Biophysical Society 61st Annual Meeting | Program Guide

802-Plat 9:00 pm KCNE1-DEPENDENT SUMOYLATION OF K V VOLTAGE-DEPENDENCE OF CARDIAC I KS Leigh D. Plant, Steve A.N. Goldstein 803-Plat 9:15 pm

792-Plat 8:30 am CELLULAR, BIOCHEMICAL AND MOLECULAR CHANGES IN MUSCLES FROM PATIENTS WITH X-LINKED MYOTUBULAR MYOPATHY DUE TO MTM1 MUTATIONS.  Susan Treves , Christoph Bachmann, Heinz Jung- bluth, Francesco Muntoni, Adnan Y. Manzur, Francesco Zorzato 793-Plat 8:45 am ASSEMBLY OF CALCIUM ENTRY UNITS IMPROVES MUSCLE RESISTANCE TO FATIGUE.  Antonio Michelucci , Laura Pietrangelo, Claudia Pecorai, Simona Boncompagni, Feliciano Protasi 794-Plat 9:00 am RYR2 TETRAMER DISTRIBUTIONS IN VENTRICULAR MYOCYTES FROM PHOSPHOMUTANT MICE.  Parisa Asghari , David R.L. Scriven, Yanting Zhao, Roberto Ramos Mondragon, Hector Valdivia, Xander Wehrens, Edwin D.W. Moore 795-Plat 9:15 am MEASURING ELECTRICAL CONDUCTIVITY OF THE CARDIAC T-TUBULAR SYSTEM. Marina Scardigli, Claudia Crocini, Cecilia Ferrantini, Tecla Gab- brielli, Ludovico Silvestri, Raffaele Coppini, Chiara Tesi, Elisabetta Cerbai, Corrado Poggesi, Francesco Pavone, Leonardo Sacconi 796-Plat 9:30 am DHBP REVERSIBLY INHIBITS CALCIUM RELEASE FROM SARCOPLASMIC RETICULUM (SR) IN SKELETAL MUSCLE AND HEART.  Yuriana Aguilar- Sanchez, Marino DiFranco, Yuanzhao L. Darcy, Marbella Quiñonez, Ariel L. Escobar, Julio A. Copello 797-Plat 9:45 am OPTICAL STIMULATION OF IPS CARDIOMYOCYTES ALLOWS BRAND NEW INSIGHTS INTO CONTRACTILITY AND ELECTROPYHSIOLOGY CONJUNC- TIONS.  Sonja Stoelzle-Feix, Matthias Beckler, Patrick Mumm, Ulrich Thomas, Leo Doerr, Elena Dragicevic, Krisztina Juhasz, Corina T. Bot , Michael George, Andrea Brüggemann, Niels Fertig, Jean-Francois Rolland, R. Rizzetto, L. Redaelli, Philipp Sasse 798-Plat 10:00 am HUMAN MESENCHYMAL STEM CELL PARACRINE SIGNALING COUNTER- ACTS HETEROCELLULAR COUPLING EFFECTS ON CARDIAC CONTRACTILITY AND ARRHYTHOMGENICITY.  Joshua Mayourian , Timothy J. Cashman, Bryce V. Johnson, David M. Sachs, Deepak A. Kaji, Eric A. Sobie, Kevin D. Costa Platform Voltage-gated K Channels and Mechanisms of Voltage Sensing and Gating II 8:15 pm - 10:15 am, Room R06/07 Co-Chairs Karen M. Callahan, University of Chicago Cui Jianmin, Washington University 799-Plat 8:15 pm NON-CANONICAL INTERACTIONS BETWEEN VOLTAGE SENSORS AND PORE DOMAIN IN SHAKER K + -CHANNEL.  João Carvalho-de-Souza , Fran- cisco Bezanilla 800-Plat 8:30 pm VOLTAGE SENSING IN HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEO- TIDE GATED (HCN) CHANNELS.  Karen M. Callahan , Nazzareno D’Avanzo 801-Plat 8:45 pm THE TARANTULA TOXIN GUANGXITOXIN-1E TRAPS K + CHANNEL VOLTAGE SENSOR IN A FULLY RESTING CONFORMATION.  Drew C. Tilley , Kenneth S. Eum, Jon T. Sack

