Biophysical Society 62nd Annual Meeting | Program Guide

2069-Pos Board B85 EFFECT OF THE FLEXIBLE REGIONS OF THE ONCOPROTEIN MOUSE DOUBLE MINUTE X ON INHIBITOR-BINDING AFFINITY. Xiyao Cheng , Jingjing Zhou, Yongqi Huang, Zhengding Su 2070-Pos Board B86 COMPARISON OF CALMODULIN LIGAND INTERACTIONS BY HIGH PRES- SURE X-RAY AND NEUTRON SCATTERING. Claus Czeslik , Roland Winter, Süleyman Cinar 2071-Pos Board B87 MONITORING PROTEIN-LIGANDS INTERACTIONS BY SINGLE-MOLECULE LYSOZYME NANOCIRCUITS.  James Froberg 2072-Pos Board B88 STRUCTURE-ACTIVITY RELATIONSHIP AND CHARACTERIZATION OF NOVEL INFLUENZA INHIBITORS. Gregory Mohl , Nathan Liddle, David Michaelis, David Busath 2073-Pos Board B89 REACTIVITY OF HEXACOORDINATED HEME PROTEINS ON ULTRAFAST TIMESCALES. Antonija Tangar , Shiori Yamazaki, Sophie Bernard, Valerie Derrien, Pierre Sebban, amy M. Scott, Jaroslava Miksovska 2074-Pos Board B90 DISTINCT MECHANISM OF OXYGEN AND CARBON MONOXIDE INTERAC- TIONS WITH HEME PROTEIN.  Jaroslava Miksovska , Ruipeng Lei, Sophie Bernad, Valerie Derrien Protein Dynamics and Allostery III (Boards B91–B106) 2075-Pos Board B91 ANALYZING ALLOSTERY WITH LONG-RANGE RIGIDITY PROPAGATION ACROSS PROTEIN NETWORKS. Adnan Sljoka 2076-Pos Board B92 USING CURRENT-FLOW SCHEME TO CAPTURE THE PROTEIN-PROTEIN BINDING ALLOSTERICITY. Yun Luo , Wesley M. Botello-Smith 2077-Pos Board B93 EVOLUTION OF CASPASE ALLOSTERY AND ENZYME SPECIFICITY. Clay Clark , Robert Grinshpon, Melvin E. Thomas, III, Liqi Yao, Suman Shrestha 2078-Pos Board B94 GETTING ALLOSTERIC CONTROL OVER PROTEIN ACTIVITY: NEW DEVEL- OPMENTS. Enrico Guarnera 2079-Pos Board B95 THEORETICAL ANALYSIS OF ALLOSTERIC AND OPERATOR BINDING FOR CYCLIC-AMP RECEPTOR PROTEIN MUTANTS. Tal Einav , Julia Duque, Rob Phillips 2080-Pos Board B96 THERMODYNAMIC COUPLING FUNCTION ANALYSIS OF ALLOSTERIC COUPLING BETWEEN NA + RELEASE AND INWARD-OPENING IN THE HU- MAN DOPAMINE TRANSPORTER. Michael V. LeVine , Michel A. Cuendet, Asghar M. Razavi, George Khelashvili, Harel Weinstein 2081-Pos Board B97 LEVERAGING COOPERATIVITY FOR POCKET DETECTION.  Justin R. Porter , Gregory R. Bowman, Katelyn E. Moeder 2082-Pos Board B98 THE RHEOSTATIC RESPONSE OF DYNAMIC ALLOSTERIC RESIDUE COUPLES (DARC) SPOT MUTATIONS. Paul Campitelli , Liskin Swint-Kruse, Banu Ozkan

2083-Pos Board B99 DYNAMIC COMMUNITIES IN PROTEINS: ALLOSTERIC HOTSPOTS AND FUNCTIONAL MODULES. Sambit Kumar Mishra , Gaurav Kandoi, Robert L. Jernigan 2084-Pos Board B100 TRANSIENT POCKET IDENTIFICATION AND EVALUATION OF THEIR ROLE FOR ALLOSTERY. Denis Schmidt , Christopher Pfleger, Susanne M.A. Hermans, Markus Boehm, Holger Gohlke 2085-Pos Board B101 WEAK DOMAIN STABILITY AND HIGHER CA 2+ BINDING AFFINITY CONTRIB- UTE TO ALLOSTERY BETWEEN THE D/E LINKER AND N-HELIX OF CARDIAC TROPONIN C. Mayra A. Marques , Adolfo H. Moraes, Jerson L. Silva, José R. Pinto, Guilherme A. P. de Oliveira 2086-Pos Board B102 ROLE OF LYS RESIDUE AT POSITION 87 OF DREAM IN ALLOSTERIC REGU- LATION OF DREAM’S INTERACTIONS WITH K V CHANNEL. Samiol Azam , Jaroslava Miksovska 2087-Pos Board B103 Education Travel Awardee CLASSIFICATION OF ALLOSTERY IN PROTEINS: A DEEP LEARNING AP- PROACH. Girik Malik , Andrzej Kloczkowski 2088-Pos Board B104 AN ALLOSTERIC MECHANISM OF ABL KINASE ACTIVATION AND CATALY- SIS. Tamjeed Saleh 2089-Pos Board B105 ALLOSTERY IN NMDA RECEPTORS. Ryan Durham , Drew Dolino, Vasanthi Jayaraman 2090-Pos Board B106 ALLOSTERY ADVOCATES IN MONOCLONAL ANTIBODY ENGINEERING TO- WARDS ANTIGEN BINDING. Chinh Su Membrane Protein Structures II (Boards B107–B127) 2091-Pos Board B107 International Travel Awardee SPECIFIC INTERACTIONS OF PROTEIN-PROTEIN INTERACTION BETWEEN HU- MAN PROGRAMMED DEATH 1 (PD-1) AND ITS LIGAND 1 (PD-L1) WITH AB INITIO FRAGMENT MOLECULAR ORBITAL METHOD. Ho Cheol Lim, Jung Ho Chun , Sung Bo Hwang, Jong Wan Kim, Kyoung Tae No 2092-Pos Board B108 INTERACTION BETWEEN A-SYNUCLEIN AND VAMP2 PROMOTES SNARE- EPENDENT VESICLE DOCKING AND FUSION. Brenden Hawk , Ryan Khounlo, Yeon-Kyun Shin, Julien Roche 2093-Pos Board B109 PROBING PLEXIN A3 DIMERIZATION AND THE IMPORTANCE OF THE NEAR MEMBRANE EXTRACELLULAR RESIDUES. Pouyan Khakbaz, Jeffery B. Klauda 2094-Pos Board B110 THE STRUCTURE OF KRAS4B-FME AT THE LIPID MEMBRANE. Frank Hein- rich , Que Van, Mathias Lösche, Andrew Stephen 2095-Pos Board B111 HIGH RESOLUTION CRYOEM STRUCTURE OF A MYCOBACTERIAL GLYCOS- YLTRANSFERASE. Yong Zi Tan , José Rodrigues, Oliver B. Clarke, Clinton S. Potter, Bridget Carragher, Margarida Archer, Filippo Mancia 2096-Pos Board B112 MECHANISM OF CATALYSIS AND INHIBITION IN DGAT1. Lie Wang , Yin Nian, Ming Zhou

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