Biophysical Society 62nd Annual Meeting | Program Guide

3275-Pos Board B483 OPTOGENETIC REGULATION OF MITOCHONDRIAL ROS EMISSION IN VIVO . Stephen Madamba, Nicomedes Rivera, Brian Nguyen, Pablo Peixoto 3276-Pos Board B484 MITOCHONDRIAL DYSFUNCTION DUE TO INTRACELLULAR BETA amYLOID OLIGOMERS. Patrick T. Toglia , Angelo Demuro, Ian Parker, Ghanim Ullah 3277-Pos Board B485 ENHANCED RESPIRATORY RESERVE SUSTAINED BY LIPID OXIDATION AND AUTOPHAGY UNDERLIE EXTENDED LIFESPAN IN HIGH- COMPARED TO LOW-RUNNING CAPACITY RATS. Sonia Cortassa , Miguel A. Aon, Mag- dalena Juhaszova, Jose A. Gonzalez-Reyes, Miguel Calvo-Rubio, Jose M. Villalba, Bruce Ziman, Sarah J. Mitchell, Irene Alfaras, Khalid Chakir, Jessie E C Axsom, Kelsey Bullock, Edward Lakatta, Steven J. Sollott 3278-Pos Board B486 LIPIDS CATALYZE MITOCHONDRIAL FISSION VIA GEOMETRIC INSTABIL- ITY. Ehsan Irajizad, Rajesh Ramachandran, Ashutosh Agrawal 3279-Pos Board B487 DOCOSAHEXAENOIC ACID REMODELS THE CARDIAC MITOCHONDRIAL PHOSPHOLIPIDOME AND IMPAIRS RESPIRATORY ENZYMATIC ACTIVITY BY DISRUPTING LIPID DOMAIN FORMATION AND LIPID-PROTEIN BIND- ING. Edward R. Pennington , E. Madison Sullivan, Genevieve C. Sparagna, James Washington, Ethan J. Anderson, Tonya N. Zeczycki, David A. Brown, Saame Raza Shaikh 3280-Pos Board B488 MITOCHONDRIAL QUALITY CONTROL IN AGING AND HEART FAILURE: INFLUENCE OF KETONE BODIES. Charles Miller, Maura Ferrero, Donald M. Bers, Elena N. Dedkova 3281-Pos Board B489 HIGH INTRINSIC AEROBIC ENDURANCE CAPACITY PRESERVES CARDIO- MYOCYTE QUALITY CONTROL, MITOCHONDRIAL FITNESS AND LIFES- PAN. Magdalena Juhaszova , Sonia Cortassa, Miguel A. Aon, José A. González-Reyes, Miguel Calvo-Rubio, José M. Villalba, Dmitry B. Zorov, Evgeny Kobrinsky, Bruce D. Ziman, Lauren G. Koch, Steven L. Britton, Edward G. Lakatta, Steven J. Sollott 3282-Pos Board B490 SIGNALING MECHANISMS OF DRP1 TRANSLOCATION TO THE MITO- CHONDRIA-SR ASSOCIATIONS IN ADULT MURINE CARDIOMYOCYTES.  Celia Fernandez Sanz , Sergio De La Fuente, Zuzana Nichtova, Sebastian Lanvermann, György Csordás, Wang Wang, Shey-Shing Sheu 3283-Pos Board B491 ENHANCING MITOCHONDRIAL BIOGENESIS WITH A CRISPR/NDCAS9 AD- ENOVIRAL VECTOR SYSTEM IN CARDIOMYOCYTES. Deepthi Ashok , Agnes Sidor, Brian O’Rourke 3284-Pos Board B492 CONSERVED DYNAMIC CHARACTERISTICS OF MITOCHONDRIAL NET- WORKS. Greyson Lewis , Wallace Marshall Systems Biology and Disease (Boards B493–B508) 3285-Pos Board B493 TARGETING PROTEOME-SCALE NETWORKS TO DESIGN AND SYNTHESIZE POTENT ANTICANCER AND CELL-SPECIFIC IMMUNOMODULATORY COM- POUNDS. Gaurav Chopra 3286-Pos Board B494 SYSTEMS ANALYSIS OF A COMBINED INTERACTOME OF LITHIUM-SENSI- TIVE PROTEINS . WEIHAO GE, Eric Jakobsson

