Biophysical Society 61st Annual Meeting | Program Guide

1183-Pos Board B251 TARANTULA TOXIN SGTX-1 ALTERS GATING KINETICS OF HUMAN VOLTAGE-GATED SODIUM CHANNEL NAV1.7.  Ian H. Kimball , Phuong T. Nguyen, Jenny Yam, Brandon Pressly, Royce York, Jon T. Sack, Vladimir Yarov-Yarovoy 1184-Pos Board B252 BIOPHYSICAL, MOLECULAR, AND PHARMACOLOGICAL CHARACTERIZA- TION OF NA V CHANNELS FROM INDUCED PLURIPOTENT STEM CELL- DERIVED CARDIOMYOCYTES. Adrien Moreau, Aurélie Mercier, Mohamed Chahine 1185-Pos Board B253 SODIUM CURRENT ANALYSIS IN MYOCYTES OBTAINED FROM HUMAN INDUCED PLURIPOTENT STEM CELLS AND NATIVE ADULT HEART. Robert J. Goodrow, Suveer Desai, Mayurika Desai, Jonathan M. Cordeiro 1186-Pos Board B254 MIXED PERIODIC PARALYSIS & MYOTONIA MUTANT IMPARTS PH SENSI- TIVITY IN NAV1.4. Mohammad-Reza Ghovanloo , Peter C. Ruben 1187-Pos Board B255 CNV1014802 RESCUES THE PAROXYSMAL EXTREME PAIN DISORDERS NA V 1.7 MUTANTS BY RESTORING IMPAIRED INACTIVATION. Yueming Zheng , Wanfu Wang, Zhaobing Gao 1188-Pos Board B256 ORIENTED CIRCULAR DICHROISM SPECTROSCOPY AS A TOOL FOR STUDYING THE GATING OF SODIUM CHANNELS. Matthew Colledge , B.A. Wallace 1189-Pos Board B257 EPHAPTIC EFFECTS POTENTIATE THE THRESHOLD BEHAVIOR OF THE CAR- DIAC SODIUM CURRENT IN A HIGH RESOLUTION MATHEMATICAL MODEL OF A NARROW INTERCELLULAR CLEFT. Echrak Hichri , Hugues Abriel, Jan Board B258 BETA-POMPILIDOTOXIN ADOPTS A DISTINCT 3D STRUCTURE WHEN BOUND TO NAV1.2DIVS3-S4 PADDLE MOTIF. Meero Yeu , Boris Arshava, Jianqin Zhuang, Sébastien F. Poget 1191-Pos Board B259 THE STRUCTURAL CHARACTERIZATION OF THE HUMAN CARDIAC SO- DIUM CHANNEL VOLTAGE-SENSOR DOMAIN IV PADDLE MOTIF.  Mohammed H. Bhuiyan , Adel K. Hussein, Boris Arshava, Jianqin Zhuang, James Aramini, Fred Naider, Sébastien F. Poget 1192-Pos Board B260 VIRTUAL SCREENING IN SEARCH OF ALLOSTERIC MODULATORS OF NAV1.1 CHANNELS.  Johnathan Wong , Syed R. Ali, Paul Wadsworth, Ad- itya K. Singh, Zhiqing Liu, Haiying Chen, Jia Zhou, Fernanda Laezza 1193-Pos Board B261 TUNING THE ION SELECTIVITY OF TWO-PORE CHANNELS.  Jiangtao Guo , Weizhong Zeng, Youxing Jiang 1194-Pos Board B262 MAPPING PROTEIN: PROTEIN INTERACTION OF THE FGF14:GSK3Β COM- PLEX. Aditya K. Singh , Paul A. Wadsworth, Fernanda Laezza 1195-Pos Board B263 ESTIMATING KINETIC MECHANISMS WITH PRIOR KNOWLEDGE. Autoosa Salari, Zachary F. Elkins, Marco A. Navarro, Benton R. Berigan, Jenna L. Lin, Mirela Milescu, Lorin S. Milescu 1196-Pos Board B264 ATRIAL-VENTRICULAR DIFFERENCES IN VOLTAGE-GATED NA + CURRENTS OF RABBIT CARDIOMYOCYTES. Rachel E. Caves , Hongwei Cheng, Stéph- anie C. Choisy, Hanne C. Gadeberg, Simon M. Bryant, Jules C. Hancox, Andrew F. James P. Kucera 1190-Pos

