Biophysical Society 61st Annual Meeting | Program Guide

856-Plat 12:30 pm GIRK4 MUTATIONS R52H AND E246K IMPAIR CHANNEL GATING BUT NOT INWARD RECTIFICATION.  Boris Shalomov , Haritha P. Reddy, Amal Kanti Bera, Nathan Dascal Platform Membrane Physical Chemistry II 10:45 am - 12:45 pm, Room R08/09 Co-Chairs Gerald W. Feigenson, Cornell University Stephanie Tristram-Nagle, Carnegie Mellon University 857-Plat 10:45 am ELUCIDATING PI(4,5)P 2 AQUEOUS MICELLE BEHAVIOR AND PI(4,5)P 2 CLUSTER FORMATION IN AN INNER LEAFLET MODEL MEMBRANE.  Yi Wen , Volker M. Vogt, Gerald W. Feigenson 858-Plat 11:00 am HIV-1 MATRIX-31 MEMBRANE BINDING PEPTIDE INTERACTS DIFFERENTLY WITH MEMBRANES CONTAINING PS VS. PI(4,5)P 2 .  Lauren O’Neil, Kathryn Andenoro, Isabella Pagano, Laura Carroll, Leah Langer, Zachary Dell, Davina Perera, Bradley W. Treece, Frank Heinrich, Mathias Loesche, John Nagle, Stephanie Tristram-Nagle 859-Plat 11:15 am STABILITY OF CHARGED MEMBRANES: THE ROLE OF PORE EDGE TEN- SION.  Rafael B. Lira, Rumiana Dimova, Karin A. Riske 860-Plat 11:30 am DETERMINING INTERACTIONS OF CATIONIC MEMBRANE NANOPAR- TICLES WITH HYDROPHOBIC DRUG CARGO AND THEIR MECHANISMS OF DRUG DELIVERY TO CELLS.  Victoria Steffes , Meena Murali, Kai K. Ewert, Cyrus R. Safinya 861-Plat 11:45 am BILAYER DEFECTS FACILITATE DPPC FLIP-FLOP.  DrewMarquardt , Freder- ick A. Heberle, Tatiana Miti, John Katsaras, Georg Pabst 862-Plat 12:00 pm NANOMETER-SCALE LIPID CLUSTERS IN MODEL MEMBRANES REVEALED BY ATOMIC RECOMBINATION IN NANOSIMS.  Frank R. Moss , Steven G. Boxer 863-Plat 12:15 pm EFFECTS OF SILICA SUPPORT ON DYNAMICS OF TRANSMEMBRANE PEP- TIDES AND EFFECTIVE PKA OF IONISABLE SIDECHAINS.  Erkang Ou, Maxim Voinov, Alex I. Smirnov, Tatyana I. Smirnova 864-Plat 12:30 pm TOTAL REFLECTION X-RAY FLUORESCENCE AT THE AIR WATER INTERFACE USING XERAY.  Zhiliang Gong , Daniel Kerr, Hyeondo L. Hwang, J. Michael Henderson, Tiffany Suwatthee, Benjamin R. Slaw, Kathleen D. Cao, Binhua Lin, Wei Bu, Ka Yee C. Lee Platform Molecular Dynamics I 10:45 am - 12:45 pm, Room 206/207 Co-Chairs Lee Makowski, Northeastern University Sarah Rauscher, Max Planck Institute for Biophysical Chemistry, Germany 865-Plat 10:45 am DEVELOPING FORCE FIELDS FOR THE ACCURATE SIMULATION OF BOTH ORDERED AND DISORDERED PROTEIN STATES.  Paul Robustelli , Stefano Piana, David E. Shaw

