Biophysical Society 61st Annual Meeting | Program Guide

Platform Protein Dynamics and Allostery I 10:45 am - 12:45 pm, Room R08/09

172-Plat 11:30 am PARTITIONING OF Γ-SECRETASE AND ITS SUBSTRATES IN LIPID MICRODO- MAINS. Marilia Barros , William Houlihan, Lane Gilchrist, Yueming Li 173-Plat 11:45 am LIPID/POLYDIACETYLENE VESICLE COMPOSITION ALTERS MUTANT BETA-AMYLOID PEPTIDE INTERACTION.  Elizabeth A. Yates , Michael P. Dorsey, Brice M. Nguelifack 174-Plat 12:00 pm SYNAPTOTAGMIN INTERACTIONS WITH MEMBRANES: MEASURING THE FORCE OF CALCIUM TRIGGERING OF NEUROTRANSMISSION.  Clemence Gruget , Jeff Coleman, Shyam Krishankumar, James E. Rothman, Frédéric Pincet, Stephen Donaldson 175-Plat 12:15 pm STUDY OF INSERTION OF DENGUE E INTO LIPID BILAYERS BY NEUTRON REFLECTIVITY AND MOLECULAR DYNAMICS SIMULATIONS.  Juan M. Vanegas, Frank Heinrich, David M. Rogers, Bryan D. Carson, Sadie La Bauve, Brianna C. Vernon, Bulent Akgun, Sushil Satija, Aihua Zheng, Mar- garet Kielian 10 , Susan B. Rempe, Michael S. Kent 176-Plat 12:30 pm THE GREAT NUCLEAR ESCAPE: STRUCTURE-BASED MECHANISM OF MEMBRANE BUDDING DURING NUCLEAR EGRESS OF HERPESVIRUS- ES.  Ekaterina E. Heldwein , Janna M. Bigalke Platform Cardiac, Smooth, and Skeletal Muscle Electrophysiology 10:45 am - 12:45 pm, Room 208/209 Co-Chairs Guiling Zhao, University of Maryland School of Medicine Bernard Attali, Tel Aviv University, Israel 177-Plat 10:45 am ACTION POTENTIAL HETEROGENEITY IN MURINE SINOATRIAL NODE MYOCYTES.  Christian Rickert , Catherine Proenza 178-Plat 11:00 am SK4 CA 2+ -ACTIVATED K + CHANNELS REGULATE SINOATRIAL NODE FIRING RATE AND CARDIAC PACING IN VIVO .  Bernard Attali , David Weisbrod, Hanna Bueno, Joachim Behar, Shiraz Haron-Khun, Dor Yadin, Asher Peretz, Michael Arad, Yael Yaniv 179-Plat 11:15 am CHARACTERISTICS OF IVABRADINE-SENSITIVE CURRENTS IN MOUSE SINOATRIAL NODE MYOCYTES.  Emily J. Sharpe , Stephanie C. Gantz, Pin Liu, Bruce P. Bean, Catherine Proenza 180-Plat 11:30 am CALCIUM ACTIVATED CHLORIDE CURRENT IN MAMMALIAN VENTRICU- LAR MYOCYTES.  Janos Magyar , Balázs Horváth, Krisztina Váczi, Bence Hegyi, Mónika Gönczi, Beatrix Dienes, Kornél Kistamás, Tamás Bányász, István Baczkó, András Varró, György Seprényi, László Csernoch, Péter P. Nánási, Norbert Szentandrássy 181-Plat 11:45 am PROPERTIES OF NEW VOLTAGE SENSITIVE DYES IN CARDIAC FIELD.  Ndeye Rokhaya Faye , Sushmitha RAJA, Richard Walton, Phillipe Pasdois, Fabien Brette, Alan Urban, Alexandre Hentz, Gihad Dargazanli, Olivier Bernus 182-Plat 12:00 pm DYNAMIC BLOOD FLOW CONTROL IN HEART.  Guiling Zhao , Humberto Joca, W. Jonathan Lederer

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Co-Chairs Magnus Wolf-Watz, Universitry of Umeå, Sweden Sonya M. Hanson, Memorial Sloan Kettering Cancer Center 161-Plat 10:45 am

MOLECULAR SIMULATIONS TO UNRAVEL THE ALLOSTERIC INTERPLAY BE- TWEEN THE SH2 DOMAIN AND A-LOOP PLASTICITY IN PROTEIN KINASES.  Giuseppina La Sala , Laura Riccardi, Roberto Gaspari, Andrea Cavalli, Oliver Hantschel, Matteo Dal Peraro, Marco De Vivo 162-Plat 11:00 am SUBUNIT EXCHANGE AND ACTIVATION OF HUMAN CAMKII VARIANTS.  Ana P. Torres OCampo, Brendan Page, Margaret Stratton 163-Plat 11:15 am CAN WE AUTOMATICALLY DETECT BIOLOGICALLY RELEVANT ORDER PA- RAMETERS IN MOLECULAR SIMULATION? COMPARING LONG TIMESCALE SIMULATIONS OF MULTIPLE KINASES.  Sonya M. Hanson , Joshua H. Fass, John D. Chodera 164-Plat 11:30 am EVOLUTION OF REGULATORY DIVERSITY IN THE KINASE SUPERFAMILY.  Jai Pandey, Orna Resnekov, David Pincus, Kimberly A. Reynolds 165-Plat 11:45 am THE G41S VARIANT OF HUMAN CYTOCHROME C ENHANCES APOPTOSIS VIA INCREASED DYNAMICS.  Andreas Ioannis Karsisiotis, Oliver M. Deacon, Michael T. Wilson, Colin Macdonald, Tharin M. A. Blumenschein , Geoffrey R. Moore, Jonathan A. R. Worrall 166-Plat 12:00 pm GLOBAL DISORDERING IN STEREO-SPECIFIC PROTEIN ASSOCIATION.  Arun Gupta, Ines Reinartz, Alessandro Spilotros, Venkateswara R. Jonna, Anders Hofer, Dmitri I. Svergun, Alexander Schug, Magnus Wolf-Watz 167-Plat 12:15 pm ROLE OF CONFORMATIONAL ENTROPY IN EXTREMELY HIGH AFFINITY PROTEIN INTERACTIONS.  Jose A. Caro 168-Plat 12:30 pm PRESSURE EFFECTS ON DISSOCIATION OF CHEY-FLIM COMPLEX STUDIED BY MOLECULAR DYNAMICS SIMULATIONS.  Hiroaki Hata , Yasutaka Nishi- hara, Masayoshi Nishiyama, Ikuro Kawagishi, Akio Kitao Platform General Protein-Lipid Interactions I 10:45 am - 12:45 pm, Room 206/207 Co-Chairs Katya Heldwein, Tufts University School of Medicine Edward R. Lyman, University of Delaware 169-Plat 10:45 am PREDICTING CHOLESTEROL INTERACTION SITES ON GPCRS BY MOLECU- LAR SIMULATION.  Edward R. Lyman , Clement Arnarez, Eric Rouviere 170-Plat 11:00 am MEMBRANE CHOLESTEROL AND THE ADENOSINE A 2A RECEPTOR.  Claire McGraw , Anne S. Robinson 171-Plat 11:15 am PROBING CHOLESTEROL-DEPENDENCE OF INTEGRIN-UROKINASE RECEP- TOR COMPLEX FORMATION USING CONFOCAL DUAL-COLOR FLUORESCENCE INTENSITY ANALYSIS.  Yifan Ge, Jiayun Gao, Rainer Jordan, Christoph A. Naumann

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