Biophysical Society 61st Annual Meeting | Program Guide

229-Plat 4:15 pm SPOTON: A MACHINE-LEARNING APPROACH FOR HOT-SPOT DETERMI- NATION.  Irina S. Moreira , Panos Koukos, Rita Melo, Jose G. Almeida, Antonio J. Preto, Jorg Schaarschmidt, Mikael Trellet, Zeynep H. Gumus, Joaquim Costa, Alexandre M.J.J. Bonvin 230-Plat 4:30 pm MORPHODYNAMIC PROFILING OF CELL PROTRUSION BASED ON SPATIOTEMPORAL SPECTRUM DECOMPOSITION AND UNSUPERVISED CLUSTERING.  Xiao Ma , Onur Dagliyan, Klaus Hahn, Gaudenz Danuser 231-Plat 4:45 pm MECHSTIFF : A NEW TOOL FOR EVALUATING STRESS-INDUCED DYNAMICS AND APPLICATION TO CELL ADHESION PROTEINS.  Karolina Mikulska-Ruminska , Andrzej J. Kulik, Cihan Kaya, Carine BenAdiba, Giovanni Dietler, Wieslaw Nowak, Ivet Bahar 232-Plat 5:00 pm OPTIMAL TEMPERATURE SET FOR REPLICA EXCHANGE SAMPLING.  Dominik Gront 233-Plat 5:15 pm MOLECULAR DESIGN OF A NANOPARTICLE-POLYMER CONJUGATED DRUG DELIVERY SYSTEM FOR PD-166793 IN CARDIOVASCULAR REPAIR.  Merina Jahan , Stephen K. Roberts, Andrew B. Greytak, Mark J. Uline 234-Plat 5:30 pm SYSTEMATIC ANALYSIS OF SYMMETRY IN MEMBRANE PROTEINS.  Antoniya A. Aleksandrova 235-Plat 5:45 pm MEMBRANE RECRUITMENT CAN INCREASE THE NUMBER OF PROTEIN ASSEMBLIES BY MANY FOLDS: INSIGHTS FROM THEORY AND REACTION- DIFFUSION SIMULATION.  Osman N. Yogurtcu , Margaret E. Johnson Exhibitor Presentation Oxford Nanoimaging Ltd 4:30 pm – 6:00 pm, Room 221 Meet the Nanoimager: The Next Generation of Super-Resolution Microscope Oxford Nanoimaging (ONI) have reinvented the single-molecule micro- scope to meet the needs of cutting edge research in the 21st century. The Nanoimager is a high-throughput, robust, single-molecule localisa- tion based microscope that does not go out of alignment. A compact dSTORM, PALM and single-molecule FRET solution with a footprint small- er than an A4 piece of paper, the system offers the most stable platform on the market and can be run from a standard laboratory bench. High power 1W lasers and the most efficient light path of any commercial so- lution gives the Nanoimager excellent performance and sets a new stan- dard in super-resolution imaging. The Nanoimager is a small microscope with a big personality: expert capabilities and top performance for both novice and experienced users.  ONI have made single-molecule experi- ments easier, and have made instrument costs accessible to the majority. Come and learn more about the next generation of super-resolution microscopes: this presentation will not only introduce the newly released Nanoimager but will show the latest achievable data and the technical ability of this ground-breaking instrument. The Nanoimager needs to be seen to be believed. No alignment. No optical table. No compromise. Speaker Raphael Jorand, Applications Specialist, Oxford Nanoimaging Ltd

218-Plat 5:30 pm TUNING MEMBRANE ASYMMETRY: CONTROLLED UPTAKE OF NEGATIVELY CHARGED LIPIDS INTO THE OUTER LEAFLET OF LIPOSOMES. Marie Mar- kones, Carina Zorzin, Louma Kalie, Sebastian Fiedler , Heiko Heerklotz 219-Plat 5:45 pm INVESTIGATING THE EFFECTS OF THE MEMBRANE DIPOLE FIELD ON THE STRUCTURE AND FUNCTION OF A MODEL MEMBRANE PROTEIN.  Cari M. Anderson , Lauren J. Webb Platform Kinesins and Dyneins 4:00 pm - 6:00 pm, Room 206/207 Co-Chairs Scott Forth, Rockefeller University Ryota Iino, Institute for Molecular Science, Japan 220-Plat 4:00 pm LIS1 HAS TWO DISTINCT MODES OF REGULATING DYNEIN’S MECHANO- CHEMICAL CYCLE. Michael A. Cianfrocco , Morgan E. DeSantis, ZawM. Htet, Phuoc T. Tran, Andres E. Leschziner, Samara L. Reck-Peterson 221-Plat 4:15 pm THE STRUCTURE OF COMPLETE HUMAN DYNEIN-1 AND ITS MECHANISM OF ACTIVATION.  Kai Zhang , Helen Foster, Andrew Carter 222-Plat 4:30 pm THE POWER STROKE DISTANCE OF HUMAN CYTOPLASMIC DYNEIN.  Yoshimi Kinoshita , Taketoshi Kambara, Kaori Nishikawa, Motoshi Kaya, Hideo Higuchi 223-Plat 4:45 pm Education Travel Awardee INTRACELLULAR CARGO TRANSPORT BY SINGLE-HEADED KINESIN MONOMERS.  Kristin I. Schimert , Breane G. Budaitis, Kristen J. Verhey 224-Plat 5:00 pm KINESIN-1 CARGO TRANSPORT THROUGH DENSE MICROTUBULE NETWORKS.  Joelle A. Labastide , Reilly K. Curtin, Jennifer L. Ross 225-Plat 5:15 pm AN ALLOSTERIC GEAR SHIFT MECHANISM IN EG5 ENHANCES MECHANOCHEMICAL COUPLING AND SHIFTS THE FORCE-VELOCITY LANDSCAPE.  Joseph Muretta , Babu J N Reddy, Guido Scarabelli, David D. Thomas, Barry Grant, Steven Gross, Steven Rosenfeld 226-Plat 5:30 pm Education Travel Awardee SINGLE MOLECULE CHARACTERIZATION OF MITOTIC KIF15 REVEALS CAPABILITY TO GENERATE FORCE IN ANTI-PARALLEL MICROTUBULES.  Dana N. Reinemann , Emma G. Sturgill, Dibyendu Kumar Das, Ryoma Ohi, Matthew J. Lang 227-Plat 5:45 pm MEASURING FORCES GENERATED BY ENSEMBLES OF KINESIN-5 CROSSLINKING TWO MICROTUBULES.  Scott Forth , Yuta Shimamoto, Tarun Kapoor Platform Computational Methods and Bioinformatics 4:00 pm - 6:00 pm, Room 208/209 Co-Chairs Antoniya A. Aleksandrova, NINDS, NIH Aleksandra Karolak, University of South Florida 228-Plat 4:00 pm ELUCIDATING THE ROLE OF TUMOR MICROENVIRONMENTAL HETERO- GENEITY WITH A COMPUTATIONAL MODEL OF 3D BREAST SPHEROIDS.  Aleksandra Karolak , Branton Huffstutler, Dmitry A. Markov, Lisa J. Mc- Cawley, Katarzyna A. Rejniak

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