Biophysical Society 61st Annual Meeting | Program Guide

600-Pos Board B365 A NOVEL APPROACH TO IDENTIFY THE ROLE OF SINGLE MOLECULE TITIN MECHANICS IN HUMAN HEART FAILURE. Mei-pian Chen , Nancy S. Saad, Benjamin D. Canan, Ahmet Kilic, Peter J. Mohler, Paul M.L. Janssen 601-Pos Board B366 MODELING AND EXPERIMENT TO DETERMINE THE ROLE OF PASSIVE STIFFNESS ON MECHANICAL (STRAIN RATE) CONTROL OF RELAX- ATION. Charles S. Chung 602-Pos Board B367 DIRECT OBSERVATION OF STRAIN TRANSMISSION THROUGH THE MI- CROTUBULE NETWORK OF CARDIOMYOCYTES. Matthew A. Caporizzo , Brandon Kao, Patrick Robison, Alexey I. Bogush, Benjamin L. Prosser 603-Pos Board B368 NOVEL ROLES FOR OBSCURIN PROTEINS IN CARDIAC MUSCLE. Patrick F. Desmond , Stephanie Myers, Anush Velmurugan, Matthew Klos, Yusu Gu, Nancy Dalton, Eric Devaney, Kirk Peterson, Ju Chen, Stephan Lange 604-Pos Board B369 DIFFUSION IN THE TRANSVERSE-AXIAL TUBULE SYSTEM OF CARDIAC MYOCYTES. Cherrie Ht Kong , Eva A. Rog-Zielinska, Clive H. Orchard, Peter Kohl, Mark B. Cannell Cell Mechanics, Mechanosensing, and Motility I (Boards B370–B391) 605-Pos Board B370 FROM ELASTICITY TO INELASTICITY IN CANCER CELL MECHANICS: A LOSS OF SCALE INVARIANCE. Francoise Argoul 606-Pos Board B371 MIGRATION BEHAVIOR OF NORMAL AND METASTATIC HUMAN MAM- MARY CELLS.  Josiah Low , Keith Bonin, Hyunsu Lee, Amanda Smelser, Martin Guthold 607-Pos Board B372 ADHESION-CONTROLLED PROLIFERATION REVEALING ANTI-CANCER DRUG RESISTANCE OF BREAST CANCER CELLS. Soyeun Park 608-Pos Board B373 DIVISION INDUCED DYNAMICS IN NON-INVASIVE AND INVASIVRE BREAST CANCER. Ann-Katrine Vranso West , Lena Wullkopf, Amalie Christensen, Natascha Leijnse, Jens Magelund Tarp, JoachimMathiesen, Janine Terra Erler, Lene Broeng Oddershede 609-Pos Board B374 INHIBITION OF A DNA REPAIR KINASE ATM LEADS TO CELL DEATH IN 3D MIGRATION INDEPENDENT OF DNA DAMAGE. Yuntao Xia , Jerome Irianto, Charlotte Pfeifer, Roger Greenberg, Dennis Discher 610-Pos Board B375 GENOMIC VARIATION IN AN OSTEOSARCOMA CELL LINE CAUSED BY PORE MIGRATION.  Jerome Irianto , Yuntao Xia, Charlotte R. Pfeifer, Avathamsa Athirasala, Jiazheng Ji, Cory A. Alvey, Manu Tewari, Rachel R. Bennett, Shane M. Harding, Andrea J. Liu, Roger A. Greenberg, Dennis E. Board B376 DIFFUSIVE BEHAVIOR OF MISMATCH REPAIR PROTEIN MSH2 IN CELLS AT DIFFERENT STAGES OF CANCER. Keith D. Bonin , Justin Sigley, John Jarzen, Karin Scarpinato, Martin Guthold, Tracey Pu, Daniel Nelli, Josiah Low 612-Pos Board B377 CHEMOTHERAPY IMPEDES IN VITRO MICROCIRCULATION AND PRO- MOTES MIGRATION OF LEUKEMIC CELLS WITH IMPACT ON METASTA- SIS. Sruti V. Prathivadhi-Bhayankaram , Jianhao Ning, Michael Mimlitz, Carolyn Taylor, Erin Gross, Michael Nichols, Jochen Guck, Andrew E. Ekpenyong Discher 611-Pos