3287-Pos Education Travel Awardee VIABLE PATHOGENIC ORGANISM TRANSPORTATION AND RECOVERY FROM A LOW-COST SUPPORT. Tonya Santaus , Chris Geddes 3288-Pos Board B496 CELLULAR ADHESIONS PREDICT MOBILITY PROPENSITIES OF EMT. Lewis Scott , Christopher Lemmon, Seth Weinberg 3289-Pos Board B497 CHEMICAL FLUCTUATION THEOREM GOVERNING VIBRANT REACTION NETWORKS IN LIVING CELLS.  Jaeyoung Sung 3290-Pos Board B498 STOCHASTIC ANALYSIS OF COAGULATION AND FRAGMENTATION OF SELF-ASSEMBLY BY SOLVING DISCRETE CHEMICAL MASTER EQUATION (DCME) WITH ACME. Farid Manuchehrfar , Wei Tian, Tom Chou, Jie Liang 3291-Pos Board B499 IDENTIFICATION AND CHARACTERIZATION OF VARIANT INTOLERANT SITES ACROSS HUMAN PROTEIN 3-DIMENSIONAL STRUCTURES. Sumaiya Iqbal , Jakob Berg Jespersen, Eduardo Perez-Palma, Patrick May, Henrike Heyne, Kasper Lage, Rikke Steensbjerre Møller, Florence F. Wagner, Mark Daly, Arthur J. Campbell, Dennis Lal 3292-Pos Board B500 TRANSLATIONAL REPROGRAMMING IN SALMONELLA TYPHIMURIUM MODIFIES ENVIRONMENTAL PH TO SUSTAIN HIGHER GROWTH RATES BEFORE ENTRY INTO STATIONARY PHASE. Manohary Rajendram , Lillian Zhu, Kerwyn C. Huang 3293-Pos Board B501 MECHANISTIC SYSTEMS MODELING TO IMPROVE UNDERSTANDING AND PREDICTION OF CARDIOTOXICITY CAUSED BY TARGETED CANCER THERA- PEUTICS.  Jaehee Shim 3294-Pos Board B502 RADIOPROTECTIVE EFFECTS OF LACTOBACILLI WITH ANTAGONISTIC ACTIVITIES AGAINST HUMAN PATHOGENS. Astghik Pepoyan , Marine Balayan, Anahit Manvelyan, Sofi Pepoyan, Lilit Malkhasyan, Tatevik Bezhanyan, Ruzanna Paronikyan, Margarita Malakyan, Sergey Bajinyan, Vardan Tsaturyan, Shigeru Kamiya, Michael Chikindas 3295-Pos Board B503 THE ROLE OF AUTOPHAGY IN ALZHEIMER’S DISEASE: MODELING AND SIMULATIONS. MooYoung Choi, Kyungreem Han , Jinwoong Kim 3296-Pos Board B504 ELECTRICAL SIGNAL TRANSMISSION IN A HETEROGENEOUS POPULATION OF BACTERIA.  Joseph W. Larkin , Xiaoling Zhai, Kaito Kikuchi, Aleksandra Walczak, Garcia-Ojalvo Jordi, Arthur Prindle, AndrewMugler, Gürol Süel 3297-Pos Board B505 A GUANINE NUCLEOTIDE EXCHANGE MODULATOR, GIV-GEM, ACTS AS A COMPARTMENTAL CONTROLLER FOR GROWTH FACTOR SIGNAL PATH- WAYS. Michael Getz , Pradipta Ghosh, Padmini Rangamani 3298-Pos Board B506 REFLECTED CONDUCTION ATTRIBUTED TO SODIUM CHANNEL DISTRIBU- TION WITHIN CARDIOMYOCYTES: A POSSIBLE MECHANISM OF VEN- TRICULAR FIBRILLATION INDUCTION IN BRUGADA SYNDROME. Kunichika Tsumoto , Yoshihisa Kurachi 3299-Pos Board B507 EXAMINING UBE3A’S POSSIBLE ROLE IN DENDRITIC SPINE MORPHOGEN- ESIS.  Judy E. Bloom , Carissa Sirois, Michael L. Blinov, Stormy J. Chamber- lain, Leslie M. Loew 3300-Pos Board B508 TUBERCULOSIS (TB) AND NOODLETREE: VERIFYING GENETIC SEQUENCE DATA AND FUNCTIONALITY OF A GENERALLY TRANSDUCED M. TUBERCU- LOSIS TOXIN THROUGH A VIRAL CARRIER. Britt Int-Hout , Lydia Flores Board B495

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