Biophysical Society 62nd Annual Meeting | Program Guide

273-Pos Board B43 IS HYDROYDRODYNAMIC INTERACTION IMPORTANT TO PROTEIN FOLD- ING? Dirar M. Homouz , Fabio C. Zegarra, Yossi Eliaz, Margaret S. Cheung 274-Pos Board B44 International Travel Awardee SOD1 FOLDING MODULATION IN THE CROWDED CELL. David Gnutt , Jonas Ahlers, Benedikt König, Matthias Heyden, Simon Ebbinghaus 275-Pos Board B45 AGGREGATION AND STABILITY OF PROTEINS IN WATER: A COMPUTA- TIONAL STUDY. Valentino Bianco 276-Pos Board B46 THERMODYNAMICALLY COUPLED UNFOLDING TRANSITIONS IN DYSTRO- PHIN ABD1. Christian Coffman , Robert Miller, Victoria Fringer, Erin Groth, Adewale Adeyemi, Alexis Doucette, Michelle Botts, Michael Fealey, Jes- sica Sieber, Anne Hinderliter 277-Pos Board B47 PROBING REGIONAL SOLVENT ACCESSIBILITY OF MOLTEN GLOBULES AND FOLDING INTERMEDIATES USING X-RAY FOOTPRINTING/MASS SPECTROMETRY. Shawn M. Costello , Sayan Gupta, Corie Y. Ralston, Susan Marqusee 278-Pos Board B48 SPECTRA AND SIMULATION OF MODEL BETA-SHEETS AND HAIRPINS. IM- PACT OF TURN SEQUENCES AND AROMATIC CONTACTS ON EQUILIBRIA AND DYNAMICS. Timothy A. Keiderling , Heng Chi, Dan McElheny, David Scheerer, Ayesha Samer, Karin Hauser, Frank Vazquez 279-Pos Board B49 EFFECTS OF AGGREGATING AGENTS IN PROTEIN MISFOLDING. AN INFRA- RED SPECTROSCOPY STUDY.  Jose Luis R. Arrondo , Laura Aguirre Araujo, Igor De la Arada 280-Pos Board B50 MOLECULAR DYNAMICS INVESTIGATIONS OF Β-SHEET STABILITY AND FOLDING PATHWAYS. Anthony Hazel , Chris Rowley, James C. Gumbart 281-Pos Board B51 FOLDING THERMODYNAMICS OF A THREE-HELIX BUNDLE PROTEIN AND ITS ENGINEERED THERMOSTABLE VARIANT. Emily K. Hamlin , Srivarchala Chandu, Michelle E. McCully 282-Pos Board B52 FOLDING ANALYSES OF A DE NOVO DESIGNED PROUROGUANYLIN.  Yuji Hidaka , Saya Nishihara, Kenta Mori, Shigeru Shimamoto 283-Pos Board B53 IDENTIFICATION AND CHARACTERIZATION OF AN INSIDE-OUT INTER- MEDIATE IN THE FOLDING PATHWAY OF BACTERIOPHAGE SLIDING CLAMP. Manika I. Singh, Vikas Jain 284-Pos Board B54 MONITORING THE FOLDING PATHWAY OF A PROTEIN OVER EVOLUTION- ARY TIME USING HYDROGEN EXCHANGE–MASS SPECTROMETRY (HX- MS). Eric Bolin , Shion Lim, Susan Marqusee Protein-Small Molecule Interactions I (Boards B55–B73) 285-Pos Board B55 MAPPING LIGAND BINDING LANDSCAPES WITH WEXPLORE. Alex Dickson 286-Pos Board B56 RATIONAL DESIGN OF AGO-ALLOSTERIC SMALL MOLECULE OF GLP- 1R. Tejashree Redij , Rajan Chaudhari, Zhiyu Li, Zhijun Li