588-Pos Board B353 MG29 INTERACTS WITH BIN1 FOR MAINTAINING T-TUBULE STRUCTURE IN SKELETAL MUSCLE PHYSIOLOGY AND REGENERATION. Xinyu Zhou , Kristyn Gumpper, Xinxin Wang, Junwei Wu, Tao Tan, Miyuki Nishi, Hiroshi Takeshima, Jianjie Ma, Hua Zhu 589-Pos Board B354 PHOSPHORYLATION OF MYOSIN INCREASES THE ATPASE ACTIVITY OF RELAXED SKELETAL MUSCLE FIBERS. Nariman Naber, Roger Cooke Cardiac Muscle Mechanics and Structure I (Boards B355–B369) 590-Pos Board B355 IMPACT OF PARA-NITROBLEBBISTATIN ON HUMAN BETA-CARDIAC MYO- SIN AT THE MOLECULAR AND TISSUE LEVELS. Wanjian Tang, Cheavar Blair, Kenneth S. Campbell, Christopher M. Yengo 591-Pos Board B356 MODULATION OF CARDIAC MYOSIN BY A SMALL MOLECULE AGENT THAT TARGETS THE REGULATORY LIGHT CHAIN. Anu R. Anto , Raja Kawas, Rob- ert Anderson, Marcus Henze, Hector Rodriguez, Danielle Aubele, Jacques Board B357 CARDIAC MYOSIN STRUTURAL KINETICS MODULATED BY SMALL MOL- ECULES.  John A. Rohde , Hyun Cho, Lien Phung, David D. Thomas, Joseph M. Muretta 593-Pos Board B358 FORCE-DEPENDENT RECRUITMENT OF CROSS-BRIDGES FROM THE MYOSIN OFF-STATE CAN CONTRIBUTE TO LENGTH-DEPENDENT ACTIVA- TION. Kenneth S. Campbell , Paul Janssen, Stuart G. Campbell 594-Pos Board B359 DIFFERENCES IN ACTOMYOSIN FUNCTION IN THE LEFT AND RIGHT VEN- TRICLES OF HUMAN HEARTS. Sebasian Requena 595-Pos Board B360 THE FRANK-STARLING MECHANSIM IS ATTENUATED BY A DILATED CARDIOMYOPATHY-ASSOCIATED TROPOMYOSIN MUTATION.  Joseph D. Powers , Farid Moussavi-Harami, Maria Razumova, Jil Tardiff, Michael Board B361 CARDIOMYOPATHY MUTATIONS IN THE CONVERTER DOMAIN OF HU- MAN BETA-CARDIAC MYOSIN IMPAIRS MECHANOCHEMISTRY IN THE PRESENCE AND ABSENCE OF LOAD. Wanjian Tang , Shane D. Walton, William C. Unrath, Christopher M. Yengo 597-Pos Board B362 MAXIMAL FORCE INCREASES AT PHYSIOLOGICAL TEMPERATURE IN MYO- CARDIAL STRIPS FROM NON-FAILING AND FAILING HUMAN HEARTS. Pe- ter O. Awinda, Cheavar A. Blair, Maya E. Guglin, Kenneth S. Campbell, Bertrand C.W. Tanner 598-Pos Board B363 STRUCTURE AND NANOMANIPULATION OF THE TITIN M-LINE COM- PLEX. Zsolt Martonfalvi , Dominik Sziklai, Marton Kovacs, Zsombor Papp, Miklos S. Kellermayer 599-Pos Board B364 PRE-ACTIVATION OF CARDIOMYOCYTES DETERMINES SPEED OF CON- TRACTION: ROLE OF TITIN. Michiel Helmes , Aref Najafi, Martijn van der Locht, Maike Schuldt, Ilse AE Bollen, Max Goebel, Coen Ottenheijm, Jolanda van der Velden, Diederik WD Kuster Mauger 592-Pos Regnier 596-Pos

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