Biophysical Society 62nd Annual Meeting | Program Guide

356-Pos Board B126 CO-TRANSLATIONAL TARGETING BY SIGNAL RECOGNITION PARTICLE ACTIVATES ONLY AFTER CYTOSOLIC EXPOSURE OF SIGNAL SEQUENCE.  Hao Hsuan Hsieh , Shu-ou Shan 357-Pos Board B127 PROTEIN:PROTEIN INTERACTIONS CONTROL SENSITIVITY OF A TRAN- SCRIPTION RESPONSE TO INPUT SIGNAL. Dorothy Beckett , Chenlu He, Jingheng Wang, Gregory Custer, Silvina Matysiak 358-Pos Board B128 CONFORMATION-INDEPENDENT DYNAMICS OF O 2 REBINDING TO MYO- GLOBIN. Seongchul Park, Jaeheung Park, Joohyang Shin, Manho Lim 359-Pos Board B129 MECHANISMS OF OUTPUT SIGNALING FROM A CIRCADIAN OSCILLA- TOR.  Jeffrey A. Swan , Joel Heisler, Courtney Dailley, Andy LiWang, Carrie Board B130 CHARACTERIZING THE STRUCTURAL AND FUNCTIONAL ROLE OF W215 IN THROMBIN. Riley Peacock , Jessie Davis, Elizabeth Komives Membrane Protein Dynamics I (Boards B131–B158) 361-Pos Board B131 MECHANISM OF PROTEIN TARGETING TO LIPID DROPLETS. Morris E. Sharp , Coline Prevost, Maria-Jesus Olarte, Robert V. Farese Jr., Tobias C. Walther, Gregory A. Voth 362-Pos Board B132 DYNAMIC CHARACTERIZATION OF PHOTOSYNTHETIC PROTEINS ON THYLAKOID MEMBRANES BY HIGH-SPEED AFM. Bibiana Onoa , Shingo Fukuda, Masakazu Iwai, Krishna K. Niyogi, Carlos Bustamante 363-Pos Board B133 HIGH-SPEED AFM CORRELATION SPECTROSCOPY (HS-AMF-CS): µS PRO- TEIN DYNAMICS WITHOUT LABELS. George R. Heath , Beatrice Ramm, Petra Schwille, Simon Scheuring 364-Pos Board B134 INVESTIGATION OF THERMODYNAMIC DISSOCIATION KINETICS TO DETERMINE THE BINDING STRENGTHS WITHIN A MEMBRANE PROTEIN COMPLEX: PHOTOSYSTEM II SUPERCOMPLEX. Eunchul Kim , Ryutaro Tokutsu, Akimasa Watanabe, Jun Minagawa 365-Pos Board B135 CYTOCHROME P450 PREFERS TO BE IN LIQUID-ORDERED DOMAINS IN THE ENDOPLASMIC RETICULUM. Carlo Barnaba , Bikash R. Sahoo, Ayy- alusamy Ramamoorthy 366-Pos Board B136 IN VIVO X-RAY MONITORING OF DYNAMICS BETWEEN INTERLEUKIN 2 AND INTERLEUKIN 15 ON NK CELLS.  Jaewon Chang , Masahiro Kuramochi, Youngsuk Beak, Kouhei Ichiyanagi, Hiroshi Sekiguchi, Yuji C. Sasaki 367-Pos Board B137 NEURONAL KV2.1 CLUSTERS INFLUENCE THE DIFFUSION LANDSCAPE OF THE ADJACENT ASTROCYTE MEMBRANE. Ashley N. Leek , Diego Krapf, Michael Tamkun 368-Pos Board B138 THE TYROSINE KINASE LCK TRANSLATIONAL DYNAMICS AND ITS INTER- RELATION WITH ITS CONFORMATIONAL STATE. Geva Hilzenrat , Elvis Pandzic, Katharina Gaus L. Partch 360-Pos

