Biophysical Society 62nd Annual Meeting | Program Guide

2140-Pos Board B156 COMBINING PREDICTION OF PROTEIN AGGREGATION PROPENSITIES WITH PREDICTION OF OTHER ONE-DIMENSIONAL PROPERTIES. Andrzej Kloczkowski , Maksim Kouza, Girik Malik, Irina Buhimschi, Eshel Faraggi 2141-Pos Board B157 IMPROVED ACCURACY AND CONVERGENCE OF INTRINSICALLY DISOR- DERED PROTEIN MOLECULAR DYNAMICS SIMULATIONS USING THE FF14IDPSFF FORCE FIELD. Vy T. Duong , Mahendra Thapa, Ray Luo RNA Structure and Dynamics (Boards B158–B187) 2142-Pos Board B158 IN VITRO APTAMER SELECTION AND EVOLUTION USING AN ENGINEERED DUAL-RIBOZYME COMPLEX. Michael Muntifering , David Wendell 2143-Pos Board B159 IDENTIFICATION OF AN ALLOSTERIC TWISTER RIBOZYME FOR USE AS A SYNTHETIC GENETIC SWITCH. Samantha M. Stoupa , Juliane Strauss- Soukup 2144-Pos Board B160 UNDERSTANDING AN RNA HELIX-JUNCTION-HELIX CONSTRUCT BY SAXS REFINEMENT OF MD MODELS. Yen-Lin Chen , Tongsik Lee, Lois Pollack, Ron Elber 2145-Pos Board B161 TIME-RESOLVED SAXS AND ENSEMBLE MODELLING REVEAL MAGNESIUM ORCHESTRATION ACROSS AN RNA FOLDING LANDSCAPE. Alex Plumridge , Andrea M. Katz, George D. Calvey, Ron Elber, Serdal Kirmizialtin, Lois Pol- lack 2146-Pos Board B162 MOLECULAR DYNAMICS SIMULATIONS OF A RIBOSWITCH BINDING amINOGLYCOSIDE ANTIBIOTICS. Marta Kulik , Takaharu Mori, Yuji Sugita, Joanna Trylska 2147-Pos Board B163 MIMICKING CO-TRANSCRIPTIONAL RNA FOLDING USING A SUPERHELI- CASE. Boyang Hua , Subrata Panja, Sarah Woodson, Taekjip Ha 2148-Pos Board B164 HIGH TEMPORAL- AND SPATIAL-RESOLUTION STUDIES OF A HELIX-TO- COIL TRANSITION THAT CONTROLS THE SWITCHING MECHANISM OF A RIBOSWITCH.  Jason Hon , Nathan S. Daly, Scott M. Trocchia, Colin Nuckolls, Kenneth L. Shepard, Ruben L. Gonzalez, Jr. 2149-Pos Board B165 KINETIC INVESTIGATION OF NATURAL PRODUCTS AND EXTRACTS FOR POTENTIAL RIBOSWITCH LIGANDS. Heidi Klem , Juliane Strauss-Soukup 2150-Pos Board B166 MICROSECOND CONFORMATIONAL DYNAMICS AND DISTINCT FOLDING MECHANISMS OF PREQ 1 RIBOSWITCH STUDIED BY TWO-DIMENSIONAL FLUORESCENCE LIFETIME CORRELATION SPECTROSCOPY. Bidyut Sarkar , Kunihiko Ishii, Tahei Tahara 2151-Pos Board B167 ANALYZING THE MONOMERIC CONFORMATION OF THE HIV-1 5 PRIME- LEADER RNA USING NUCLEAR MAGNETIC RESONANCE SPECTROSCO- PY. Matthew R. Orellana , Joshua Brown, Michael F. Summers 2152-Pos Board B168 DETERMINING THE STRUCTURE OF THE HIV-1 5 PRIME LEADER DIMERIC CONFORMATION. Tatiana Rodriguez , Joshua Brown, Michael Summers 2153-Pos Board B169 RNA END FLUCTUATIONS OUT OF A VIRUS: A PARASITE’S FISHING ROD FOR MAXIMIZING amPLIFICATION. Richard Sportsman , Liya Oster, Benjamin Kartub, Charles M. Knobler, WilliamM. Gelbart