866-Plat 11:00 am CHARMM36M: AN IMPROVED FORCE FIELD FOR FOLDED AND INTRINSI- CALLY DISORDERED PROTEINS.  Jing Huang, Sarah Rauscher , Grzegorz Nawrocki, Ting Ran, Michael Feig, Bert L. de Groot, Helmut Grubmüller, Alexander D. MacKerell, Jr. 867-Plat 11:15 am VERIFYING SELF-CONSISTENCY OF PROTEIN STRUCTURE AND DYNAMICS THROUGH MD SIMULATION AND WAXS.  Hao Zhou , Hugo Guterres, Carla Mattos, Lee Makowski 868-Plat 11:30 am ATOM-RESOLVED VIEW OF A CELL ORGANELLE ON A COMPUTATIONAL MICROSCOPE.  Abhishek Singharoy , Klaus Schulten 869-Plat 11:45 am AS SIMPLE AS POSSIBLE BUT NOT SIMPLER: ON THE RELIABILITY OF PROTEIN COARSE-GRAINED MODELS. Mona Habibi , Joerg Rottler, Steven 12:00 pm IMPROVED CHARMM ADDITIVE FORCE FIELD PARAMETERS TO ACCU- RATELY MODEL TYROSINE-CHOLINE CATION-Π INTERACTIONS.  Hanif Muhammad Khan , Cédric Grauffel, Ria Broer, Alexander D. MacKerell Jr., Remco W. A. Havenith, Nathalie Reuter 871-Plat 12:15 pm GROMEX: ELECTROSTATICS WITH CHEMICAL VARIABILITY FOR REALISTIC MOLECULAR SIMULATIONS ON THE EXASCALE.  R. Thomas Ullmann , Carsten Kutzner, Andreas Beckmann, Bartosz Kohnke, David Haensel, Ivo Kabadshow, Holger Dachsel, Berk Hess, Helmut Grubmüller 872-Plat 12:30 pm A HYBRID ALL-ATOM/COARSE-GRAINED APPROACH TO PROBLEMS IN CHEMISTRY AND BIOLOGY.  Samuel Genheden Platform Protein Structure and Conformation II 10:45 am - 12:45 pm, Room 208/209 Co-Chairs Kelly A. Jenkins, Rensselaer Polytechnic Institute David Sehnal, Central European Institute of Technology, Czech Republic 10:45 am USING HYDROGEN BOND SURROGATE TECHNOLOGY TO STABILIZE BETA- HAIRPINS.  Nicholas Sawyer , Paramjit S. Arora 874-Plat 11:00 am SINGLE-MOLECULE FRET DELINEATES ASYMMETRIC TRIMER CONFORMA- TIONS DURING HIV-1 ENTRY.  Xiaochu Ma, Maolin Lu , Daniel S. Terry, Jason Gorman, Peter D. Kwong, Scott C. Blanchard, James B. Munro, Walther Mothes 875-Plat 11:15 am LIPID REGULATED INTRAMOLECULAR CONFORMATIONAL DYNAMICS OF SNARE-PROTEIN YKT6.  Yawei Dai, Markus Seeger, Jingwei Weng, Song Song, Wenning Wang, Yan-Wen Tan 876-Plat 11:30 am Education Travel Awardee THE TWO GTPASE DOMAINS OF THE OUTER MITOCHONDRIAL MEM- BRANE PROTEIN MIRO HAVE NOVEL ACTIVE SITE CONFORMATIONS AND DISTINCT BIOCHEMICAL PROPERTIES.  Kyle P. Smith , Pamela J. Focia, Yongbo Zhang, Julian L. Klosowiak, Douglas M. Freymann, Sarah E. Rice 877-Plat 11:45 am CAVITIES AND COOPERATIVITY IN THE FOLDING OF THE LEUCINE RICH REPEAT PROTEIN PP32: A PRESSURE-JUMP FLUORESCENCE AND HIGH PRESSURE NMR STUDY.  Kelly A. Jenkins , Martin Fossat, Thuy Dao, Yi Zhang, Zackery White, Doug Barrick, Catherine A. Royer S. Plotkin 870-Plat 873-Plat

M O N D A Y

57