Biophysical Society 61st Annual Meeting | Program Guide

360-Pos Board B125 IMPROVED SAMPLING IN MOLECULAR DYNAMICSSTUDIESOF DNA AND THE B TO Z[WC] TO Z-DNA TRANSITION. Lam T. Nguyen , Ashutosh Rai, Micaela E. Bush, Alma Gracic, Ahsan A. Khoja, Jinhee Kim, Sunil Pun, Alexander K. Seewald, Benjamin L. Yee, Michael G. Lerner 361-Pos Board B126 Education Travel Awardee ENERGETIC CONTRIBUTIONS OF PLECTONEME TIPS AND TAILS. Andrew Dittmore , Keir C. Neuman 362-Pos Board B127 MULTI-SCALE STRUCTURE AND CONFORMATIONAL DYNAMICS OF SCAF- FOLDED DNA ORIGAMI NANOPARTICLES. William Bricker , Keyao Pan, Mark Bathe  RNA Binding (Boards B128–B139) 363-Pos Board B128 SHEDDING LIGHT ON CAS9 TARGET SEARCH. Viktorija Globyte , Seung Hwan Lee, Luuk Loeff, Jin Soo Kim, Chirlmin Joo 364-Pos Board B129 TO CLEAVE OR NOT TO CLEAVE: PREDICTING THE TARGET SPECIFICITY OF CRISPR-CAS SYSTEMS THROUGH THEORETICAL MODELING. Misha Klein , Martin Depken 365-Pos Board B130 Education Travel Awardee CONFORMATIONAL DYNAMICS OF CAS9 DURING DNA BINDING. Yavuz S. Dagdas , Janice S. Chen, Samuel H. Sternberg, Jennifer A. Doudna, Ahmet Yildiz 366-Pos Board B131 REPETITIVE LOOP FORMATION BY THE CRISPR-CAS3 HELICASE. Luuk Loeff , Stan Brouns, Chirlmin Joo 367-Pos Board B132 THE IMPACT OF DNA TOPOLOGY ON TARGET SELECTION BY A CYTOSINE- SPECIFIC CAS9. Tsz Kin Martin Tsui , Travis H. Hand, Hong Li 368-Pos Board B133 CRISPR-CAS9: COMPUTATIONAL INSIGHTS TOWARD IMPROVED GENOME EDITING. Giulia Palermo , Yinglong Miao, Ross C. Walker, Martin Jinek, J. AndrewMcCammon 369-Pos Board B134 STRUCTURAL INSIGHTS INTO G-TRACT RECOGNITION BY THE HNRNP H RNA RECOGNITION MOTIF. Srinivasa R. Penumutchu 370-Pos Board B135 Education Travel Awardee BLIND PREDICTIONS OF RNA/PROTEIN RELATIVE BINDING AFFINI- TIES. Kalli Kappel , Inga Jarmoskaite, Pavan P. Vaidyanathan, William J. Greenleaf, Daniel Herschlag, Rhiju Das 371-Pos Board B136 CID Travel Awardee BIOPHYSICAL STUDIES OF LIPOSOME ENCAPSULATED POKEWEED ANTIVI- RAL PROTEIN AND ITS USE AS A HIV THERAPEUTIC. O’Jay Stewart , Artem Domashevskiy 372-Pos Board B137 A DEAD-BOX PROTEIN ACTS THROUGH RNA TO PROMOTE HIV-1 REV-RRE ASSEMBLY. Rajan Lamichhane , John A. Hammond, Raymond F. Pauszek, Ingemar Pedron, Edwin van der Schans, James R. Williamson, David P. Millar 373-Pos Board B138 DECIPHERING THE ACTION MECHANISM OF DDX3: AN RNA HELICASE IMPLICATED IN CANCER PROPAGATION AND PATHOGENIC VIRAL INFEC- TION. Anthony F. Moore , Aliana Lopez de Victoria, Eda Koculi

345-Pos Board B110 SIMULATING MOVEMENT OF THE RIBOSOME HEAD DURING TRANSLO- CATION. Karissa Y. Sanbonmatsu , Wataru Nishima  Nucleic Acid Structure and Dynamics I (Boards B111–B127) 346-Pos Board B111 EFFECTS OF 5-HYDROXYMETHYLCYTOSINE EPIGENETIC MODIFICATIONS WITHIN THE VEGF PROMOTER REGION ON G-QUADRUPLEX AND I-MOTIF DNA STRUCTURE AND STABILITY. Michael M. Molnar , Rhianna K. Mor- gan, Tracy A. Brooks, Randy M. Wadkins 347-Pos Board B112 TEMPERATURE DEPENDENCE OF L-PROLINE RNA DUPLEX DESTABILIZA- TION.  Jeffrey J. Schwinefus , Kalpit Modi, Nadia Baka 348-Pos Board B113 ENGINEERING DNA LOOPING IN E. COLI . Nicole A. Becker , Tanya L. Schwab, Karl J. Clark, L. James Maher III 349-Pos Board B114 INVESTIGATING THE STABILITY OF DNA DUPLEX HAIRPINS USING OPTICAL TWEEZERS. Leah Furman , Micah McCauley, Catherine A. Dietrich, Mark C. Williams, Megan E. Nunez 350-Pos Board B115 UNTWISTING OF DOUBLE-STRANDED DNA AND RNA INVESTIGATED BY MOLECULAR DYNAMICS SIMULATIONS. Korbinian Liebl 351-Pos Board B116 TRANSLOCATION OF STRUCTURALLY DEFINED BRANCHED DNA THROUGH NANOPORES. Philipp Karau , Kyle Briggs, Vincent Tabard-Cossa 352-Pos Board B117 THERMODYNAMIC LINKAGE ANALYSIS OF PH-INDUCED FOLDING AND UNFOLDING TRANSITIONS OF I-MOTIFS. Byul Kim , Tigran Chalikian 353-Pos Board B118 International Travel Awardee LIVE CELL IMAGING OF GENOMIC LOCI USING FLUORESCENT RNA AP- TAMERS. Adam Cawte , Sunny Jeng, Peter Unrau, David Rueda 354-Pos Board B119 ELUCIDATING THE ROLE OF TRANSCRIPTION IN SHAPING THE 3D STRUC- TURE OF THE BACTERIAL GENOME. Hugo Brandao , Xindan Wang, David Rudner, Leonid Mirny 355-Pos Board B120 INVESTIGATION OF THE MELTING THERMODYNAMICS OF A DNA 4-WAY JUNCTION: ONE BASE AT A TIME. Rachel E. Savage, Wujie Wang, Francis W. Starr, Ishita Mukerji 356-Pos Board B121 ROLE OF WATSON-CRICK-LIKE MISMATCHES IN DNA REPLICATION FIDEL- ITY. Eric S. Szymanski , Isaac J. Kimsey, HashimM. Al-Hashimi 357-Pos Board B122 International Travel Awardee DIRECT OBSERVATION OF SINGLE BIOPOLYMER FOLDING AND UNFOLD- ING PROCESS BY SOLID-STATE NANOPORE. Xin Shi , Rui Gao, Shao-Chuang Liu, Qiao Li, Yi-Tao Long 358-Pos Board B123 TUNING UP TETHERED PARTICLE MOTION. Daniel T. Kovari , Eric Weeks, David Dunlap, Laura Finzi 359-Pos Board B124 SMALL MOLECULE APTAMERS FOR BIOSENSING. Gregory Wiedman , Yunan Zhao, David Perlin

F R I D A Y

S U N D A Y

28