Biophysical Society 62nd Annual Meeting | Program Guide

Friday, February 16 Exhibitor Registration 8:00 am–5:00 pm, South Lobby Drug Discovery for Ion Channels XVIII Satellite Meeting 8:00 am–5:00 pm, Esplanade, Room 160

12:00 pm SODIUM CHANNEL ACTIVATORS: FROMMECHANISMS TO DRUG BINDING SITES. Jun Chen 12:30 pm LUNCH (PROVIDED) SESSION III Chair: Richard Kondo 1:30 pm BENCHMARKING ELECLAZINE: BIOPHYSICAL CHARACTERIZATION OF A CARDIAC LAE INA INHIBITOR. Kris Kahlig 2:00 pm A CHANNELOPATHY CALLED CANCER: FROM DISCOVERING NOVEL ROLES OF ION CHANNELS TO DESIGNING NOVEL PRECISION CANCER MEDICINE. Saverio Gentile 2:30 pm FUNCTIONAL ANNOTATION OF ION CHANNELS IMPLICATED BY HUMAN GENETICS WITH 384 CHANNEL APC. Jen Q. Pan 3:00 pm COFFEE BREAK SESSION IV Chair: Aaron Gerlach 3:30 pm A NEXT GENERATION OPTICAL PLATGE READER FOR CAPTURING DATA AT THE SPEED OF MEMBRANE BIOLOGY. Stephen Smith 3:55 pm TARGETING THE CU TRANSPORTER ATP7A FOR TREATMENT OF amYO- TROPHIC LATERAL SCLEROSIS (ALS). Robert Bowser 4:20 pm PHARMACOLOGICAL CHARACTERIZATION OF AN amINO ACID TRANS- PORTER AND HIS BACTERIAL HOMOLOGUE – A CASE STUDY USING SOLID SUPPORTED MEMBRANE TECHNOLOGY. Thomas Licher 4:45 pm MICROPLATE-BASED DYNAMIC OPTICAL STIMULATION OF HUMAN IPSC- DERIVED CARDIOMYOCYTES FOR ALL-OPTICAL CARDIOTOXICITY ASSAYS. Alex Savchenko 5:10 pm CLOSING REMARKS Aaron Gerlach

F R I D A Y

Sponsored by Sophion Bioscience together with Charles River; Icagen, Inc; and Nanion Technologies Ion channels are an important class of therapeutic drug targets, and mu- tations in ion channel genes are found to be responsible for an increasing number of diseases. While conventional electrophysiological techniques permit the most detailed and direct study of ion channel function, they are limited due to the manual nature of the method and their low throughput. Because of this, ion channels remain an underrepresented target class for drug discovery. The advent of higher throughput automat- ed electrophysiology systems has changed the face of ion channel drug discovery. Since the inaugural “Drug Discovery for Ion Channels” satellite meeting, there have been many advances in ion channel drug discovery including new instrumentation and techniques. This year’s meeting will highlight presentations from users of automated electrophysiology instrumentation as well as other speakers in the field of ion channel drug discovery, including several academic speakers. 8:00 am REGISTRATION 8:30 am WELCOME AND OPENING REMARKS Thais Johnson SESSION I Chair: Saverio Géntile 8:45 am NATURAL PRODUCTS AS PROBES OF THE PAIN PATHWAY: FROM PHYSIOL- OGY TO ATOMIC STRUCTURE. Keynote Speaker: David Julius 9:30 am HIGH-THROUGHPUT VALIDATION OF INCORPROATION OF UNNATURAL amINO ACIDS INTO AN ION CHANNEL. Stephan Pless 10:00 am KNOTBODIES TM : A NEW GENERATION OF ION CHANNEL THERAPEUTIC BIOLOGICS CREATED BY FUSING KNOTTIN TOXINS INTO ANTIBIODIES. Damian Bell 10:30 am COFFEE BREAK SESSION II Chair: Kris Kalig 11:00 am FINDING NAV1.1 ACTIATORS – DEVELOPMENT AND VALIDATION OF A HTS SUITABLE ASSAY. Julie Klint 11:30 am A NOVEL PAIN AND TARGET ENGAGEMENT ASSAY FOR HNAV1.7: EFFI- CACY IN INFLAMMATORY AND NEUROPATHIC PAIN MODELS CORRELATES WITH RESIDENCE TIME FOR INHIBITION OF NAV1.7. Charles Cohen

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