Biophysical Society 61st Annual Meeting | Program Guide

Exhibitor Presentation Nanion Technologies GmbH 12:30 pm - 2:00 pm, Room 221 Ion Channel Drug Discovery - Beyond the Bottlenecks and Ready for CiPA

878-Plat 12:00 pm REAL-TIME INTERACTIVE VISUALISATION OF LARGE MACROMOLECULAR ASSEMBLIES AND MOLECULAR MACHINES AT ATOMIC RESOLUTION.  David Sehnal , Mandar Deshpande, Radka Svobodova Varekova, Saquib Mir, Karel Berka, AdamMidlik, Lukas Pravda, Sameer Velankar, Jaroslav Koca 879-Plat 12:15 pm STRUCTURAL BASIS FOR THE DISSOCIATION OF ALPHA-SYNUCLEIN FIBRILS TRIGGERED BY PRESSURE PERTURBATION OF THE HYDROPHOBIC CORE.  Guilherme A. P. de Oliveira , Mayra A. Marques, Yraima Cordeiro, Caroline Schuabb, Adolfo H. Moraes, Roland Winter, Hartmut Oschkinat, Debora Foguel, Mônica S. de Freitas, Jerson L. Silva 880-Plat 12:30 pm CO-TRANSCRIPTIONAL RIBOSOME ASSEMBLY IN REAL-TIME.  Olivier Duss , Seán O’Leary, Jody Puglisi, James Williamson Career Center Workshop Demystifying the Academic Job Search II: Preparing Your Written Application Materials: CV, Cover Letter, and Research Statement 11:30 am - 12:30 am, Room 212/213 Your written application materials are typically the only information a search committee will have before them as they make the vast majority of cuts. Learn how to craft credentials that speak clearly and powerfully on your behalf, and help committees understand the potential contribu- tion you have to offer. Exhibitor Presentation Asylum Research, an Oxford Instruments Company 11:30 am - 1:00 pm, Room 218 Now Playing: Video-Rate AFM with the New Cypher VRS Atomic Force Microscope Join our free lunch and learn as we introduce the first and only full-fea- tured, video-rate AFM for imaging biological processes— the Cypher VRS Atomic Force Microscope. The Cypher VRS enables high resolution video- rate imaging at 625 lines per second with incredibly easy operation and modularity to support other modes and environmental accessories. The Cypher VRS is capable of imaging samples at 10 frames per second with unprecedented resolution for clearly observing dynamics such as the action of restriction enzymes digesting DNA molecules. Perfusion can also be performed during experiments to observe growth crystal in real time and molecular arrangements of self-assembled monolayers (SAMs).  All the ease-of-use features of the industry-leading Cypher ES AFM increase productivity such as automated laser positioning, cantilever calibra- tion, and blueDriveTM photothermal excitation for stable imaging and quantitative measurements. No other AFM can match the combined performance of video-rate speed, high resolution and versatility. Learn all the details about Cypher VRS and be entered in our iPad drawing (must be present to win). See it in action in Booth 608. Speaker Iréne Revenko, Product Manager, Asylum Research, an Oxford Instru- ments Company

M O N D A Y

Nanion Technologies is one of the leading providers of automated patch clamp systems, offering a diverse product portfolio for experiments ran- ging from single channel recordings to HTS-compatible ion channel drug discovery. During this workshop, we will demonstrate how to push the boundaries of patch clamp-based ion channel high throughput screening projects of various voltage- and ligand gated targets, and how to get ready for CiPA-compliant safety screening beyond hERG. The CIPA initiative is an ongoing validation program aimed at impro- ving the regulatory requirements for proarrhythmia risk assessment. In accordance with the CiPA-initiative, the panel of cardiac ion channels to consider will drastically expand, consequently requiring increased data throughput for early compound safety prediction. The SyncroPatch 384/768PE, an automated patch clamp platform recor- ding from up to 768 cells simultaneously, allows the highest data through- put on the market supporting HTS of ion channel active compounds and early safety assessment on cardiac channels. Data of six different cardiac channels recorded in the voltage clamp mode, using one single plate, will be shown. The SyncroPatch 384/768PE also supports automated current clamp recordings, experiments at physiological temperature, and minimal cell usage, making it the ideal partner for safety testing on stem cell-derived cardiomyocytes. The CardioExcyte 96 is a hybrid system combining impedance and EFP recordings from beating cardiomyocyte networks from 96 wells in paral- lel. The CardioExcyte 96 has proven a versatile tool for safety and toxicity screening applications serving as a powerful tool complementing APC. Join our workshop to learn more about new safety screening strategies and how to keep up with the increasing demands on cardiac safety and toxicity screening. Space is limited so reserve yours by sending an email to info@nanion.de. Speakers Andrea Brüggemann, CSO, Nanion Technologies GmbH Niels Fertig, CEO, Nanion Technologies GmbH Markus Rapedius, Senior Scientist, Nanion Technologies GmbH

Industry Panel: Breaking Into Industry 1:30 pm - 3:00 pm, Rivergate Room, Lobby Level

Are you interested in pursuing a career in industry? Stop by to hear from a panel of experts who work in bio-related industries. Panelists will dis- cuss how to find, select, and apply for industry internships, as well as the skills that industry is looking for in job applicants. This panel will provide attendees with useful tools and resources.

Exhibitor Presentation Malvern Instruments 1:30 pm - 3:00 pm, Room 218 Molecular Interactions of Proteins & Small Molecules

Factors describing the stability of any protein formulating can gener- ally be classified into two areas, conformational stability and colloidal stability. Conformational stability relates to the intrinsic properties of a protein molecule and can be described by a range of parameters such as melting point, enthalpy, aggregation onset temperature, and composition of aggregate. These parameters can be observed using many traditional techniques such as Differential Scanning Calorimetry (DSC), Dynamic Light Scattering (DLS), and Size Exclusion Chromatography (SEC).

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