Biophysical Society 61st Annual Meeting | Program Guide

303-Pos Board B68 USING SINGLE MOLECULE FORCE SPECTROSCOPY TO DETECT HIGH-ENER- GY INTERMEDIATES ON PROTEIN FOLDING PATHWAY. Ha H. Truong , Emily J. Guinn, Susan Marqusee 304-Pos Board B69 FOLDING PATHWAYS OF EVOLUTIONARILY RELATED PROTEINS PROBED BY HYDROGEN EXCHANGE MASS SPECTROMETRY. Eric Bolin , Shion An, Susan Marqusee 305-Pos Board B70 HOW HYDRODYNAMIC INTERACTIONS AFFECT THE FOLDING RATE OF PROTEINS. Fabio C. Zegarra , Dirar Homouz, Margaret S. Cheung 306-Pos Board B71 FOLDING MECHANISMS OF SMALL PROTEINS GB1 AND LB1. Qianyi Cheng , Insuk Joung, Keehyoung Joo, Kunihiro Kuwajima, Jooyoung Lee 307-Pos Board B72 A NOVEL TRP CAGE CONFORMER REVEALED BY COMBINING HIGH PRES- SURE NMR AND MD SIMULATIONS. Martin J. Fossat , Soichiro Kitazawa, Scott McCallum, Angel Garcia, Catherine Royer 308-Pos Board B73 MICROFLUIDIC TURBULENT MIXERS, TIME RESOLVED SAXS AND FOLD- ING INTERMEDIATES OF CHEY. Sagar V. Kathuria , Osman Bilsel, Srinivas Chakravarthy, C. Robert Matthews 309-Pos Board B74 THERMAL AND CHEMICAL UNFOLDING OF CYTOCHROME C IN THE PRES- ENCE OF HOFMEISTER IONS. Eric S. Peterson , Collin A. O’Leary, Sean J. Steinke, Mikayla J. Freese 310-Pos Board B75 UNCOVERING CONFORMATIONAL SUBSTATES AND KINETIC CONSTANTS BY PRESSURE MODULATION. Roland Winter 311-Pos Board B76 INVESTIGATING COTRANSLATIONAL FOLDING IN MEMBRANE PROTEINS USING FRAGMENT-BASED STRUCTURE PREDICTION. Eleanor C. Law , Saulo H. P. de Oliveira, Sebastian Kelm, Jiye Shi, Charlotte M. Deane Protein Dynamics and Allostery I (Boards B77–B90) 312-Pos Board B77 MOLECULAR DYNAMICS SIMULATIONS FOR UNDERSTANDING IR SPEC- TRA AND THE DISTRIBUTION OF ENVIRONMENTS AROUND THE PHOS- PHOPANTETHEINE ARM OF ACYL CARRIER PROTEINS. Michael R. Jordan , Louise K. Charkoudian, Casey H. Londergan 313-Pos Board B78 CAUGHT IN THE ACT: TRAPPING AN ACYL CARRIER PROTEIN INTERACT- ING WITH A KETOSYNTHASE. Grace A. Thiele 314-Pos Board B79 ALLOSTERIC MODULATION OF A SERINE PROTEASE BY CONFORMATION- ALLY SELECTIVE NANOBODIES. Tobias Kromann-Hansen 315-Pos Board B80 ALLOSTERIC TRANSMISSION ALONG A LOOSELY STRUCTURED BACKBONE ALLOWS A CARDIAC TROPONIN C MUTANT TO FUNCTION WITH ONLY ONE CA 2+ ION. Mayra A. Marques , José R. Pinto, Adolfo H. Moraes, Anwar Iqbal, Mariana T. Q. de Magalhães, Jamila Monteiro, Murilo M. Pedrote, Martha M. Sorenson, Jerson L. Silva, Guilherme A. P. de Oliveira 316-Pos Board B81 DYNAMICS AND ASSEMBLY OF ASB-CONTAINING E3 UBIQUITIN LIGAS- ES. Ryan Lumpkin , Alla Ahmad, Melinda Chan, Elizabeth Komives

289-Pos Board B54 SELECTION MAINTAINING PROTEIN STABILITY AT EQUILIBRIUM. Sanzo Miyazawa 290-Pos Board B55 EFFECTS OF FLANKING DISORDER ON THE BEHAVIOUR OF ORDERED DOMAINS. Katie R. Kemplen , Petur O. Heidarsson, Lasse Staby, Charlotte O’Shea, Karen Skriver, Birthe B. Kragelund 291-Pos Board B56 THE EFFECT OF POLYDISPERSE CROWDING ON PROTEIN STABILITY. Alan van Giessen , Anastasia Osti 292-Pos Board B57 PAPS-SYNTHASE: DISSECTING FOLDING OF A LARGE AND NATURALLY FRAGILE PROTEIN IN VITRO AND IN CELLULO . Oliver Brylski , Jonathan Wolf Mueller, Simon Ebbinghaus 293-Pos Board B58 EFFECTS OF SALT OR COSOLVENT ADDITION ON THERMAL STABILITY OF A PROTEIN: RELEVANCE TO THOSE ON SOLUBILITY OF A HYDROPHO- BIC SOLUTE IN WATER. Shota Murakami, Tomohiko Hayashi , Masahiro Kinoshita 294-Pos Board B59 RESIDUAL STRUCTURE IN THE DENATURED STATE OF A THREE-HELIX BUNDLE PROTEIN. Dustin Becht , Klara Briknarova, Bruce Bowler 295-Pos Board B60 PHOSPHORYLATION INDUCED GLOBAL STRUCTURAL DESTABILIZATION OF A SMALL PROTEIN DOMAIN. Ashleigh Bachman , Radwan Ebna Noor, Dimitra Keramisanou, Ioannis Gelis 296-Pos Board B61 PROMISCUOUS CONTACTS AND HEIGHTENED DYNAMICS INCREASE THERMOSTABILITY IN AN ENGINEERED VARIANT OF THE ENGRAILED HOMEODOMAIN. Michelle E. McCully , Valerie Daggett 297-Pos Board B62 RATIONAL DESIGN OF A SYNTHETIC PEG-LIKE POLYMER FOR PROTEIN STABILIZATION. Christopher DelRe , Brian Panganiban, Tim Li, Charley Huang, Monica Olvera de la Cruz, Patrick Dennis, Ting Xu 298-Pos Board B63 STABILITY OF HSP60 FROM HELICOBACTER PYLORI: EFFECT OF GTP BIND- ING . Karina Guadalupe , Jose Mendoza  Folding Pathways (Boards B64–B76) 299-Pos Board B64 IN VITRO STUDIES OF THE FOLDING AND ASSEMBLY MECHANISM OF HEMOGLOBIN. Premila P. Samuel , William Ou, George N. Phillips, John Board B65 AN EVOLUTIONARY TREND TOWARDS KINETIC STABILITY IN THE FOLDING TRAJECTORY OF RNASES H. Shion An Lim , Kathryn M. Hart, Michael J. Harms, Susan Marqusee 301-Pos Board B66 INTERPRETING PHI-VALUES USING PROTEIN FOLDING TRANSITION PATHS. Robert Best , Gerhard Hummer 302-Pos Board B67 RECONSTRUCTING THE FOLDING OF LUCIFERASE TO ELUCIDATE THE VECTORIAL FOLDING PATHWAYS OF LARGE, MULTIDOMAIN PROTEINS.  Zackary N. Scholl , Weitao Yang, Piotr Marszalek S. Olson 300-Pos

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