Biophysical Society 61st Annual Meeting | Program Guide

1158-Pos Board B226 ELECTROPHYSIOLOGICAL EFFECTS OF TRIGGERED CALCIUMWAVES ON THE ACTION POTENTIAL IN LEFT ATRIAL MYOCYTES FROM NORMAL AND FAILING DOG HEART. Georg Gussak , Gary L. Aistrup, WilliamMarszalec, Yohannes Shiferaw, J. AndrewWasserstrom 1159-Pos Board B227 ELECTRONIC EXPRESSION OF I K1 IN HUMAN INDUCED PLURIPOTENT STEM CELL DERIVED CARDIAC MYOCYTES (HIPSCD-CM) ALTERS ACTION POTEN- TIAL RESPONSE TO CHANNEL BLOCK. Mark Nowak, Sanjot Singh, Aidan Coon, Shimin Wang, Glenna Bett, Randall L. Rasmusson 1160-Pos Board B228 CHARACTERIZATION OF IPS DERIVED CARDIOMYOCYTES IN VOLTAGE CLAMP AND CURRENT CLAMP BY AUTOMATED PATCH CLAMP. Andrea Brüggemann , Claudia Haarmann, Markus Rapedius, Tom Goetze, Ilka Rinke, Michael George, Niels Fertig 1161-Pos Board B229 PHARMACOLOGICAL IDENTIFICATION OF AN L-TYPE CALCIUM CHAN- NEL IMPEDANCE SIGNAL IN HUMAN INDUCED PLURIPOTENT STEM-CELL DERIVED CARDIOMYOCYTES. Carlos A. Obejero-Paz , Leslie Ellison, James Kramer, Arthur M. Brown, Andrew Bruening-Wright 1162-Pos Board B230 VOLTAGE-SENSITIVE ICG FLUORESCENCE IMAGING. Regina Macianskiene , Mante Almanaityte, Rimantas Treinys, Irma Martisiene, Antanas Navalinskas, Rimantas Benetis, Jonas Jurevicius Muscle Regulation (Boards B231–B236) 1163-Pos Board B231 AN OBSEVATION OF NATIVE SKELETAL THIN FILAMENT STRUCTURE AT HIGH CALCIUM CONDITION BY ELECTRON CRYOMICROSCOPY. Fa-Qing Zhao 1164-Pos Board B232 COOPERATIVE CHANGES IN TROPONIN STRUCTURE EXPLAINED WITHOUT COOPERATIVE CALCIUM BINDING. Henry G. Zot , Javier E. Hasbun 1165-Pos Board B233 THE ORIGIN OF THE FORCE INCREASE OBSERVED AFTER ACTIVE STRETCH BEYOND MYOFILAMENT OVERLAP IN SINGLE MUSCLE FIBERS. Shuyue Liu , Venus Joumaa, Walter Herzog 1166-Pos Board B234 DETECTION OF SMALL-MOLECULE MODULATORS OF ACTIN-MYOSIN STRUCTURE AND FUNCTION USING HIGH-THROUGHPUT TIME-RESOLVED FRET. Piyali Guhathakurta , Ewa Prochniewicz, Kurt C. Peterson, Benjamin D. Grant, Gregory D. Gillispie, David D. Thomas 1167-Pos Board B235 CARDIAC TISSUE ORGANIZATION AND CONTRACTILITY. Jasmine Naik, Meghan Knight, Nancy Drew, Nicholas Johnsen, Anna Grosberg 1168-Pos Board B236 PROBING ESTRADIOL EFFECTS ON SUPER-RELAXED MYOSIN IN MUSCLE FIBERS WITH FLUORESCENCE. Lien A. Phung , Joseph M. Muretta, Karl J. Petersen, John A. Rohde, Tara L. Mader, Dawn A. Lowe, David D. Thomas Intracellular Transport (Boards B237–B248) 1169-Pos Board B237 COMPUTATIONAL ANALYSIS OF WHOLE-CELL SCALE DISTRIBUTIONS AND INTERACTIONS OF INTRACELLULAR ORGANELLE NETWORKS. Qinle Ba, Guruprasad Raghavan, Hao-Chih Lee, Ge Yang

