Biophysical Society 62nd Annual Meeting | Program Guide

197-Plat 5:30 pm SUBSTRATE STIFFNESS AND WORK AFFECTS MYOCYTE HYPERTROPHY AND CAPZ DYNAMICS VIA PKC-EPSILON AND PIP2 SIGNALING PATHWAYS. Christopher Solís , Michael Mkrtschjan, Brenda Russell 198-Plat 5:45 pm PRE-ACTIVATION OF CARDIOMYOCYTES DETERMINES CONTRACTILE FORCE AND SPEED OF CONTRACTION; ROLE OF TITIN AND CALCIUM.  Diederik W. Kuster , Michiel Helmes, Aref Najafi, Maike Schuldt, Jolanda van der Velden Platform Voltage-gated Na and Ca Channels 4:00 pm–6:00 pm, Esplanade, Room 153 Co-Chairs Sudha Chakrapani, Case Western Reserve University Toni Schneider, University of Cologne, Germany 199-Plat 4:00 pm FENESTRATION MUTANTS OF A VOLTAGE-GATED SODIUM CHANNEL THAT MODIFY CHANNEL BLOCKER INGRESS.  Giulia Montini , Altin Sula, Andrew J. Miles, B A. Wallace 200-Plat 4:15 pm CHARACTERIZATION OF PHOTOSWITCHABLE SODIUM CHANNEL INHIBI- TORS BY PLANAR PATCH CLAMP.  Nils Winter, Andrea Brüggemann , Claudia Haarmann, Michael George, Niels Fertig, Martin Sumser, Dirk 4:30 pm STRUCTURAL DYNAMICS OF SLOW-INACTIVATION IN A VOLTAGE- GATED SODIUM CHANNEL.  Soumili Chatterjee , Rajan Vyas, Sreevatsa Chalamalasetti, Indra D. Sahu, Jerome Clatot, Gary A. Lorigan, Isabelle Deschenes, Sudha Chakrapani 202-Plat 4:45 pm STRUCTURAL MODELING OF LOCAL ANESTHETIC AND ANTIARRHYTHMIC DRUG BINDING TO THE HUMAN CARDIAC VOLTAGE GATED SODIUM CHANNEL.  Phuong T. Nguyen , Kevin R. DeMarco, Igor Vorobyov, Colleen E. Clancy, Vladimir Yarov-Yarovoy 203-Plat 5:00 pm INSIGHTS INTO SODIUM CHANNEL GATING ENABLED BY TRANSPLANTA- TION OF AN ARYL SULFONAMIDE DRUG BINDING SITE IN COMBINATION WITH GENETICALLY-ENCODED CROSS LINKING.  Daniel T. Infield , Samuel J. Goodchild, Jason D. Galpin, Christopher A. Ahern 204-Plat 5:15 pm OPTICALLY-TRACKED STRUCTURAL REARRANGEMENTS OF THE VOLTAGE SENSING DOMAINS IN THE HUMAN CA V 1.1 CHANNEL.  Nicoletta Savalli , Fenfen Wu, Marbella Quinonez, Stephen C. Cannon, Riccardo Olcese 205-Plat 5:30 pm ISOPROTERENOL PROMOTES AUGMENTATION OF L-TYPE CA V 1.2 CHAN- NEL CLUSTERING AND COOPERATIVE GATING IN VENTRICULAR MYO- CYTES.  Danica W. Ito , Karen I. Hannigan, Luis F. Santana, Rose E. Dixon 206-Plat 5:45 pm DISTURBANCES OF TRANSRETINAL SIGNALING AFTER ABLATION OF CA V 2.3 / R-TYPE CALCIUM CHANNELS.  Toni Schneider , Jan Niklas Lüke, Isha Akhtar, Felix Neumaier, Gerrit Alexander Schubert, Hans Clusmann, Jürgen Hescheler, Matthias Lüke, Walid Albanna Platform Trauner 201-Plat