259-Pos Board B29 MOLECULAR DYNAMICS SIMULATION OF THE KAIC CLOCK PROTEIN.  Theo Crouch , Andy LiWang, Michael E. Colvin 260-Pos Board B30 CASTP 3.0: COMPUTED ATLAS OF SURFACE TOPOGRAPHY OF PROTEINS AND BEYOND. Wei Tian , Chang Chen, Jie Liang 261-Pos Board B31 MOLECULE MECHANICS FROM CRYO-EM IMAGES AND MULTIPLE RECONSTRUCTED DENSITIES. Christian Blau , Erik Lindahl Protein Stability, Folding, and Chaperones I (Boards B32–B54) 262-Pos Board B32 FLEXIBILITY OF THE GLOBAL PROTEIN STRUCTURE DEFINES THE MULTIPLE CONFORMATIONS OF THE LACTATE DEHYDROGENASE AT THE STAGE PRECEDING IRREVERSIBLE THERMAL INACTIVATION. Sergei Khrapunov , Eric P. Chang, Robert H. Callender 263-Pos Board B33 CONFORMATIONAL CHANGES OF Α-CRYSTALLIN PROTEINS INDUCED BY HEAT STRESS. Ming-Tao Lee , Yu-Yung Chang, Wei-Chin Hung 264-Pos Board B34 DENATURED STATE CONFORMATIONAL BIAS IN A 3-HELIX BUNDLE.  Moses Leavens , Bruce Bowler, Melisa M. Cherney 265-Pos Board B35 THE POLYDISPERSITY PROBLEM: INVESTIGATING THE EFFECT OF CROWD- ING AGENT POLYDISPERSITY IN PROTEIN STABILITY. Alan van Giessen , Anastasia Osti 266-Pos Board B36 THE ROLE OF TMAO IN PROTEIN FOLDING: A JOINT EXPERIMENTAL AND SIMULATION STUDY. Mayank M. Boob , Shahar Sukenik, Taras V. Pogore- lov, Martin Gruebele 267-Pos Board B37 MICROSCALE FOLDAMER PRODUCTION AND CHARACTERIZATION.  Roxanna Kiessling , Katherine Snell, Collin Barraugh, Samuel J.S. Rubin, Babak Sanii 268-Pos Board B38 MOLECULAR EVOLUTION OF L-PGDS: SUBSTRATE RECOGNITION MECHA- NISM OF MEDAKA L-PGDS. Kimi Torii , Yuji Hidaka, Shigeru Shimamoto 269-Pos Board B39 DISULFIDE-COUPLED FOLDING OF PROUROGUANYLIN ON MOLECULAR EVOLUTION. Kenta Mori , Saya Nishihara, Shigeru Shimamoto, Yuji Hidaka 270-Pos Board B40 COMPARATIVE REFOLDING OF GUANIDINIUM HYDROCHLORIDE DENA- TURED SERUM ALBUMIN ASSISTED BY SURFACTANTS VIA ARTIFICIAL CHAPERONE PROTOCOL: BIOPHYSICAL INSIGHT. Mohd Ishtikhar , Nand Education Travel Awardee INVESTIGATION OF THE MOLECULAR MECHANISMS WHICH RESULT IN amINOGLYCOSIDE NUCLEOTIDYLTRANSFERASE 4’ (ANT4) VARIANTS WITH DIFFERENT LEVELS OF THERMOSTABILITY. Seda Kocaman , Brinda Selvaraj, Edward Wright, Matthew Cuneo, Engin Serpersu 272-Pos Board B42 OBSERVATION OF THE COOPERATIVE COLLAPSE IN THE SPONTANEOUS FOLDING PROCESS OF CYTOCHROME C BY TWO-DIMENSIONAL FLUO- RESCENCE LIFETIME CORRELATION SPECTROSCOPY. Miyuki Sakaguchi , Masaru Yamanaka, Shun Hirota, Kunihiko Ishii, Tahei Tahara Kishore 271-Pos Board B41

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