Biophysical Society 62nd Annual Meeting | Program Guide

1906-Plat 12:00 pm STRUCUTURAL BASIS OF REVERSIBLE amYLOID-LIKE INTERACTION IN MEDIATING HNRNP A1 PHASE SEPARATION.  Xinrui Gui , Feng Luo, Dan Li, Cong Liu 1907-Plat 12:15 pm CONFORMATIONAL DYNAMICS OF HUMAN PRION PROTEIN AND BIND- ING SITES OF ZN CATIONS. Maciej Gielnik, Michał Nowakowski, Michał Taube, Igor Zhukov, Wojciech M. Kwiatek, Dmitry M. Lesovoy, Maciej Kozak 1908-Plat 12:30 pm A WATER-SOLUBLE DSBB VARIANT THAT CATALYZES DISULFIDE-BOND FORMATION IN VIVO .  Dario Mizrachi , Matthew DeLisa Career Development Center Workshop Evaluating a Job Offer 11:30 am–12:30 pm, South, Lower Level, Room 2 So they’ve offered you the position and now you need to make a deci- sion. How you proceed from here on out is critical to ensure you start your new role in the organization successfully, and to ensure that you create a launchpad for future roles and compensation packages you will pursue. In this workshop, we will discuss how to evaluate the offer by examining a number of very specific elements of the opportunity, including what you will gain (for example, salary, skills, opportunity for advancement) and what you will give (for example, time for commuting and travel). We will work off of a checklist that you can use for any job of- fer you receive and even use it for scrutinizing multiple job offers at once. We will also discuss negotiation strategies and tactics. Exhibitor Presentation Malvern Panalytical 11:30 am–1:00 pm, Exhibit Hall, Room 5 Integration of Multiple Biophysical Tools to Accelerate the Biotherapeutic Development Process With the myriad of technologies available to assess the biophysical prop- erties of biological materials, it can sometimes be an overwhelming task to identify which properties are most important to assess. This workshop will provide a summary of a typical workflow that can be used to assess the stability indicating properties of biological drug products across three different development phases of a drug: Discovery Phase: From identification of lead candidates to early assess- ment of developability, the discovery phase is constantly expanding the properties that are being measured, while minimizing the volume of drug substance being used. Formulation Development: Identifying the right candidate in the right formulation is critical to a products success. The need to measure the most relevant properties of the formulation to identify manufacturability is the most important requirement. Manufacturing: Development of a robust manufacturing process, and early identification of issues associated with process change can keep you ahead of the curve to identify issues before they arise. Speakers Verna Frasca, Field Applications Manager, Biosciences, Malvern Panalytical Clayton Deighan, Field Applications Scientist, Biosciences, Malvern Panalytical Amber Fradkin, Director, Particle Characterization Core Facility, KBI Biopharma

1894-Plat 11:00 am VIDEO RATE ATOMIC FORCE MICROSCOPY OF BIOLOGICAL SAMPLES.  Sophia V. Hohlbauch 1895-Plat 11:15 am A SIMPLE AND FAST DRIFT CORRECTION METHOD FOR HIGH-THROUGH- PUT MICROSCOPY.  Arin Marchesi , Ignacio Casuso, Simon Scheuring, 11:30 am AN ELECTROMAGNETIC TWEEZERS FOR STUDYING FAST PROTEIN FOLD- ING DYNAMICS.  Rafael Tapia-Rojo , Jaime Andres RIvas-Pardo, Julio M. Fernandez 1897-Plat 11:45 am CPOW Travel Awardee DIRECT AND INDIRECT MAGNETIC FORCE MICROSCOPY IN HISTOLOGY.  Gunjan Agarwal , Brooke Ollander, Joshua Sifford, Kevin J. Walsh, Angela R. Blissett, Ping Wei, Dana M. McTigue 1898-Plat 12:00 pm LIVE CELL STED-AFM ANALYSIS CORRELATES CYTOSKELETAL STRUC- TURE REMODELLING AND MEMBRANE PHYSICAL PROPERTIES DURING POLARIZED MIGRATION IN ASTROCYTES.  Nathan Curry , Gregory Ghezali, Gabriele S. Kaminski Schierle, Nathalie Rouach, Clemens Kaminski 1899-Plat 12:15 pm MOVING BEYOND THE MECHANICAL CLAMP: AN EXPLORATION INTO DIFFERENTIAL MECHANICAL STABILITY OF UBIQUITIN FAMILY PROTEINS.  Mona Gupta , Ravindra Venkatramani, Sri Rama Koti Ainavarapu 1900-Plat 12:30 pm International Travel Awardee DECONSTRUCTING THE SINGLE MOLECULE MECHANICS OF AN ULTRAST- ABLE PATHOGEN ADHESIN.  Lukas F. Milles , Rafael C. Bernardi, Klaus Schulten, Hermann E. Gaub Platform Protein Structure and Conformation III 10:45 am–12:45 pm, Esplanade, Room 156 Co-Chairs Jakub Kubiak, Heinrich Heine Universität Düsseldorf, Germany Corie Ralston, Lawrence Berkeley National Laboratory 1901-Plat 10:45 am TIME-RESOLVED FLUORESCENCE SPECTROSCOPY CAPTURES EXCITED STATES OF A MEMBRANE ASSOCIATED PROTEIN.  Jakub Kubiak , Thomas Peulen, Claus A. M. Seidel 1902-Plat 11:00 am A GLIMPSE INTO THE SEQUENCE OF STRUCTURAL CHANGES IN THE ORANGE CAROTENOID PROTEIN WHICH SWITCH ON THE PHOTOPROTEC- TION MECHANISM IN CYANOBACTERIA.  Sayan Gupta, Maria A. Domin- guez-Martin, Han Bao, Markus Sutter, Jun Feng, Leanne-Jade G. Chan, Christopher J. Petzold, Cheryl A. Kerfeld, Corie Y. Ralston 1903-Plat 11:15 am REFINING PEPTIDE CONFORMATIONAL LANDSCAPE BY amIDE I INFRARED SPECTROSCOPY AND MD SIMULATIONS.  Chi-Jui Feng , Balamurugan Dhayalan, Xinxing Zhang, Andrei Tokmakoff 1904-Plat 11:30 am MAGNETIC ALIGNMENT OF A PROTEIN WITH TWO SPIN-LABELS: 1 + 1 ≠ 2?  James M. Gruschus , Madeleine Strickland, Marie-Paule Strub, Charles Schwieters, Nico Tjandra 1905-Plat 11:45 am Education Travel Awardee PROTEIN YOGA: CONFORMATIONAL FLEXIBILITY OF A NOVEL FOLD.  Anne R. Kaplan Felix Rico 1896-Plat

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