Biophysical Society 62nd Annual Meeting | Program Guide

369-Pos Board B139 DOMAIN INTERFACES FACILITATE PROTEIN ASSOCIATION AND AGGREGA- TION IN MULTICOMPONENT LIPID BILAYERS. Asanga Bandara Ekanayaka Mudiyanselage , Afra Panahi, George A. Pantelopulos, John E. Straub 370-Pos Board B140 TLR4 RECRUITMENT INTO LIPID RAFTS STUDIED BY COARSE GRAINED MD SIMULATION. Paulo C. T. Souza , Tsjerk A. Wassenaar, Munir S. Skaf, Siewert J. Marrink 371-Pos Board B141 A NOVEL COMPUTATIONAL FRAMEWORK FOR D ( T ) FROM FRAP DATA REVEALS VARIOUS ANOMALOUS DIFFUSION TYPES. Minchul Kang 372-Pos Board B142 IN VIVO MEASUREMENTS OF TETRASPANIN 8 INTERACTIONS IN LIVING CELLS. Daniel Wirth 373-Pos Board B143 MOLECULAR BASIS OF EPHA2 PRE-OLIGOMERS AND THE INHIBITORY FUNCTION OF ITS SAM DOMAIN. Xiaojun Shi , Ryan Lingerak, Chuan Yu, Jeannine Muller-Greven, SoonJeung Kim, Paloma Gill-Rodriguez, Fatima Raeselle Javier, Deanna Bowman, Yixuan Hou, Yifan Ge, Matthias Buck, Bingcheng Wang, AdamW. Smith 374-Pos Board B144 INTERACTIONS BETWEEN THE TRANSMEMBRANE DOMAINS OF PLEXIN, SEMAPHORIN, AND NEUROPILIN. Shaun M. Christie , Soon-Jeung Kim, Paul D. Toth, Jeannine Muller-Greven, Matthias Buck, AdamW. Smith 375-Pos Board B145 COMPUTATIONALLY DETERMINED FREE ENERGY PROFILES OF THE MUCIN-1 TRANSMEMBRANE HOMODIMER. Christina M. Freeman , Alexander J. Sodt 376-Pos Board B146 DECIPHERING THE ROLE OF FISB DURING SPORULATION OF BACILLUS SUBTILIS THROUGH MUTAGENESIS. Anna Georgieva , Ane Landajuela, Erdem Karatekin 377-Pos Board B147 ORGANIZATION OF I-BAR PROTEINS ON TUBULAR AND VESICULAR MEM- BRANES. Zack Jarin , Feng-Ching Tsai, Patricia Bassereau, Gregory A. Voth 378-Pos Board B148 INTERACTION OF KRAS4B PROTEIN WITH C6-CERAMIDE CONTAINING LIPID MODEL MEMBRANES. Lei Li , Roland Winter 379-Pos Board B149 LIPID-ANCHORED RAS PROTEINS SENSE/MODULATE PLASMA MEM- BRANE CURVATURE IN AN ISOFORM- SPECIFIC MANNER. Hong Liang, Alemayehu Gorfe, John F. Hancock, Yong Zhou 380-Pos Board B150 MEMBRANE ALLOSTERY RECRUITS UNIQUE HYDROPHOBIC BINDING SITES PROMOTING SUBSTRATE SPECIFICITY OF LIPOLYTIC ENZYMES.  Varnavas D. Mouchlis , J. AndrewMcCammon, Edward A. Dennis 381-Pos Board B151 INVESTIGATING COMPLEX FORMATION OF C99 WITH GAMMA-SECRE- TASE, USING ATOMISTIC MM-MD SIMULATIONS AND FREE ENERGY CALCULATIONS. Manuel Hitzenberger , Martin Zacharias 382-Pos Board B152 MODELING OF CLAUDIN-15 PARACELLULAR CHANNELS VIA MOLECULAR DYNAMICS SIMULATIONS. Giulio Alberini , Fabio Benfenati, Luca Mara- gliano 383-Pos Board B153 EFFECT OF MILD AND HARSH DETERGENTS ON THE STABILITY OF THE MODEL MEMBRANE PROTEIN PROTEORHODOPSIN. Sadegh Faramarzi , Blake Mertz