2126-Pos Board B142 FIBRILLATION OF N-TERMINAL PRION PROTEIN FRAGMENT IN PRESENCE OF ZINC IONS. Maciej B. Gielnik , Michał Nowakowski, Aneta Szymańska, Igor Yu Zhukov, Wojciech Maria Kwiatek, Maciej Leszek Kozak 2127-Pos Board B143 POLYMORPHISM OF PRION PROTEIN amYLOID-LIKE FIBRILS.  Tomas Šneideris , Elžbieta Kulicka, Vytautas Smirnovas 2128-Pos Board B144 AMYLOID-Β PEPTIDE INTERACTION WITH LIPID BILAYER PROMOTES PEPTIDE AGGREGATION ON THE SURFACE AND MODULATES LIPID BEHAVIOR.  Jacob Usadi , Arthur Vale, Sashin Natesh, Karl Freed, Esmael Haddadian 2129-Pos Board B145 MODULATING amYLOID-BETA AGGREGATION TO REDUCE THE TOXICITY OF ITS OLIGOMERIC AGGREGATES. Ryan Limbocker , Benedetta Man- nini, Sean Chia, Francesco S. Ruggeri, Michele Perni, Roberta Cascella, Catherine Xu, Johnny Habchi, Janet R. Kumita, Fabrizio Chiti, Tuomas P. J. Knowles, Michele Vendruscolo, Christopher M. Dobson 2130-Pos Board B146 PROBING SYNAPTIC amYLOID-BETA AGGREGATION PROMOTED BY COP- PER RELEASE. Bogachan Tahirbegi, Alastair J. Magness, Aurelien Boillat, Keith R. Willison, David R. Klug, Thomas Knopfel, Liming Ying 2131-Pos Board B147 GAS PHASE STUDIES OF THE amYLOID-Β PEPTIDE. Nicklas Österlund , Sebastian K.T.S Wärmländer, Leopold L. Ilag, Astrid Gräslund 2132-Pos Board B148 QUANTITATIVE HYDROXYL RADICAL FOOTPRINTING STUDY REVEALS STRUCTURAL DETAILS OF THE DISORDER-TO-ORDER TRANSITION IN amYLOID-BETA (1-42) OLIGOMERIZATION. Janna Kiselar, Andrew Nix, An- ant Paravastu, Terrone Rosenberry, Alexandra Klinger 2133-Pos Board B149 A MULTI-SCALE STUDY OF Β-AMYLOID WILD-TYPE AND MUTANT PEP- TIDES: MONOMERS, OLIGOMERS, FIBRILS. Arthur O. Vale , Jacob Usadi, Sachin R. Natesh, Sarida Pratuangtham, Karl F. Freed, Esmael J. Haddadian 2134-Pos Board B150 THE FUNCTIONAL amYLOID ORB2A INTERACTS WITH LIPID BILAYERS. Maria A. Soria , Silvia A. Cervantes, Thalia H. Bajakian, Ansgar B. Siemer 2135-Pos Board B151 FIBRILLATION OF A-BETA PEPTIDES IN PRESENCE OF PHENOLIC INHIBI- TORS: COARSE-GRAINED SIMULATIONS. Carol K. Hall , Yiming Wang 2136-Pos Board B152 ATOMIC-LEVEL INSIGHTS INTO THE DYNAMICS OF ENZYMES AND INTRINSICALLY DISORDERED PROTEINS WITHIN SEA SPRAY AEROSOL PARTICLES.  Jamie Schiffer , Rommie amaro 2137-Pos Board B153 MODELING INTRINSICALLY DISORDERED PROTEINS AND amYLOID FIBRILS IN PYROSETTA.  John Ferrie , Abhinav Nath, E. James Petersson 2138-Pos Board B154 COARSE-GRAINED SIMULATIONS OF INTRINSICALLY DISORDERED PRO- TEINS IN THE CONTEXT OF LIQUID-LIQUID PHASE SEPARATION. Gregory L. Dignon , Wenwei Zheng, Young C. Kim, Jeetain Mittal, Robert Best 2139-Pos Board B155 INCREASING THE ACCURACY IN ALL-ATOM SIMULATIONS OF INTRINSI- CALLY DISORDERED PROTEINS BASED ON THE ABSINTH MODEL. Martin J. Fossat , Tyler S. Harmon, ammon E. Posey, Jeong-Mo Choi, Rohit V. Pappu

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