Biophysical Society 62nd Annual Meeting | Program Guide

3129-Pos Board B337 ENHANCED TETRODOTOXIN-SENSITIVE NEURONAL NA + CHANNEL ACTIV- ITY ASSOCIATED WITH ARRHYTHMOGENIC CALMODULIN MUTATION N98S. Przemyslaw Radwanski , Jonathan Davis, Sandor Gyorke 3130-Pos Board B338 CHARACTERIZATION OF A NAV1.4 HYPOKALEMIC PERIODIC PARALYSIS MUTATION IN DOMAIN I.  James R. Groome , Landon Bayless-Edwards, Paula Arinze, Frank Lehmann-Horn, Karin Jurkat-Rott 3131-Pos Board B339 BIOPHYSICAL CHARACTERIZATION OF TWO NAV1.4 MUTATIONS MAKING A CLINICAL OVERLAP BETWEEN THE MYOTONIA-HYPERKALEMIC AND HYPOKALEMIC PERIODIC PARALYSIS CLUSTERS OF DISORDERS. Mohamed Chahine , Hugo Poulin, Pascal Gosselin-Badaroudine, Savine Vicart, Karima Habbout, Damien Sternberg, Serena Giuliano, Bertrand Fontaine, Saïd Bendahhou, Sophie Nicole 3132-Pos Board B340 PHYSIOLOGICAL TRADEOFFS OF TTX RESISTANCE IN NA V 1.4: WHOLE CELL ELECTROPHYSIOLOGY AND TISSUE MYOGRAPHY REVEAL REDUCED TETRODOTOXICITY AT THE COST OF CHANNEL FUNCTION. Robert E. del Carlo , Jessica S. Reimche, Michael T.J. Hague, Edmund D. Brodie, Jr., Normand Leblanc, Chris R. Feldman 3133-Pos Board B341 Education Travel Awardee INVESTIGATING A DOMAIN I HYPOKALEMIC PERIODIC PARALYSIS MUTA- TION IN HNAV1.4: A COMPUTATIONAL APPROACH. Landon J. Bayless- Edwards , James R. Groome, Frank Lehmann-Horn, Vern Winston, Karin Jurkat-Rott 3134-Pos Board B342 NAV1.4 LOSS OF FUNCTION CHANGES FOR RECESSIVELY INHERITED MYOPATHY WITH FLUCTUATING WEAKNESS. Nathaniel Elia , Perry Shieh, Marbella Quinonez, Stephen Cannon 3135-Pos Board B343 A COMPUTATIONAL MODEL OF THE CARDIAC SODIUM CHANNEL DIII VOLTAGE SENSOR: CONNECTING MOLECULAR MOVEMENTS TO TISSUE DYNAMICS.  Jonathan Moreno , Wandi Zhu, Jonathan Silva 3136-Pos Board B344 INTRACELLULAR CALCIUM ALTERS SODIUM CHANNEL KINETICS TO INFLUENCE NEURONAL FIRING. Marco A. Navarro , Jenna L. Lin, Benton R. Berigan, Mirela Milescu, Lorin S. Milescu 3137-Pos Board B345 SYNTHETIC BATRACHOTOXIN DERIVATIVES AS MOLECULAR PROBES OF VOLTAGE-GATED SODIUM ION CHANNEL FUNCTION. Timothy M.G. MacKenzie , Justin Du Bois 3138-Pos Board B346 RECOMBINANT EXPRESSION OF A VOLTAGE SENSING DOMAIN FROM HU- MAN NAV1.7. Ryan V. Schroder , Ping Wang, Sebastien F. Poget 3139-Pos Board B347 SEQUENCE AND 3D ALIGNMENTS OF THE PORE-LINING HELICES IN P-LOOP CHANNELS REVEAL THEIR CONSERVED AND VARIABLE FEA- TURES. Denis B. Tikhonov, Boris S. Zhorov 3140-Pos Board B348 MECHANISM OF SELECTIVE RESISTANCE OF THE BUMBLE BEE SODIUM CHANNEL BINA V 1 TO TAU-FLUVALINATE. Ke Dong , Shaoying Wu, Yoshiko Nomura, Yuzhe Du, Boris Zhorov 3141-Pos Board B349 SELECTIVE CONDUCTION IN A HUMAN SODIUM CHANNEL CONTROLLED BY ION-CARBOXYLATE AND LYSINE INTERACTIONS. Emelie Flood, Céline Boiteux, Toby W. Allen

