Biophysical Society 61st Annual Meeting | Program Guide

1260-Pos Board B328 N-TERMINAL TRUNCATION OF CARDIAC TROPONIN I COMPENSATES FOR DIASTOLIC DYSFUNCTION OF MOUSE HEARTS INDUCED BY ACUTE PRES- SURE OVERLOAD. Li-Fei Liu , Han-Zhong Feng, J.-P. Jin 1261-Pos Board B329 FUNCTIONAL SIGNIFICANCE OF C-TERMINAL MOBILE DOMAIN OF CARDIAC TROPONIN I. Nazanin Bohlooli Ghashghaee , Peter O. Awinda, Bertrand C.W Tanner, Wen-Ji Dong 1262-Pos Board B330 IMPACT OF CGMP-PKG PATHWAY MODULATION ON TITIN PHOSPHORYLA- TION AND TITIN-BASED MYOCARDIAL PASSIVE STIFFNESS. Nazha Hamdani , Melissa Herwig, Soraya Hoelper, Marcus Krueger, Doris Koes- ling, Michaela Kuhn, Wolfgang A. Linke 1263-Pos Board B331 SARCOMERE LENGTHDEPENDENT EFFECTS ON THE CA 2+- TROPONIN REGULATION IN SKINNED MYOCARDIAL FIBERFROM TITIN RBM20 DELETION MICE. King-Lun Li, Mei Methawasin, Henk Granzier, Ross John Solaro, Bertrand Tanner, Wen-Ji Dong 1264-Pos Board B332 ACTIVATION AND INHIBITION OF CARDIAC THIN FILAMENTS BY SINGLE AND MULTIPLE DOMAINS CONSTRUCTS OF HUMAN CARDIAC MYOSIN BINDING PROTEIN-C (CMYBP-C) AT LOW CALCIUM. Betty Virok, Samantha Harris, Vitold E. Galkin, Howard D. White 1265-Pos Board B333 COMPARISON OF THE REGULATION OF CONTRACTION IN INSECT FLIGHT MUSCLE AND VERTEBRATE CARDIAC MUSCLE. Belinda Bullard , Demetris Koutalianos, Kate English, Kevin Leonard 1266-Pos Board B334 CHARACTERIZATION OF A TRUNCATED CARDIAC MYOSIN-BINDING PRO- TEIN C MUTATION USING PATIENT-DERIVED ENGINEERED HEART TISSUE AND COMPUTATIONAL MODELING.  Jonas Schwan , Yongming Ren, Daniel L. Jacoby, Yibing Qyang, Stuart G. Campbell 1267-Pos Board B335 TIME-COURSE OF CARDIAC MYOFIBRILLAR CONTRACTILE PROPERTIES DURING THE PROGRESSION OF RAT HYPERTENSIVE HEART FAILURE.  Laurin M. Hanft , Craig A. Emter, Kerry S. McDonald 1268-Pos Board B336 PROTEOMIC AND IMMUNOHISTOLOGICAL CHARACTERIZATION OF CYTOSKELETAL ALTERATIONS DURING THE PROGRESSION OF HUMAN CARDIOMYOPATHY. Chrisitna Y. Chen , Alexey Bogush, Kenneth Margulies, Benjamin L. Prosser 1269-Pos Board B337 HYPERTROPHIC CARDIOMYOPATHY MUTATIONS DESTABILIZE THE SUPER- RELAXED STATE OF MYOSIN. Robert L. Anderson , Roger Cooke, James A. Spudich, Eric M. Green 1270-Pos Board B338 INVESTIGATION OF THE MOLECULAR INTERACTIONS REGULATING THE FUNCTION OF HUMAN CARDIAC MYOSIN. Saswata S. Sarkar , Darshan Trivedi, Arjun S. Adhikari, Chao Liu, Kathleen M. Ruppel, James A. Spudich 1271-Pos Board B339 D292V ACTIN MUTATION STABILIZES TROPOMYOSIN IN THE OFF-STATE OF THE THIN FILAMENT.  Jeffrey R. Moore , Thavanareth Prum, Patricia M. Fagnant, Kathleen M. Trybus, William Lehman 1272-Pos Board B340 STEP-WISE TRUNCATION OF THE C-TERMINAL 14 RESIDUES OF TROPO- NIN T REDUCES THE B STATE OF REGULATED ACTIN AND ENHANCES THE M STATE. Dylan Johnson, William Angus, Joseph M. Chalovich

