Biophysical Society 62nd Annual Meeting | Program Guide

1862-Plat 11:00 am GGAMMA ASSISTS GBETA TO ACTIVATE GIRK1 BY RELAXING INHIBITORY CONSTRAINT.  Galit Tabak, Tal Keren Raifman, Vladimir Tsemakhovich, Nathan Dascal 1863-Plat 11:15 am CONTROL OF amPA RECEPTOR ACTIVITY BY THE EXTRACELLULAR LOOPS OF AUXILIARY PROTEINS.  Clarissa Eibl , Irene Riva, Rudolf Volkmer, Anna L. Carbone, Andrew J. R. Plested 1864-Plat 11:30 am PROTONATION STATE OF GLUTAMATE 73 REGULATES THE FORMATION OF A UNIQUE DIMERIC ASSOCIATION OF VDAC1.  Lucie A. Bergdoll , Michael T. Lerch, John W. Patrick, Christian Altenbach, Paola Bisignano, Arthur Laganowsky, Michael Grabe, Wayne Hubbell, Jeff Abramson 1865-Plat 11:45 am VOLTAGE-DEPENDENT CONFORMATIONAL CHANGES OF KV1.3 POTAS- SIUM CHANNELS ARE AN ESSENTIAL ELEMENT FOR KV1.3-INDUCED CELL PROLIFERATION. M. Teresa Pérez-García , Pilar Cidad, Esperanza Alonso, Pablo Fernández-Velasco, Miguel A. de la Fuente, José R. López-López 1866-Plat 12:00 pm ASSOCIATION OF HERG AND SCN5A TRANSCRIPTS REGULATES ION CHAN- NEL EXPRESSION AND FUNCTION IN STEM CELL DERIVED CARDIOMYO- CYTES.  Catherine A. Eichel , Erick Rios-Perez, Fang Liu, David K. Jones, Gail A. Robertson 1867-Plat 12:15 pm A HYPERPOLARIZATION-ACTIVATED PROTON CHANNEL IN ZEBRAFISH SPERM.  Reinhard Seifert , Lea Wobig, Therese Wolfenstetter, Sylvia Fechner, Wolfgang Bönigk, Heinz-Gerd Körschen, U. Benjamin Kaupp, Thomas Berger 1868-Plat 12:30 pm INSIGHTS ON GATING FUNCTIONS OF CYTOSOLIC DOMAINS OF CON- NEXIN26 HEMICHANNELS REVEALED BY A HUMAN PATHOGENIC MUTA- TION (N14K).  Juan M. Valdez Capuccino , Payal Chatterjee, Isaac Garcia, Andrew L. Harris, Yun Luo, Jorge E. Contreras Platform Membrane Structure 10:45 am–12:45 pm, South, Level Two, Room 215/216 Co-Chairs Svetlana Baoukina, University of Calgary, Canada Ilya Levental, University of Texas Medical School at Houston 1869-Plat 10:45 am LIPID ORGANIZATION IN SIMULATIONS OF CELL MEMBRANES.  Svetlana Baoukina , Helgi I. Ingolfsson, Siewert J. Marrink, D Peter Tieleman 1870-Plat 11:00 am CHOLESTEROL-INDUCED MEMBRANE ORGANIZATION PROMOTES INFLU- ENZA VIRUS BINDING.  Isabel Nadine Goronzy , Robert Rawle, Steven Boxer, Peter Kasson 1871-Plat 11:15 am NANOSCALE MEMBRANE CURVATURE GENERATED BY CHOLERA TOXIN SUBUNIT B: THE EFFECTS OF LIPID CROSS-LINKING AND LIPID PHASE.  Abir Maarouf Kabbani, Xinxin Woodward, Christopher V. Kelly 1872-Plat 11:30 am A STEP FORWARD IN THE DESIGN OF LIPOSOMES: SYMMETRIC & ASYM- METRIC VESICLES FROM LIPID EXTRACTS.  Laura Paulowski , Thomas Gutsmann, Tonio Kutscher 1873-Plat 11:45 am STRUCTURAL DETERMINANTS AND FUNCTIONAL CONSEQUENCES OF PROTEIN ASSOCIATION WITH MEMBRANE DOMAINS.  Joseph Lorent, Blanca Barbara Diaz-Rohrer, Xubo Lin, Alex Gorfe, Kandice R. Levental, Ilya Levental

8, 16 or 48 parallel patch clamp recordings in conjunction with computer controlled liquid handling, and on-board cell handling. Sophion part- ners with other biotech companies to create robust, ion channel, and electrophysiological workflows for drug development for ion channel targets. During this workshop, three industry speakers will provide insight into the drug discovery process. Dr. Damian Bell will present how Iontas uses Maxcyte’s scalable electroporation platform and QPatch to advance its antibody programs for ion channel targets. Dr. Daniel Sauter from Sophion Bioscience will present data from the development of protocols for using QPatch with pluripotent stem-cell derived cardiomyocytes from Ncardia (Cor4U). Finally, Dr. Alan Wickenden from Janssen Research and Development will present on Johnson and Johnson’s development of selective peptide, Nav1.7 inhibitor as a novel analgesic. Speakers Damian Bell, Head of Electrophysiology, Iontas Ltd Daniel Sauter, Application Scientist, Sophion Bioscience A/S Alan Wickenden, Scientific Director and Fellow, Molecular and Cellular Pharmacology, Janssen Research and Development LLC Symposium Awards 10:45 am–12:45 pm, North, Lower Lobby, Room 24 Chair Lukas Tamm, University of Virginia and BPS President No Abstract 10:45 am CFTR, THE ODD ABC TRANSPORTER RESPONSIBLE FOR CYSTIC FIBROSIS.  Jue Chen No Abstract 11:02 am QUANTITATIVE IN SITU IMAGING OF CELLULAR LIPID DYNAMICS.  Wonhwa Cho No Abstract 11:19 am DISSECTING THE MOLECULAR BASIS FOR CIRCADIAN TIMEKEEPING.  Carrie L. Partch No Abstract 11:36 am TOPOGRAPHIC CUES FOR MANIPULATING INTRACELLULAR SIGNALING AT NANOSCALE.  Bianxiao Cui No Abstract 11:53 am PHYSICS OF DNA AND CHROMATIN FUNCTION.  Taekjip Ha No Abstract 12:10 pm HYPERTROPHIC CARDIOMYOPATHY AND THEMYOSIN MESA: VIEWING AN OLD DISEASE IN A NEW LIGHT.  James Spudich No Abstract 12:27 pm MICROPARTICLE ASSEMBLY PATHWAYS ON LIPID MEMBRANES.  Daniela J. Kraft Platform Channel Regulation 10:45 am–12:45 pm, South, Level Two, Room 207/208 Co-Chairs Jorge Contreras, Rutgers University Teresa Pérez-García, University of Valladolid, Spain 1861-Plat 10:45 am CODON USAGE INFLUENCES GATING OF SMALL K + CHANNELS.  Kerri Kukovetz, Anja Engel, Sebastian Gutsfeld, Marina Kithil, Oliver Rauh, Anna Moroni, Gerhard Thiel

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