Biophysical Society 62nd Annual Meeting | Program Guide

3079-Pos Board B287 SUPER RESOLUTION IMAGING OF RYANODINE RECEPTOR CLUSTER MORPHOLOGY IN RABBIT AND HUMAN ATRIAL MYOCYTES. Daria Boyd , Antony Workman, Niall Macquaide 3080-Pos Board B288 ASSOCIATION OF CARDIAC MYOSIN BINDING PROTEIN-C WITH THE RYANODINE RECEPTOR-CA 2+ RELEASE CHANNEL: PUTATIVE RETROGRADE REGULATION? Paulina Stanczyk, Monika Seidel, Judith White, Cedric Viero, Chris George, Spyros Zissimopoulos, F. Anthony Lai 3081-Pos Board B289 TRAFFICKING OF PHOSPHOLAMBAN AND SERCA2A FOLLOWS THE NUCLEAR ENVELOPE-TO-SR ALONG T-TUBULES (NEST) PATHWAY COM- MON TO JUNCTIONAL SARCOPLASMIC RETICULUM (SR) PROTEINS. Dan- ning Wang, Juyi Wan, Steven E. Cala, Zhenhui Chen 3082-Pos Board B290 STATINS BIND TO CARDIAC RYANODINE RECEPTOR (RYR2) CHANNELS TO ALTER OPENING FREQUENCY. Abigail D. Wilson , Chris Lindsay, Elisa Venturi, Angela J. Russell, Rebecca Sitsapesan 3083-Pos Board B291 PHOSPHORYLATION OF THE TYPE 2 RYANODINE RECEPTORS PLAYS A ROLE IN THE ORGANIZATION OF THEIR ARRAY. Parisa Asghari , David R.L. Scriven, Hector Valdivia, Xander Wehrens, Edwin D.W. Moore 3084-Pos Board B292 BINDING AND REGULATION OF THE CARDIAC RYANODINE RECEPTOR BY PKA AND CAMKII. Omid Haji-Ghassemi 3085-Pos Board B293 MOLECULAR BASIS FOR CA 2+ BINDING OF RYR2 FOR CHANNEL ACTIVA- TION AND DISEASES STATES. Takashi Murayama , Haruo Ogawa, Nagomi Kurebayashi, Takashi Sakurai Cardiac, Smooth and Skeletal Muscle Electrophysiology II (Boards B294–B316) 3086-Pos Board B294 SELF-ORGANIZATION OF FUNCTIONAL COUPLING BETWEEN MEMBRANE AND CALCIUM CLOCK IN ARRESTED HUMAN SINOATRIAL NODAL CELLS IN RESPONSE TO CAMP. Kenta Tsutsui , Oliver Monfredi, Syevda Sirenko, Rostialav Bychkov, Larissa A. Maltseva, Mary S. Kim, Bruce D. Ziman, Kirill V. Tarasov, Mingyi Wang, Alexander V. Maltsev, Jaclyn A. Brennan, Igor R. Efimov, Michael D. Stern, Victor A. Maltsev, Edward G. Lakatta 3087-Pos Board B295 POSITIVE FEEDBACK MECHANISMS amONG LOCAL CA RELEASES, NCX, & I CAL IGNITE PACEMAKER ACTION POTENTIALS. Victor A. Maltsev , Alexey E. Lyashkov, Joachim Behar, Edward G. Lakatta, Yael Yaniv 3088-Pos Board B296 COMBINED EFFECTS OF GAP JUNCTIONAL AND EPHAPTIC COUPLING THERAPIES ON CONDUCTION AND ARRHYTHMOGENESIS DURING ISCHEMIA/REPERFUSION. Gregory S. Hoeker , Carissa C. James, Sarah H. Barrett, James W. Smyth, Steven Poelzing 3089-Pos Board B297 SAP97 EXPRESSION IS IMPORTANT FOR HEART RATE CONTROL IN THE MURINE SINUS NODE. Todd Herron, Brad Rosinski, Roberto Ramos Mon- dragon, Hassan Musa, Kamel Aoun, Lakshmi Mundada, Steven Whitesall, Yan Chen, Nulang Wang, Guadalupe Guerrero-Serna, Hector Valdivia, Justus M. Anumonwo 3090-Pos Board B298 Education Travel Awardee L-TYPE CALCIUM CHANNEL GATING MODIFIERS AS A NEW CLASS OF ANTIARRHYTHMIC DRUGS. Marina Angelini , Arash Pezhouman, Marvin G. Chang, Nicoletta Savalli, Guillaume Calmettes, Antonios Pantazis, Hrayr S. Karagueuzian, James N. Weiss, Riccardo Olcese

