Biophysical Society 62nd Annual Meeting | Program Guide

2848-Pos Board B56 ITERATIVE MOLECULAR DYNAMICS−ROSETTA MEMBRANE PROTEIN STRUCTURE REFINEMENT GUIDED BY CRYO-EM DENSITIES. Sumudu Leelananda, Steffen Lindert 2849-Pos Board B57 COMPUTATIONAL DESIGN OF HIGH-RESOLUTION PROTEIN CRYSTALS.  Jeliazko R. Jeliazkov , Aaron C. Robinson, James M. Berger, Bertrand García-Moreno E., Jeffrey J. Gray 2850-Pos Board B58 RELATIVE CONTRIBUTION OF THE REFINEMENT STEPS TO THE PROTEIN- PROTEIN DOCKING SUCCESS RATE. Taras Dauzhenka , Ivan Anishchenko, Petras J. Kundrotas, Ilya A. Vakser 2851-Pos Board B59 STRUCTURE MODELING OF DISORDERED PROTEIN INTERACTIONS. Lenna X. Peterson, amitava Roy, Charles Christoffer, Genki Terashi, Daisuke Kihara 2852-Pos Board B60 A NOVEL SET OF QUANTITATIVE RULES FOR BIOLOGICAL OR BIOCHEMI- CAL SELF-ASSEMBLY IN WATER. Xian Cheng , Irina Shkel 2853-Pos Board B61 COMPARISON OF FULL AND INTERFACE STRUCTURE ALIGNMENT IN TEMPLATE-BASED PROTEIN DOCKING. Devlina Chakravarty 2854-Pos Board B62 PREDICTING THE EFFECT OF MUTATIONS IN THE KRAS/C-RAF-RBD PRO- TEIN-PROTEIN INTERFACE. Anna Lowegard , Marcel Frenkel, Bruce Donald 2855-Pos Board B63 SMALL ANGLE X-RAY SCATTERING FOR DATA-ASSISTED STRUCTURE PRE- DICTION IN CASP12 WITH PROSPECTS TO IMPROVE ACCURACY. Tadeusz L. Ogorzalek, Greg L. Hura, Andriy Kryshtafovych, John A. Tainer, Krzysztof Fidelis, Susan E. Tsutakawa 2856-Pos Board B64 Education Travel Awardee MIMICKING MICROBIAL RHODOPSIN ISOMERIZATION. Alireza Ghanbarpour , Muath Nairat, Meisam Nosrati, Elizabeth Santos, Chrys- oula Vasileiou, Babak Borhan, James Geiger Protein Stability, Folding, and Chaperones III (Boards B65–B92) 2857-Pos Board B65 STRUCTURAL-ELASTIC DETERMINATION OF THE LIFETIME OF BIOMOL- ECULES UNDER FORCE. Shiwen Guo, Jie Yan 2858-Pos Board B66 EQUILIBRIUM AND NON-EQUILIBRIUM STUDIES OF PROTEIN G USING HIGH-RESOLUTION OPTICAL TRAPPING UNVEIL HETEROGENEOUS UN- FOLDING PATHWAYS. Yujie Chen , Dena Izadi, Miles L. Whitmore, Joseph D. Slivka, Lisa J. Lapidus, Matthew J. Comstock 2859-Pos Board B67 MECHANICAL UNFOLDING AND FOLDING OF A SLIPKNOT PROTEIN OBSERVED BY USING OPTICAL TWEEZERS. Han Wang , Chengzhi He, Chunguang Hu, Hongbin Li 2860-Pos Board B68 AN EVOLUTIONARY TREND TOWARDS KINETIC STABILITY IN THE FOLDING TRAJECTORY OF RIBONUCLEASES H. Shion A. Lim , Eric R. Bolin, Kathryn M. Hart, Michael J. Harms, Susan Marqusee 2861-Pos Board B69 SINGLE-MOLECULE ASSAY FOR PROTEOLYTIC SUSCEPTIBILITY: FORCE- INDUCED DESTABILIZATION OF COLLAGEN’S TRIPLE HELIX. Michael W.H. Kirkness, Nancy R. Forde

