Biophysical Society 61st Annual Meeting | Program Guide

Friday, February 10 Exhibitor Registration 8:00 am–5:00 pm, Lobby B Drug Discovery Satellite Meeting 8:00 am–5:00 pm, Room 210

11:00 AM OVERCOMING CHALLENGES OF TARGETING NAV1.9 FOR DEVELOPMENT OF NEW PAIN THERAPIES. Neil Castle 11:30 AM DISCOVERY OF NOVEL NAV1.7 SCAFFOLDS. Jun Chen 12:00 PM SELECTIVE INHIBITORS OF NAV1.7: FROM BINDING SITE TO IN-VIVO EF- FICACY. David Hackos 12:30 PM LUNCH (PROVIDED) SESSION III: ION CHANNELS AND DISEASE Chair, Richard Kondo 1:30 PM HIGH THROUGHPUT ELECTROPHYSIOLOGY TO ANNOTATE CHANNEL FUNCTIONS IN THE CONTEXT OF DISEASE GENETICS. Jen Pan 2:00 PM DRUG DISCOVERY FOR CANCER THERAPY: A COMBINATION OF HIGH THROUGHPUT ELECTROPHYSIOLOGY AND LIVE CELL AND CALCIUM IMAGING. Aamir Ahmed 2:30 PM GENERATING ION CHANNEL BLOCKING ANTIBODIES BY FUSING CYSTE- INE-KNOT MINIPROTEINS INTO ANTIBODY CDR LOOPS. John McCafferty 3:00 PM BREAK SESSION IV: REGULATION OF ION CHANNELS Chair, Jeff Webber 3:30 PM ALLOSTERIC MODULATORS OF CHANNEL-PIP2 INTERACTIONS . Diomedes Logothetis 4:00 PM ANTIDROMIC-RECTIFYING GAP JUNCTIONS AMPLIFY CHEMICAL TRANS- MISSION FROM PREMOTOR INTERNEURONS TO MOTONEURONS. Zhao-Wen Wang 4:30 PM TMEM16A: HIGH-THROUGHPUT FUNCTIONAL SCREENING APPROACHES TO A NOVEL THERAPEUTIC TARGET. Sarah Lilley 5:00 PM CLOSING REMARKS Niels Fertig New Council Orientation 3:00 pm - 4:30 pm, Hilton, Port Room Registration 3:00 pm–5:00 pm, Lobby B Joint Council Reception, Dinner, and Meeting 5:00 pm–9:00 pm, Hilton, Compass Room

F R I D A Y

Sponsored by Sophion together with Biolin Scientific, Charles River, Icagen Inc, Molecular Devices LLC, Nanion Technologies GmBH Ion channels are an important class of therapeutic drug targets, and mu- tations in ion channel genes are found to be responsible for an increasing number of diseases. While conventional electrophysiological techniques permit the most detailed and direct study of ion channel function, they are limited due to the manual nature of the method and their low throughput. Because of this, ion channels remain an underrepresented target class for drug discovery. But the advent of automated electro- physiological systems with higher throughput has begun to revolutionize ion channel drug discovery. This symposium focuses on the emerging technology of automated electrophysiology and how it is changing the face of ion channel drug discovery. Speakers from industry and academia will discuss the development and potential of these new technologies, present experimental results obtained using these systems and discuss the impact these technologies are having on ion channel drug discovery. Co-Chairs Richard Kondo, Sophion – Biolin Scientific Andrew Baxter, Charles River Chris Mathes, Icagen Inc Jeff Webber, Molecular Devices LLC Niels Fertig, Nanion Technologies GmbH 7:30 AM REGISTRATION 8:30 AM WELCOME AND OPENING REMARKS Chris Mathes 8:45 AM NEW INSIGHTS INTO K2P POTASSIUM CHANNEL BIOPHYSICS. Keynote Speaker: Stephen Tucker SESSION I: ANION CHANNELS Chair, Chris Mathes 9:30 AM STRATEGIES FOR DEVELOPING ISOFORM-SPECIFIC CLC CHLORIDE-CHAN- NEL INHIBITORS. Merritt Maduke 10:00 AM STRUCTURAL AND FUNCTIONAL STUDIES OF ANION CHANNELS. Tsung-Yu Chen 10:30 BREAK SESSION II: NA CHANNELS & PAIN Chair, Andrew Baxter

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