Biophysical Society 62nd Annual Meeting | Program Guide

Platform Protein-Small Molecule Interactions 10:45 am–12:45 pm, Esplanade, Room 155

169-Plat 11:15 am INTERACTION BETWEEN MYRISTOYLATED HUMAN ARF1 AND ASAP1 AT THE MEMBRANE SURFACE.  Yifei Li, Olivier Soubias , Jess Li, Paul A. Randazzo, R Andrew Byrd 170-Plat 11:30 am MEMBRANE BOUND STRUCTURE OF THE HIV-1 ACCESSORY PROTEIN NEF. Rebecca Eells , Kindra Whitlatch, Bradley Treece, Frank Heinrich, John Jeff Alvarado, Thomas E. Smithgall, Mathias Lösche 171-Plat 11:45 am CPOW Travel Awardee MOLECULAR INTERACTIONS OF THE MATRIX DOMAIN OF HIV-1 GAG PROTEIN AT THE MEMBRANE INTERFACE.  Viviana Monje-Galvan 172-Plat 12:00 pm OXIDATIVELY STRESSED MITOCHONDRIAL MEMBRANES: INSIGHT INTO THEIR ORGANIZATION AND FUNCTION DURING APOPTOSIS.  Artur P.G. Dingeldein, Tobias Sparrman, Jörgen Åden, Hanna Wacklin, Radek Šachl, Šárka Pokorná, Martin Hof, Gerhard Gröbner 173-Plat 12:15 pm IMPORTANCE OF MEMBRANE CURVATURE NEAR HOLE EDGES IN PLASMA MEMBRANE REPAIR.  Theresa Louise Boye, Weria Pezeshkian, Adam Cohen Simonsen , Jesper Nylandsted 174-Plat 12:30 pm NOT JUST IONIC MIMICRY: BIOPHYSICS OF TOXIC METAL ION INTERAC- TIONS WITH PERIPHERAL MEMBRANE TARGETS.  Tatyana I. Igumenova , Taylor R. Cole, Sachin Katti, Krystal A. Morales, Samuel G. Erickson, Min Woo Sung, Sarah B. Nyenhuis, Alexander B. Taylor, P. John Hart, Andreas Holzenburg, David S. Cafiso Undergraduate Student Pizza “Breakfast” 11:30 am–1:00 pm, North, Lower Lobby, Room 20/21 This “breakfast” for undergraduate students offers a valuable network- ing and social opportunity to meet other students, Biophysical Society Committee members, and scientists at all career levels to discuss aca- demic goals and questions, and to develop a biophysics career path. The Breakfast will include a panel discussion on academic and career paths in biophysics, with opportunities for questions and answers from the audi- ence–come prepared to find out about the course of study that aspiring biophysicists undertake, what it means to be a biophysicist, and how biophysicists make important discoveries. Space for this session is limited to the first 100 attendees. Exhibitor Presentation Carl Zeiss Microscopy LLC 11:30 am–1:00 pm, Exhibit Hall, Room 5 ZEISS Live Cell Imaging Tools Allow New Levels of Resolution, Sensitivity, and Throughput Imaging live cell samples offers unique insights into cellular function and gives the freedom to explore dynamic changes in cell behavior. Successful live cell imaging relies on maintenance of an appropriate cellular environ- ment and an effort to minimize cellular damage. Keeping up with dy- namic events inside a living cell requires an optical design that produces gentle high signal to noise images. The optical design and configuration of the imaging platform plays a crucial role in the success of an imaging experiment. ZEISS has introduced a completely automated inverted platform, the Celldiscoverer 7, which simplifies every aspect of experimental setup and gives every live cell experiment the best chance for success. At the heart of the Celldiscoverer 7 is a completely unique optical concept with record setting optical resolution and light throughput. Paired with gentle

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Co-Chairs Andrea Gohlke, The Beatson Institute for Cancer Research, United Kingdom Wieslaw Nowak, Institute of Physics, Nicolaus Copernicus University in Toruń, Poland 159-Plat 10:45 am A CENTRAL ROLE FOR BIOPHYSICS IN CANCER DRUG DISCOVERY–DE- VELOPMENT OF CANDIDATE SMALL MOLECULE INHIBITORS IN MUTANT KRAS.  Andrea Gohlke , Justin Bower, Peter N. Brown, Ken S. Cameron, Martin Drysdale, Gillian Goodwin, Christopher Gray, Jen Konczal, Duncan McArthur, Heather McKinnon, Mokdad Mezna, Angelo Pugliese, Alexan- der W. Schuettelkopf 160-Plat 11:00 am IDENTIFICATION OF THE FLEXIBLE REGIONS DIFFERENTIATING LIGAND- BINDING AFFINITY FOR MDM2 AND MDMX.  Zheng Su , Xiyao Cheng, Lingyun Qin, Rong Rong, Yongqi Huang 161-Plat 11:15 am International Travel Awardee PHOTOSWITCHABLE DRUGS AND INSULIN RELEASE: MOLECULAR EVENTS IN EPAC2A PROTEIN. Wieslaw A. Nowak , Lukasz Peplowski, Jakub Rydze- wski, Tomoo Miyahara, Haruki Nakamura, Hiroshi Nakatsuji 162-Plat 11:30 am REPEATABILITY OF ENTHALPIES AND GIBBS ENERGIES OF A PROTEIN–LI- GAND BINDING REACTION MEASURED BY ITC.  Vaida Paketuryte , Vaida Linkuviene, Daumantas Matulis 163-Plat 11:45 am BINDING POCKETS UNDER MECHANICAL STRESS. Matteo Tiberti, Bob- Dan Lechner, Arianna Fornili 164-Plat 12:00 pm NEUTRON DIFFRACTION STUDIES OF A NON-CANONICAL CATALYTIC TRIAD OF A LESS PROMISCUOUS amINOGLYCOSIDE ACETYLTRANSFERASE. Fnu Prashasti 165-Plat 12:15 pm MEASURE SMALL MOLECULE-MEMBRANE PROTEIN BINDING KINETICS WITH NANO-OSCILLATORS.  Guangzhong Ma 166-Plat 12:30 pm PORPHYRIN-INDUCED MULTIMERIZATION OF SOLUTION-STATE PRO- TEINS.  Oleksandr Kokhan , Daniel Marzolf, Coleman Swaim Platform Protein-Lipid Interactions I 10:45 am–12:45 pm, Esplanade, Room 156 Co-Chairs Tatyana Igumenova, Texas A&M University Matthias Buck, Case Western Reserve University 167-Plat 10:45 am MEHANISMS IN CANCER SIGNALING: THE ROLE OF THE MEMBRANE IN THE RECRUITMENT OF THE ONCOGENE KRAS4B.  Stephen G. Sligar , Michael C. Gregory, Mark A. McLean 168-Plat 11:00 am HOW TOPOLOGY CORRELATES TO DYNAMICS AND FUNCTION FOR MEM- BRANE PERIPHERAL PROTEIN COMPLEX.  Zhenlu Li , Matthias Buck

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