3116-Pos Board B324 HYDROPHOBIC-MEDIATED ASSEMBLY OF LIPID-COATED BUILDING BLOCKS BY DOUBLE-END ANCHORED POLYMERS. Emily Wonder , Chenyu Liu, Kai K. Ewert, Phillip Kohl, Youli Li, Weihong Qiao, Cyrus R. Safinya 3117-Pos Board B325 OPTIMIZING CATIONIC LIPOSOME COMPOSITION FOR HYDROPHOBIC DRUG LOADING AND DELIVERY TO HUMAN CANCER CELLS. Victoria Steffes , Scott MacDonald, Meena M. Murali, Kai K. Ewert, Cyrus R. Safinya 3118-Pos Board B326 ACTIN CORRALS G-PROTEIN COUPLED RECEPTORS IN CILIARY MEM- BRANE. Sungsu Lee , Peter Calvert 3119-Pos Board B327 RETROGRADE DIFFUSION OF KINESIN-II FACILITATES FLAGELLAR LENGTH CONTROL IN CHLAMYDOMONAS. . Alexander Chien , Sheng Ming Shih, Raqual Bower, Douglas Tritschler, Mary E. Porter, Ahmet Yildiz 3120-Pos Board B328 REGULATION OF RAB5 IN ITS EFFECTOR BINDING AND GUANINE NUCLEO- TIDE CONVERSION BY SITE-SPECIFIC MONOUBIQUITINATION. Sangho Lee 3121-Pos Board B329 RESOLVING ENDOSOME ROTATION IN INTRACELLULAR TRAFFICKING. Yan Yu 3122-Pos Board B330 KINETIC MODELING OF WEAK BASE NACHR LIGAND SELECTIVE TRAPPING WITHIN INTRACELLULAR ACIDIC VESICLES: INSIGHTS INTO MECHANISMS UNDERLYING NICOTINE ADDICTION AND SMOKING CESSATION. Yuqi Liu , Stefan Trapp, William N. Green, Esmael J. Haddadian 3123-Pos Board B331 INTRACELLULAR TRANSPORT CHARACTERIZATION OF THE TRANSCRIP- TION FACTOR GLI2 BY FLUORESCENCE CORRELATION SPECTROSCOPY AP- PROACHES. Belén Torrado , Leonel Malacrida, José Luis Badano, Florencia Irigoín, Enrico Gratton 3124-Pos Board B332 ALL-ATOM STRUCTURE AND IONIC CONDUCTIVITY OF THE NUCLEAR PORE COMPLEX. David Winogradoff , Christopher Maffeo, Wei Si, Aleksei Aksimentiev 3125-Pos Board B333 SYNTHETIC MIMICS OF THE NUCLEAR PORE COMPLEX. Laura Maguire, Michael Stefferson, Katherine Rainey, Nathan Crossette, Eric Verbeke, Meredith Betterton, Loren Hough 3126-Pos Board B334 MONITORING THE TAGGED MRNA EXPORT RATE VIA NUCLEAR PORE COMPLEX IN LIVE CELLS WITH A SNAPSHOT. Yueyue Jing , Jingya Ye, Long- fang Yao, Lan Mi, Biao Dong, Jiong Ma Voltage-gated Na Channels (Boards B335–B362) 3127-Pos Board B335 ELUCIDATING THE SPECIFICITY AND BINDING RATE OF A SUBTYPE SELECTIVE SODIUM CHANNEL INHIBITOR WITH MOLECULAR DYNAMCIS SIMULATIONS. Ben Corry 3128-Pos Board B336 UNDERSTANDING NERVOUS SYSTEM EVOLUTION THROUGH NATURAL EXPERIMENTS: TETRODOTOXIN RESISTANCE IN SNAKES. Shana L. Geffeney , Gabriela Toledo, Charles T. Hanifin

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