384-Pos Board B154 INTERROGATING MEMBRANE PROTEIN CONFORMATIONAL DYNAMICS WITHIN NATIVE LIPID BILAYERS WITH HYDROGEN-DEUTERIUM EX- CHANGE MASS SPECTROMETRY. Eamonn Reading 385-Pos Board B155 ASSESSING THE STRUCTURE OF TRANSMEMBRANE OLIGOMERIC IN- TERMEDIATES OF AN ΑHELICAL TOXIN USING MOLECULAR DYNAMICS SIMULATIONS. Rajat Desikan, Ganapathy Ayappa , Prabal K. Maiti 386-Pos Board B156 INCLUDING H-BONDING AND LIPID EXPOSURE IN NEAR-ATOMIC LEVEL FOLDING SIMULATIONS OF HELICAL MEMBRANE PROTEINS: II. APPLICA- TIONS TO SINGLE-MOLECULE FORCE SPECTROSCOPY. Zongan Wang 387-Pos Board B157 CONTINUUM THEORY OF HIV-BUDDING. Sanjay Dharmavaram , Baochen She, Ioulia Rouzina, Robijn Bruinsma 388-Pos Board B158 TOWARDS PIECING TOGETHER THE RAS-RAF PUZZLE: DYNAMICS OF MEMBRANE-ASSOCIATED KRAS4B-RAF RBD/CRD TERNARY COM- PLEX. Timothy Travers , Cesar A. López, S. Gnanakaran Intrinsically Disordered Proteins (IDPs) and Aggregates I (Boards B159–B185) 389-Pos Board B159 Α-SYNUCLEIN IS A NEURON SPECIFIC LECTIN. Melissa Birol , Siobhan Toal, Elizabeth Rhoades 390-Pos Board B160 EXPLORING THE ROLE OF O 2 ON THE METAL ION SPECIFIC MODULATION OF ALPHA-SYNUCLEIN STRUCTURE. Heather R. Lucas 391-Pos Board B161 INVESTIGATIONS ON THE FACTORS RESPONSIBLE FOR THE CYTOCHROME C-ALPHA SYNUCLEIN BINDING-AGGREGATION LANDSCAPE.  Sumanta Ghosh 392-Pos Board B162 ILLUMINATING THE SELF-ASSEMBLY OF ALPHA-SYNUCLEIN amYLOID FIBRILS.  Jervis V. Thevathasan , Jonas Ries 393-Pos Board B163 ALPHA-SYNUCLEIN MODULATION OF VESICLE EXOCYTOSIS IN SECRETORY CELLS. Meraj Ramezani , Marcus Wilkes, Tapojyoti Das, David Eliezer, David Holowka, Barbara Baird 394-Pos Board B164 DEVELOPING NOVEL FRET BASED BIOSENSORS THAT MONITOR Α-SYNUCLEIN ASSEMBLY FOR USE IN HIGH THROUGHPUT SCREEN- ING. Malaney Young , Anthony R. Braun, Jonathan N. Sachs, Chi Hung Lo 395-Pos Board B165 INTERACTION OF THE COPPER CHAPERONE ATOX1 WITH ΑLPHA- SYNUCLEIN.  Istvan Horvath , Tony Werner, Pernilla Wittung-Stafshede 396-Pos Board B166 CHARACTERIZING ALPHA-SYNUCLEIN BINDING TO GLYCANS. Karen Acosta , Elizabeth Rhoades 397-Pos Board B167 STRUCTURAL DYNAMICS OF MONOMERIC Α-SYNUCLEIN ON THE PS-µS TIME SCALE DERIVED FROMMD SIMULATIONS. Reinhard Klement , Timo Graen, Asaf Grupi, Elisha Haas, Helmut Grubmueller 398-Pos Board B168 SYSTEMATIC DEVELOPMENT OF SMALL MOLECULES TO INHIBIT SPECIFIC STEPS OF Α-SYNUCLEIN AGGREGATION IN PARKINSON’S DISEASE.  Roxine Staats , Patrick Flagmeier, Michele Vendruscolo

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