1247-Pos Board B315 S. AUREUS SPHINGOMYELINASE IS A STATE-DEPENDENT INHIBITOR OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR). Brandon Stauffer 1248-Pos Board B316 MECHANISM OF ACTION OF A SMALL MOLECULE ACTIVATOR OF PHOS- PHOINOSITIDE-DEPENDENT GIRK CHANNELS. Yu Xu , Takeharu Kawano, Junghoon Ha, Sumanta Garai, Guoqing Xiang, Ganesh Thakur, Diomedes E. Logothetis 1249-Pos Board B317 REGULATION OF A FUNGAL K 2P CHANNEL BY PROTEIN KINASES. Ryan Manville, Andrew Corran, Anthony Lewis 1250-Pos Board B318 SILVER AS A PROBE OF SELECTIVITY FILTER GATING IN TREK-1 K2P CHAN- NELS. Marcus Schewe , Thomas Baukrowitz 1251-Pos Board B319 THE ORIGIN OF COUPLED CHLORIDE AND PROTON TRANSPORT IN A CL - / H + ANTIPORTER. Sangyun Lee , Heather B. Mayes, Jessica M. J. Swanson, Gregory A. Voth 1252-Pos Board B320 PHYLOGENETIC AND SEQUENCE ANALYSIS OF THE FLUCS, A REMARK- ABLE FAMILY OF FLUORIDE CHANNELS. Christian B. Macdonald , Randy B. Stockbridge 1253-Pos Board B321 MG 2+ INHIBITS CARDIAC SR CALCIUM RELEASE AND HAS BIPHASIC EF- FECTS ON CALMODULIN BINDING TO RYR2. Xiaoqiong Dong , Ivanita Stefanon, Rogerio F. Ribeiro Jr., Mena Said, Robyn T. Rebbeck, Razvan L. Cornea, Donald M. Bers 1254-Pos Board B322 INTERACTIONS BETWEEN NEURONAL JUNCTOPHILINS AND VOLTAGE GATED ION CHANNELS. Stefano Perni , Kurt G. Beam 1255-Pos Board B323 VOLTAGE DEPENDENT INHIBITION OF CX46 HEMICHANNELS BY CAL- CIUM. Bernardo I. Pinto , Amaury Pupo, Isaac Garcia, Karel Mena-Ulecia, Agustin Martinez, Ramon Latorre, Carlos Gonzalez 1256-Pos Board B324 DISTRIBUTION OF PHOSPHORYLATED CONNEXIN 43 IN GAP JUNCTIONS: IMPLICATIONS FOR ENDOCYTOSIS. Rachel A. Margraf , Rachael M. Kells Andrews, Matthias M. Falk Cardiac Muscle Regulation I (Boards B325–B342) 1257-Pos Board B325 TUNING CARDIOMYOCITE DYNAMIC TRANSIENT RESPONSES WITH A HETEROGENEOUS POPULATIONS OF CTNC MUTATIONS. Srboljub Mijailovic, Djordje Nedic , Marina Svicevic, Boban Stojanovic, Michael A. Geeves, Michael Regnier 1258-Pos Board B326 DIFFERENTIAL CAMK-II ACTIVATION IN THE PROGRESSION OF HCM IN CTNT MUTATIONS. Sarah Lehman , Lauren Grinspan, Mark E. Anderson, Jil C. Tardiff 1259-Pos Board B327 CTNT ISOFORM SWITCHING IN THE DEVELOPMENT OF EARLY CHILD- HOOD TROPOMYOSIN-LINKED DCM. Melissa Lynn , Teryn Holeman, Lauren Grinspan, J.P. Jin, Jil Tardiff

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