2862-Pos Board B70 COMPARISON OF THE STABILITY AND REDUCTION POTENTIAL OF CYTO- CHROME C 6 PROTEINS FROM A PSYCHROPHILIC AND A MESOPHILIC DIA- TOM. Logan Tillery, Miranda Wilson , Nayandeep Parmar, Katherine Frato 2863-Pos Board B71 PARAMETER OPTIMIZATION FOR A NEW REACTION PATHWAY SAMPLING METHOD: ACTION-CSA. Naohiro Nishikawa , Juyong Lee, Bernard R. Brooks 2864-Pos Board B72 EXAMINATION OF THE EFFECT OF A HISTIDINE TAG ON THE ENERGY LANDSCAPE OF ACBP.  Jamie Stankiewiz 2865-Pos Board B73 KNOB-SOCKET PREDICTIONS OF ALPHA-HELICAL STABILITY. Taylor R. Rabara , Joshman Singh, Danielle MacArt, Shivarni Patel, Hyun Joo, Jerry Tsai 2866-Pos Board B74 HIGH HYDROSTATIC PRESSURE (HHP), XENON AS A PROBE AND SPIN LABELLING OF THE N-TERMINAL DOMAIN REVEAL A WHOLE VARIETY OF CONFORMATIONAL TRANSITIONS IN THE FULL-LENGTH HUMAN PRION PROTEIN. Werner Kremer 2867-Pos Board B75 EXPLORING AND ENHANCING COMPARTMENT-SPECIFIC PROTEIN DISAG- GREGASES TO COMBAT NEURODEGENERATIVE DISEASES. Ryan R. Cupo , Emily Augustine, James Shorter 2868-Pos Board B76 DISULFIDE TRANSFER ENABLES INVERSE-PRION AGGREGATION IN MIX- TURES OF HUMAN GAMMA-D CRYSTALLIN VARIANTS. Eugene Serebryany , Jimmy Thai, Jaie C. Woodard, Shuhuai Yu, Sunia A. Trauger, Bogdan Budnik, Eugene I. Shakhnovich 2869-Pos Board B77 INVESTIGATING THE EFFECT OF CANCER-RELATED MUTATIONS ON THE STRUCTURE AND FUNCTION OF INTEGRIN ΑVΒ3 HETERODIMERS THROUGH MOLECULAR DYNAMICS SIMULATIONS. Rey Kristoffer V. Sali- nas , Raphael D. Caballes, Andre Rhey C. Haro, Neil Andrew D. Bascos 2870-Pos Board B78 SEQUENTIAL FOLDING OF GLOBULAR PROTEIN INITIATED BY FAST LOOP CLOSURE. Elisha Haas , Gil Rahamim, Dan amir 2871-Pos Board B79 CID Travel Awardee A RIGHT-HANDED COILED COIL TETRAMER TO INDUCE CELL ARREST IN PROSTATIC CARCINOMA CELLS. Francisco Padron , JingJing Li, Rihe Liu 2872-Pos Board B80 EGCG INHIBITS FIBRILLATION OF LIGHT CHAIN 6AJL2-R24G, ASSOCIATED WITH LIGHT CHAIN amYLOIDOSIS. Angel Enrique Peláez–Aguilar , Lina Andrea Rivillas Acevedo, Leidys French Pacheco, Gilberto Valdes García, Roberto Maya Martínez, Nina Pastor Colón, Carlos amero Tello 2873-Pos Board B81 A HELIX 1 PEPTIDE FROM UBA(1) PROVIDES EVIDENCE FOR TERTIARY INTERACTIONS IN THE DENATURED STATE OF UBA(1). Dustin C. Becht , Bruce E. Bowler 2874-Pos Board B82 PRIMARY AND SECONDARY STRUCTURE PREFERENCE OF HYDROGEN EXCHANGE. Boshen Wang , Jie Liang 2875-Pos Board B83 USING ANCESTRAL PROTEINS TO PROBE THE THERMODYNAMIC AND KINETIC PROPERTIES OF THE ALPHA-LYTIC PROTEASE FAMILY. Charlotte Nixon , Shion A. Lim, Zachary Sailer, Michael Harms, Susan Marqusee

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