7.1 SUBUNITS DETERMINES THE CHANNELS.  Dazhi Xiong , Tian Li,

M O N D A Y

THE TRANSITIONS BETWEEN TWO OPEN STATES OF THE KCNQ1 POTAS- SIUM CHANNEL PRODUCE INACTIVATION-LIKE PHENOTYPE.  Panpan Hou , Mark A. Zaydman, Jingyi Shi, Ling Zhong, Kelli McFarland, Jianmin Cui 804-Plat 9:30 pm KV1.2 CHANNELS AT THE INTERFACE OF REDOX AND ELECTRICAL EXCITABILITY.  Victoria A. Baronas , Runying Yang, Harley T. Kurata 805-Plat 9:45 pm MOLECULAR SIMULATIONS OF ION PERMEATION IN POTASSIUM CHANNELS. Wojciech Kopec , Bert de Groot 806-Plat 10:00 pm DOES PROTON CONDUCTION IN THE VOLTAGE-GATED PROTON CHANNEL HH V 1 INVOLVE GROTTHUS HOPPING VIA ACIDIC RESIDUES?  Lucie Delemotte , Siri van Keulen, Ursula Roethlisberger, Eleonora Gianti, Vin- cenzo Carnevale, Michael L. Klein Platform Cardiac Muscle Mechanics and Structure 8:15 am - 10:15 am, Room R08/09 Co-Chairs INDEPENDENT STOCHASTIC BURST-LIKE TRANSCRIPTION OF MUTANT AND WILDTYPE ALLELES AS MECHANISM FOR CELL-TO-CELL FUNCTIONAL IMBALANCE IN HYPERTROPHIC CARDIOMYOPATHY.  Ante Radocaj , Kath- rin Kowalski, Judith Montag, Theresia Kraft, Bernhard Brenner 808-Plat 8:30 am UNCOVERING THE MOLECULAR INTERACTIONS THAT MAINTAIN THE SEQUESTERED STATE OF MYOSIN AND THEIR IMPLICATION IN HYPER- TROPHIC CARDIOMYOPATHY.  Darshan V. Trivedi , Suman Nag, Saswata S. Sarkar, Arjun S. Adhikari, Shirley Sutton, Kathleen M. Ruppel, James A. 8:45 am STRUCTURAL AND BIOPHYSICAL ANALYSIS OF HYPERTROPHIC CARDIO- MYOPATHY-LINKED TITIN MISSENSE VARIANTS. Martin Rees , Franca Fraternali, Perry Elliott, Mathias Gautel 810-Plat 9:00 am NANOMECHANICAL PHENOTYPES IN HYPERTROPHIC CARDIOMYOPATHY CAUSED BY MISSENSE MUTATIONS IN CARDIAC MYOSIN-BINDING PRO- TEIN C.  Carmen Suay-Corredera, Elías Herrero-Galán, Diana Velázquez- Carreras, Íñigo Urrutia-Irazábal, Diego García-Giustiniani, Javier Delgado, Luis Serrano, Pablo García-Pavía, Lorenzo Monserrat, Jorge Alegre-Cebollada 811-Plat 9:15 am Education Travel Awardee GENETICALLY ENGINEERED HUMAN STEM CELL-DERIVED CARDIOMYO- CYTES TO STUDY THE FUNCTIONALITY OF CRONOS TITIN.  Rebecca J. Zaunbrecher , Kevin Beussman, Andrea Leonard, Lil Pabon, Hans Reinecke, Nathan Sniadecki, Michael Regnier, Charles Murry 812-Plat 9:30 am ENGINEERED TROPONINS MODULATE THE CA 2+ SENSITIVITY OF THE FAIL- ING HUMAN MYOCARDIUM.  Cheavar A. Blair , Jonathan Davis, Brandon Biesiadecki, Kenneth Campbell Spudich 809-Plat Douglas D. Root, University of North Texas Jorge Alegre-Cebollada, Columbia University 807-Plat 8:15 am

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