185-Plat 4:30 pm A BAYESIAN INTEGRATIVE STRUCTURE MODEL OF THE YEAST CENTRO- SOME.  Shruthi Viswanath , Massimiliano Bonomi, Seung Joong Kim, Vadim A. Klenchin, Keenan Taylor, King C. Yabut, Neil T. Umbreit, Janet Meehl, Michele H. Jones, Javier Velazquez-Muriel, Mark Winey, Ivan Rayment, Trisha N. Davis, Andrej Sali, Eric D. Muller 186-Plat 4:45 pm COILED COIL PROTEINS AS SCAFFOLD FOR BROAD RANGE, ULTRAFAST BIOSENSORS.  ameed Hashmi , Florence R. Lucey, Mourad Sadqi, Victor Muñoz 187-Plat 5:00 pm MOLECULAR DESIGN AND X-RAY CRYSTAL STRUCTURE OF ENGINEERED PHOSPHOLAMBAN TRANSMEMBRANE VARIANT. Marco Mravic , J. Thomaston, William F. DeGrado 188-Plat 5:15 pm MAINMAST: DE NOVO MAIN-CHAIN MODEL TRACING FOR EMMAPS USING TREE-GRAPH OPTIMIZATION METHOD.  Genki Terashi , Daisuke Kihara 189-Plat 5:30 pm EXPLORING FOLDING FEATURES IN PROTEIN STRUCTURE PREDICTION.  Saulo H.P. de Oliveira , Charlotte M. Deane 190-Plat 5:45 pm PREDICTING PROTEIN CONTACT MAPS DIRECTLY FROM PRIMARY SE- QUENCE WITHOUT THE NEED FOR HOMOLOGS.  Thrasyvoulos Karydis , Joseph M. Jacobson Platform Cardiac Muscle Mechanics, Structure, and Regulation I 4:00 pm–6:00 pm, South, Level Two, Room 215/216 Co-Chairs Vitold Galkin, Eastern Virginia Medical School Mathias Gautel, King’s College London, United Kingdom 191-Plat 4:00 pm ALLOSTERIC MODULATION OF CARDIAC MYOSIN DYNAMICS BY OMECAMTIV MECARBIL.  Shaima Hashem , Matteo Tiberti, Arianna Fornili 192-Plat 4:15 pm PHOSPHOINOSITIDE-MEDIATED MYOSIN-1 MEMBRANE TARGETING DUR- ING ENDOCYTOSIS.  Girish Rajendraprasad, Tim Scholz, Matthias Preller, Georgios Tsiavaliaris 193-Plat 4:30 pm THE MOLECULAR DEFECTS IN CA 2+ REGULATION DUE TO MUTATIONS THAT CAUSE HYPERTROPHIC CARDIOMYOPATHY CAN BE REVERSED BY SMALL MOLECULES THAT BIND TO TROPONIN.  Steven B. Marston , An- drew E. Messer, Juan Eiros-Zamora, Ian Gould, Maria Papadaki, Afnan Choudry, Alice Sheehan 194-Plat 4:45 pm HIGH-THROUGHPUT SCREENING FOR ACTIN-BINDING COMPOUNDS THAT AFFECT ACTOMYOSIN STRUCTURE AND FUNCTION USING TIME-RE- SOLVED FRET.  Piyali Guhathakurta , Ewa Prochniewicz, Kurt C. Peterson, Benjamin D. Grant, Gregory D. Gillispie, David D. Thomas 195-Plat 5:00 pm CONTROLLING CARDIAC CONTRACTILITY AT THE SINGLE MOLECULE LEVEL.  Chao Liu , Dan L. Song, Masataka Kawana, Kathleen M. Ruppel, James A. Spudich 196-Plat 5:15 pm NON-LINEAR MODEL FOR MECHANICAL ENTRAINMENT OF CARDIOMYO- CYTES.  Ohad Cohen , Samuel A. Safran

F R I D A Y

S U N D A Y

Excitation-Contraction Coupling 4:00 pm–6:00 pm, Esplanade, Room 154

Co-Chairs Siobhan Wong, University of British Columbia, Canada Leighton Izu, University of California, Davis

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