343-Pos Board B113 FEEDFORWARD AND FEEDBACK amPLIFICATION IN THE PINK1-PARKIN PATHWAY GENERATE A BINARY SWITCH FOR MITOCHONDRIAL QUALITY CONTROL IN PARKINSON DISEASE. Kalle Gehring 344-Pos Board B114 REGULATION OF THE PROMOTER OF RNA SILENCING. Suzanne Scarlata , Shriya Sahu, Leo Williams, Alberto Perez, Finly Philip, Giuseppe Caso, Walter Zurawsky 345-Pos Board B115 IDP SEGMENT CONSERVATION AND DIVERGENCE IN I-DOMAINS OF THE PHAGE LAMBDA SUPERCLUSTER. Andrei T. Alexandrescu , Therese N. Tripler, Anne R. Kaplan, Kristin N. Parent, Carolyn M. Teschke 346-Pos Board B116 ROLE OF CONFORMATIONAL ENTROPY IN EXTREMELY HIGH AFFINITY PROTEIN INTERACTIONS.  Jose A. Caro , Kathleen G. Valentine, A. Joshua Wand 347-Pos Board B117 EVALUATING HOW BINDING INTERACTIONS FOR PARS CHANGE AS PROTHROMBIN IS CONVERTED TO THROMBIN. Ramya Billur , Thomas Michael Sabo, Muriel C. Maurer 348-Pos Board B118 A SINGLE MUTATION ON A SURFACE LOOP ALTERS THE KEY DYNAMICS OF THE DISTANT ACTIVE SITE: HIGH PRESSURE AND RELAXATION DISPER- SION NMR STUDIES OF E.COLI DIHYDROFOLATE REDUCTASE.  Kazuyuki Akasaka 349-Pos Board B119 STRUCTURAL INSIGHT INTO THE METAL-ION MEDIATED MODULATION OF THE CATALYTIC FUNCTION OF H. PYLORI ARGINASE. Ankita Dutta , Mohit Mazumder, Mashkoor Alam, Samudrala Gourinath, Apurba Kumar Sau 350-Pos Board B120 DYNAMIC OF APOBEC3G IN COMPLEX WITH SSDNA REVEALED BY HIGH- SPEED AFM. Yangang Pan , Zhiqiang Sun, Luda S Shlyakhtenko, Reuben S Harris, Yuri L Lyubchenko 351-Pos Board B121 RELATING THE VIBRATIONAL LINESHAPES OF THE THIOCYANATE (SCN) PROBE TO STRUCTURES AND DYNAMICS IN CALMODULIN ENSEMBLES VIA COMPUTATIONAL APPROACHES. Rosalind J. Xu , Shannon R. Dalton, Kristen L. Kelly, Casey H. Londergan 352-Pos Board B122 DYNAMIC OBSERVATION OF KAI PROTEINS BY HS-AFM REVEALS A MECHANISM OF THE ROBUSTNESS IN THE CYANOBACTERIAL CIRCADIAN OSCILLATOR. Shogo Sugiyama , Tetsya Mori, Mark Byrne, Takayuki Uchi- hashi, Carl H. Johnson, Toshio Ando 353-Pos Board B123 USING A FLUORESCENT UNNATURAL amINO ACID TO CHARACTERIZE THE CONTRIBUTION OF PRE AND POST-CHEMISTRY ENZYME STRUCTURAL DYNAMICS TO HIGH FIDELITY DNA REPLICATION. Tyler Dangerfield 354-Pos Board B124 PROBING SUBSTRATE SEQUESTRATION IN CARRIER PROTEINS USING VI- BRATIONAL SPECTROSCOPY LABELS AND MOLECULAR DYNAMIC SIMULA- TIONS. Caroline A. McKeon , Louise K. Charkoudian, Casey H. Londergan 355-Pos Board B125 DEVELOPMENT AND CHARACTERIZATION OF TWO PHENYLALANINE

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DERIVATIVES FOR USE AS RAMAN PROBES IN PROTEINS.  Eliana V. von Krusenstiern , Joie Ling, Casey H. Londergan

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