–4:00 pm HORIBA Scientific Experience the New Shape and SPEED of Things to Come in Fluorescence HORIBA Scientific is proud to introduce a revolutionary new fluorescence/ UV-Vis spectrometer that advances beyond larger, slower, multi-step scanning fluorometers. The design consists of a harmonious blend of two spectroscopies, Fluorescence AND Absorbance, applied in a unique and patented way. The system combines a patented two-in-one fluorescence / UV-Vis spectrometer with an ultrafast CCD that acquires fluorescence spectra in the blink of an eye. It features a smaller, more elegant and ergonomic design than current fluorometers with a simple and unique interchange- able sampling arrangement. In addition to traditional fluorescence AND UV-Vis-NIR absorbance spectroscopy modalities, the new system features ultra-fast fluorescence Excitation EmissionMatrices (EEMs), simultaneous absorbance allowing for extended linear dynamic range due to automatic inner filter effect corrections, and unique molecular fingerprinting capa- bilities not available on any other commercial fluorometer. The new instrument has a standard wavelength range from 200 to 1,100 nm and a scan speed of over 5,000,000 nm/min, allowing the system to go further into the NIR, and acquire data much faster than any competi- tive mid-market, bench-top spectrofluorometer. Beyond even all of these unique benefits, this new instrument is also much more sensitive than any other commercial bench-top spectrofluo- rometer. Just as the hardware and configuration are all new, so too is the software that runs the instrument. Running on the latest touch screen Windows operating systems, this newest generation of spectroscopy software offers dedicated apps-driven icons that simplify the user experience and the operation of the instrument. Researchers and students will easily be able to perform fluorescence, absorption or simultaneous fluorescence and absorbance measurements and applications without prior software training. Come see a presentation and demonstration of this exciting new instru- ment from the leaders in fluorescence! Speaker Cary Davies, Global Product Line Manager, Fluorescence Division, HORIBA Scientific

162