1146-Pos Board B214 CALMODULIN REGULATION OF RYANODINE RECEPTORS (RYR2) DEPENDS ON RYR2 PHOSPHORYLATION AT RESIDUES S2808 AND S2814. Nieves Gomez-Hurtado , Kafa Walweel, Derek Laver, Bjorn C. Knollmann 1147-Pos Board B215 NOVEL LUMINAL REGULATION OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR CHANNEL GATING. Horia Vais, J. Kevin Foskett, Don-On Daniel Mak 1148-Pos Board B216 MONITORING CALCIUM ACTIVITY IN INTACT ISLET OF LANGHERANS Α-CELLS USING A GENETICALLY ENCODED BIOSENSOR AND LIGHT-SHEET ILLUMINATION MICROSCOPY. Zeno Lavagnino , David W. Piston 1149-Pos Board B217 ANISOTROPIC DIFFUSION OF PROTEINS IN THE SARCOPLASMIC RETICU- LUM OF SKELETAL MUSCLE. Carlo D. Manno , Lourdes C. Figueroa, Dirk Gillespie, ChulHee Kang, Clara Franzini-Armstrong, Eduardo Rios Cardiac, Smooth, and Skeletal Muscle Electrophysiology I (Boards B218–B230) 1150-Pos Board B218 THE SODIUM CHANNEL AUXILIARY SUBUNIT Β1 IS STRUCTURALLY CRITICAL FOR CARDIAC CONDUCTION: EVIDENCE FROM THE SINGLE MOLECULE SCALE TO THE WHOLE ORGAN. Rengasayee Veeraraghavan , Gregory S. Hoeker, Steven Poelzing, Robert G. Gourdie 1151-Pos Board B219 BIOPHYSICAL AND MOLECULAR COMPARISON OF SODIUM CURRENT IN CELLS ISOLATED FROM CANINE ATRIA AND PULMONARY VEIN. Hec- tor Barajas-Martinez, Robert J. Goodrow, Dan Hu, Payal Patel, Brian K. Panama, Jacqueline A. Treat, Jonathan M. Cordeiro 1152-Pos Board B220 EFFECTS OF KINETICS AND STATE-DEPENDENT BINDING PROPERTIES OF I KUR TARGETING DRUGS ON ATRIAL ELECTROPHYSIOLOGY. Nicholas Ellinwood , Stefano Morotti, Eleonora Grandi 1153-Pos Board B221 A DUAL POTASSIUM CHANNEL ACTIVATOR IMPROVES REPOLARIZATION RESERVE AND NORMALIZES VENTRICULAR ACTION POTENTIALS. Kirstine Calloe , José M. Di Diego, Rie S. Hansen, Shea Nagle, Jacqueline A. Treat, Jonathan M. Cordeiro 1154-Pos Board B222 DYSFUNCTION OF INWARD RECTIFIER POTASSIUM CHANNEL IN RBM20-/- RATS. Bi-Hua Tan , Wei Guo, Chunhua Song, Marion Greaser 1155-Pos Board B223 A NEW CLASS OF ANTIARRHYTHMICS FOR LATE I CA,L . Marina Angelini , Arash Pezhouman, Nicoletta Savalli, Antonios Pantazis, Hrayr S. Karagueu- zian, James N. Weiss, Riccardo Olcese 1156-Pos Board B224 A RARE SK2 CHANNEL VARIANT CONFERS A GAIN-OF-FUNCTION PHENO- TYPE. Zhuo Wang , Jum-Suk Ko, Matteo Vatta, Patricia Celestino-Soper, Ty C. Lynnes, Peng-Sheng Chen, Michael Rubart 1157-Pos Board B225 ATRIAL FIBRILLATION IN HYPERTENSIVE HEART DISEASE IS ASSOCIATED WITH DISTINCT PATTERNS OF ELECTRICAL REMODELING IN THE LEFT AND RIGHT ATRIA. Hailey J. Jansen , Emmanuel E. Egom, Sara A. Rafferty, Robert A. Rose

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