3066-Pos Board B274 ROLE OF EPAC2 IN HIGH GLUCOSE-INDUCED SR CA 2+ LEAK AND ARRHYTH- MIA. Magali Samia el Hayek, Donald Bers, Ana-Maria Gomez, Laetitia Pereira 3067-Pos Board B275 INTERPLAY BETWEEN TRIADIN AND CALSEQUESTRIN IN THE PATHOGEN- ESIS OF CVPT. Marine Cacheux, Jérôme Thireau, Jérémy Fauconnier, Alexis Osseni, Nathalie Roux-Buisson, Julie Brocard, Julien Fauré, Alain Lacam- pagne, Isabelle Marty 3068-Pos Board B276 T-TUBULE LOSS IS A PROMINENT FEATURE OF HFREF BUT NOT HFPEF. Mi- chael Frisk, Michael Frisk , Christopher Le, Christen P. Dahl, Ida G. Lunde, Vibeke M. Almaas, Lars Gullestad, Svend Aakhus, Ole M. Sejersted, Theis Tønnessen, William E. Louch 3069-Pos Board B277 CHOLESTEROL PROTECTS AGAINST ACUTE STRESS-INDUCED T-TUBULE REMODELING IN MOUSE VENTRICULAR MYOCYTES. Azadeh Nikouee, Keita Uchida, Anatoli N. Lopatin 3070-Pos Board B278 T-TUBULAR CONSTRICTIONS PROMOTE T-TUBULE SEALING. Keita Uchida , Azadeh Nikouee, Greta Tamkus, Anatoli N. Lopatin 3071-Pos Board B279 THE ROLE OF NCX1 ON THE MAINTENANCE OF T-TUBULE ARCHITECTURE IN PRESSURE-OVERLOADED HEARTS. Yoshihiro Ujihara , Satomi Takatsu, Keiji Naruse, Satoshi Mohri, Yuki Katanosaka 3072-Pos Board B280 RECOVERY OF CARDIAC T-TUBULES AFTER HYPOSMOTIC SHOCK. Greta Tamkus , Keita Uchida, Anatoli N. Lopatin 3073-Pos Board B281 COMPARABLE CALCIUM HANDLING AND CONTRACTILITY IN HUMAN IPSC CARDIOMYOCYTE MODELS OF THREE DIFFERENT HYPERTROPHIC CARDIOMYOPATHY-LINKED MUTATIONS. Kyungsoo Kim , Lili Wang, Vasco Sequeira, Joseph C. Wu, Bjorn C. Knollmann 3074-Pos Board B282 MECHANOTRANSDUCTION VIA NO SIGNALING AUTO-REGULATES CAR- DIOMYOCYTE CONTRACTILITY. Rafael Shimkunas , Bence Hegyi, Zhong Jian, Zana Coulibaly, John A. Shaw, Nipavan Chiamvimonvat, Kit S. Lam, Leighton Izu, Ye Chen-Izu 3075-Pos Board B283 VISCOELASTIC ESHELBY ANALYSIS OF THE CELL-IN-GELL SYSTEM.  John Shaw 3076-Pos Board B284 MECHANICAL LOAD EFFECTS ON CARDIOMYOCYTE ACTION POTENTIAL, CACIUM TRANSIENT, AND CONTRACTION REVEALED BY USING A NOVEL PATCH-CLAMP-IN-GEL TECHNOLOGY. Zhong Jian , Yi-je Chen, Bence Hegyi, Tamas Banyasz, Zana Coulibaly, Rafael Shimkunas, Nipavan Chiamvimon- vat, Kit S. Lam, Leighton T. Izu, Ye Chen-Izu 3077-Pos Board B285 Education Travel Awardee SUPERRESOLUTION (DSTORM) IMAGING OF CALCIUM HANDLING PRO- TEINS IN CARDIOMYOCYTES. Ornella Manfra , Xin Shen, Johannes W. Hell, William Edward Louch 3078-Pos Board B286 3D DSTORM IMAGING REVEALS DISASSEMBLY OF RYANODINE RECEP- TOR CLUSTERS IN FAILING CARDIOMYOCYTES. Xin Shen , Jonas van den Brink, Terje R. Kolstad, Einar Norden, Andy G. Edwards, Michael Frisk, Ivar Sjaastad, Christian Soeller, William E. Louch

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