Biophysical Society 62nd Annual Meeting | Program Guide

Platform Calcium Channels and Signaling 4:00 pm–6:00 pm, Esplanade, Room 154

1058-Plat 5:30 pm DENGUE VIRUS STRAIN 2 CONFORMATIONS AND ITS STRUCTURAL DYNAMICS–ROLES OF DIVALENT IONS AND TEMPERATURE.  Kamal Kant Sharma , Xin-Xiang LIM, Sarala N. Tntirimudalige, Anjali Gupta, Jan K. Marzinek, Xin Yin Elisa LIM, Shee-Mei Lok, Peter J. Bond, Ganesh S. Anand, Thorsten Wohland 1059-Plat 5:45 pm HIGH-RESOLUTION NEUTRON SCATTERING DATA REVEAL THE DECOU- PLING OF PROTEINS AND WATER AT THE DYNAMICAL TRANSITION.  Antonio Benedetto Platform

M O N D A Y

Co-Chairs Eamonn Dickson, University of California, Davis Romana Schober, Johannes Kepler University Linz, Austria 1068-Plat 4:00 pm

ROLE OF NPC1 IN REGULATING STORE-OPERATED CALCIUM ENTRY: LES- SONS FROM NIEMANN PICK TYPE C DISEASE.  Scott A. Tiscione , Oscar Vivas, Eamonn J. Dickson 1069-Plat 4:15 pm MOLECULAR INSIGHTS INTO THE PATHOPHYSIOLOGY OF THE CA 2+ SENS- ING PROTEIN STIM1.  Romana Schober , Irene Frischauf, Victoria Lunz, Christoph Romanin, Rainer Schindl 1070-Plat 4:30 pm MIXED SIGNALS: INTERACTION BETWEEN RYR AND IP 3 R MEDIATED CAL- CIUM RELEASE SHAPES THE CALCIUM TRANSIENT FOR HYPERTROPHIC SIGNALLING IN CARDIOMYOCYTES.  Hilary Hunt , Gregory Bass, Llewelyn Roderick, Christian Soeller, Vijay Rajagopal, Edmund Crampin 1071-Plat 4:45 pm IP 3 -INDUCED SR-CA 2+ RELEASE FUNCTIONS AS AN ANTI-ARRHYTHMO- GENIC MECHANISM IN VENTRICULAR MYOCYTES.  Joaquim Blanch Salvador , Marcel Egger 1072-Plat 5:00 pm FRET-BASED MAPPING AND MILLISECOND STRUCTURAL KINETICS OF CALMODULIN BOUND TO RYANODINE RECEPTOR CHANNELS.  Robyn T. Rebbeck , Bengt Svensson, John A. Rohde, Montserrat Samso, Donald M. Bers, David D. Thomas, Razvan L. Cornea 1073-Plat 5:15 pm STRUCTURAL DYNAMICS OF CALMODULIN IN REGULATION OF CALCIUM RELEASE IN HEALTH AND DISEASE. Megan R. McCarthy , Robyn T. Rebbeck, Razvan L. Cornea, David D. Thomas 1074-Plat 5:30 pm MICROSTRUCTURAL AND FUNCTIONAL IMAGING OF THE INTACT SINOATRIAL NODE DETECTS HETEROGENOUS CA 2+ -DRIVEN INTRA AND INTERCELLULAR COMMUNICATIONS THAT LEAD TO PACING PERFECTION. Rostislav Bychkov , Kenta Tsutsui, Magdalena Juhaszova, Steven Sollott, Michael D. Stern, Victor A. Maltsev, Edward G. Lakatta 1075-Plat 5:45 pm MODULATION OF CA 2+ INFLUX AT HYPERPOLARIZED MEMBRANE PO- TENTIALS ALTERS DEPOLARIZATION-TRIGGERED EXOCYTOSIS IN BOVINE CHROMAFFIN CELLS.  Alla F. Fomina , Lukun Yang Platform Co-Chairs Shannon Yan, University of California, Berkeley Kathleen Hall, Washington University School of Medicine 1076-Plat 4:00 pm DIFFERENT CATIONS CHANGE THE RATES OF AN RNA FOLDING PATHWAY.  Robb Welty , Kathleen B. Hall 1077-Plat 4:15 pm CALCULATION OF ION-DEPENDENT RNA FOLDING FREE ENERGY USING COARSE-GRAINED SIMULATION.  Hung T. Nguyen , Dave Thirumalai RNA Structure and Dynamics 4:00 pm–6:00 pm, Esplanade, Room 155

Muscle and Motors Biophysics 4:00 pm–6:00 pm, Esplanade, Room 153

Co-Chairs Kenneth Taylor, Florida State University Richard Lieber, University of California 1060-Plat 4:00 pm

ATPASE CYCLE ANALYSIS PREDICTS THAT MUTATIONS LINKED TO DILATED CARDIOMYOPATHY IN HUMAN BETA MYOSIN WILL IMPAIR FORCE GEN-

ERATION. Michael Geeves , Zoltan Ujfalusi, Carlos Vera, Srbolujub Mijailovich, Marina Svicevic, Leslie Leinwand 1061-Plat 4:15 pm

THE ENZYMATIC ACTIVITY AND CELLULAR LOCALIZATION OF DROSOPHILA MYOSIN 7A IS REGULATED BY A NOVEL BINDING PROTEIN.  Rong Liu , Verl Siththanandan, Yi Yang, amy Hong, Fang Zhang, Xufeng Wu, Neil Billington, Yasuharu Takagi, James R. Sellers 1062-Plat 4:30 pm CHALLENGES IN TIRF-MICROSCOPY BASED SINGLE MOLECULE ATPASE AND BINDING ASSAYS FOR MYOSIN AND ACTIN.  Alf Mansson, Marko Usaj 1063-Plat 4:45 pm International Travel Awardee THE POWER OF A SYNTHETIC MACHINE BASED ON THE FAST MYOSIN ISOFORM OF SKELETAL MUSCLE.  Irene Pertici , Lorenzo Bongini, Luca Melli, Giulia Falorsi, Danut-Adrian Cojoc, Tamás Bozó, Miklós S.Z. Kellermayer, Vincenzo Lombardi, Pasquale Bianco 1064-Plat 5:00 pm MYOSIN VA VESICULAR TRANSPORT IS MODULATED BY ACTIN FILA- MENT DENSITY, ORIENTATION, AND POLARITY IN AN IN VITRO 3D ACTIN NETWORK.  Andrew T. Lombardo , Shane R. Nelson, Guy G. Kennedy, Kathleen M. Trybus, SamWalcott, David M. Warshaw 1065-Plat 5:15 pm A MINIMAL MODEL FOR THE EFFECTS OF PH AND PHOSPHATE ON MUS- CLE PROVIDES A MOLECULAR BASIS FOR CELLULAR MEASUREMENTS.  Katelyn Jarvis , Edward P. Debold, SamWalcott, Mike Woodward 1066-Plat 5:30 pm OVARIAN HORMONE AFFECTS THE REGULATION OF SUPER-RELAXATION IN SKELETAL MUSCLE.  Lien A. Phung , Sira Karvinen, Brett A. Colson, Karl J. Petersen, Dawn A. Lowe, David D. Thomas 1067-Plat 5:45 pm MECHANO-CHEMICAL COUPLING IN SARCOMERE LATTICE MODULATED BY NONLINEAR CROSSBRIDGE ELASTICITY.  Djordje Nedic , Boban Stojanovic, Michael A. Geeves, Srboljub M. Mijailovich

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