1170-Pos Board B238 A CONFOCAL SUPER-RESOLUTION APPROACH TO STUDY THE DYNAMICS OF GOLGI APPARATUS IN LUNG CANCER METASTASIS. Priyam Banerjee , Xiaochao Tan, Jonathan M. Kurie 1171-Pos Board B239 GOLGI MICROTUBULES ARE HYPER-ACETYLATED AND PARTICIPATE IN FAST CARGO TRAFFICKING. Huiwen Hao , Qian Su, Shujuan Zhao, Yujie Sun 1172-Pos Board B240 KIF5A IS RESPONSIBLE FOR COLLAGEN TRANSPORT OF MYOFIBROBLASTS DURING PLEURAL FIBROSIS. Yoshikazu Tsukasaki , Hirotoshi Kamata, Julia Wang, Tsuyoshi Sakai, Reiko Ikebe, Ann Jeffers, Boren Jake, Shuzi Owens, Masaaki Higashihara, Steven Idell, Torry Tucker, Mitsuo Ikebe 1173-Pos Board B241 CARGO-MEDIATED REGULATION OF COLLECTIVE MYOSIN VI MOTIL- ITY. Ashim Rai , Ruth Sommese, Tejas Gupte, Sivaraj Sivaramakrishnan 1174-Pos Board B242 TRIM FAMILY PROTEINS IN INTRACELLULAR VESICLE TRAFFICKING. Kristyn Gumpper , Ki Ho Park, Mingzhai Sun, Pei-Hui Lin, Tao Tan, Miyuki Nishi, Hiroshi Takeshima, Jianjie Ma 1175-Pos Board B243 MEMBRANE BINDING AND REMODELLING BY THE COPII COAT. Sebastian Daum, Mona Grimmer, Jan Ebenhan, Annette Meister, Jan Auerswald, Daniela Kruger, Stefan Werner, Kirsten Bacia 1176-Pos Board B244 STRIKING THE BALANCE BETWEEN SELECTIVITY AND EFFICIENCY: AN IN- TEGRATIVE MODEL OF NUCLEOCYTOPLASMIC TRANSPORT. Barak Raveh , Jerome Karp, Samuel Sparks, Benjamin Timney, David Cowburn, Michael P. Rout, Andrej Sali 1177-Pos Board B245 BACTERIAL CARBOXYSOME SHELL PROTEINS ARE SELECTIVELY PERME- ABLE TO CARBON FIXATION SUBSTRATES. Paween Mahinthichaichan , Dylan Morris, Yi Wang, Grant J. Jensen, Emad Tajkhorshid 1178-Pos Board B246 EVIDENCE OF A TRANSITION FROM DIFFUSIVE TO SUPER-DIFFUSIVE MOTION OF CELLULOSE SYNTHASE COMPLEXES IN LIVING PLANTS. Nina Zehfroosh , Derui Liu, Brandon Hancock, Tobias I. Baskin, Lori S. Goldner 1179-Pos Board B247 PROTEIN CHARGE AND ION CONCENTRATION AFFECT PROTEIN DIFFU- SION IN THE PROKARYOTIC CYTOPLASM. Wojciech M. Smigiel , Paul E. Schavemaker, Bert Poolman 1180-Pos Board B248 EMERGENT SELF-SIMILARITY IN COMPLEX BIOLOGICAL SYSTEMS DUE TO STRONG DISORDER. Paul A. Wiggins , Stella Stylianidou Voltage-gated Na Channels II (Boards B249–B264) 1181-Pos Board B249 HIGH-THROUGHPUT SCREENING OF NA V 1.7 SODIUM CHANNEL BLOCK- ERS IN AN AUTOMATED PATCH CLAMP ASSAY. Tianbo Li , Gang Lu, Tania Chernov-Rogan, Jun Chen 1182-Pos Board B250 POSITIVE MODULATION OF HUMAN NAV CHANNELS BY PYRE- THROIDS. Wolf Berger, Kirsty M. Rooney, Henning J. Draheim

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