Biophysical Society 62nd Annual Meeting | Program Guide

Protein Dynamics and Allostery II (Boards B69–B89)

1146-Pos Board B55 EFFECT OF BIO-MOLECULES ON HUMAN ISLET amYLOID POLYPEPTIDE AGGREGATION, FIBRIL REMODELING AND CYTOXICITY. Yanting Xing , Feng Ding, Pu Chun Ke 1147-Pos Board B56 A PHARMACOPHORE APPROACH FOR PROTEIN INTERFACE DESIGN.  Andras Fiser 1148-Pos Board B57 BOTH CELL-ASSOCIATED AND SECRETED FORMS OF THE P. AERUGINOSA ADHESIN CDRA PROMOTE BIOFILM FORMATION. Courtney Reichhardt , Cynthis Wong, Daniel Passos da Silva, Daniel J. Wozniak, Matthew R. Parsek 1149-Pos Board B58 UNDERSTANDING THE ENDOGENOUS INHIBITION OF IAPP AGGREGA- TION. Feng Ding 1150-Pos Board B59 GLEEVEC CAN ACT AS AN ALLOSTERIC ACTIVATOR OF ABL KINASE.  Tao Xie , Tamjeed Saleh, Charalampos G. Kalodimos 1151-Pos Board B60 INTEGRATIVE STRUCTURAL BIOLOGY OF THE CALCIUM DEPENDENT TYPE 2 SECRETION PSEUDOPILUS. Aracelys Lopez-Castilla, Benjamin Bardiaux, Jenny-Lee Thomassin, Weili Zheng, Michael Nilges, Edward Egelman, Olivera Francetic, Nadia Izadi Pruneyre 1152-Pos Board B61 SELF-ASSEMBLING ABETA(30-36) PEPTIDES: A COMBINED ALL-ATOM AND COARSE-GRAINED SIMULATION STUDY. Zhenyu Qian , Qingwen Zhang, Guanghong Wei, Peijie Chen 1153-Pos Board B62 AMYLOID BETA PROTEINS MODIFIED BY PUFA OXIDATION PRODUCTS IN ALZHEIMER’S DISEASE BRAIN. Haralambos A. Mourelatos, Hiroaki Komatsu , Ran Furman, Giuseppe Grasso, Paul H. Axelsen 1154-Pos Board B63 COMPUTATIONAL STUDIES OF ALPHA-SYNUCLEIN FIBRIL FORMATION AND STABILITY. Andrew H. Beaven , Tod D. Romo, Andrew K. Lewis, An- thony R. Braun, Alan Grossfield, Jonathan N. Sachs 1155-Pos Board B64 HIV-TAT 32-62 PROTEIN FRAGMENT FORMS FIBRILLAR STRUCTURES.  Alina Popescu Hategan , Joseph Steiner, Elena Karnaukhova, Emilios K. Dimitriadis, Avindra Nath 1156-Pos Board B65 EXPLICIT SOLVENT MOLECULAR DYNAMICS SIMULATIONS OF SELF-AS- SEMBLING amYLOIDOGENIC PEPTIDES. Maksim Kouza , Andrzej Kolinski, Irina Alexandra Buhimschi, Kloczkowski Andrzej 1157-Pos Board B66 MEMBRANE INTERACTION AND ASSEMBLY MECHANISM OF AΒ IN ALZHEIMER’S DISEASE. Ya-Ling Chiang, Hsien-Shun liao, Catherine Stark, Andrew Liu, Audrey Huang, James Yao, Paul D. Smith, Curtis W. Meuse, Albert J. Jin 1158-Pos Board B67 A NEW INSIGHT INTO THE MOLECULAR MECHANISM OF THE INHIBI- TION OF LYSOZYME FIBRILLATION BY GALLIC ACID. Mouli Konar , Swagata Board B68 INVESTIGATING CURLI AND CELLULOSE INTERACTIONS IN THE SPATIAL CONTEXT OF BACTERIAL BIOFILMS. Nicolette F. Goularte , Lynette Cegel- ski Dasgupta 1159-Pos

M O N D A Y

1160-Pos Board B69 ANTIGEN PROCESSING AT THE ATOMIC LEVEL: MD SIMULATIONS OF MHCI AND ITS PEPTIDE-LOADING COMPLEX. Olivier Fisette , Sebastian Wingbermuehle, Lars Schaefer 1161-Pos Board B70 PROTEIN LOCAL CONFORMATIONS AT THE LIGHT OF A STRUCTURAL ALPHABET. Alexandre G. de Brevern 1162-Pos Board B71 ANCIENT THIOREDOXINS EVOLVED TO MODERN DAY STABILITY-FUNC- TION REQUIREMENT BY ALTERING NATIVE STATE ENSEMBLE. Tushar Modi , Jonathan Huihui, Kingshuk Ghosh, Banu Ozkan 1163-Pos Board B72 MECHANISMS OF PROTEIN-PROTEIN SLIDING: COILED COILS AS A TOOL MODEL. David Gomez , Yaakov Levy 1164-Pos Board B73 MOLECULAR BASIS FOR THE FUNCTIONALITY OF Γ-SECRETASE INFERRED FROM STRUCTURE-BASED MODELING AND DRUGGABILITY SIMULA- TIONS.  Ji Young Lee , Zhiwei Feng, Xiang-Qun (Sean) Xie, Ivet Bahar 1165-Pos Board B74 MECHANISM OF COMPLEX FORCE-DEPENDENT UNFOLDING DYNAMICS OF TITIN IMMUNOGLOBULIN DOMAIN REVEALED BY MAGNETIC TWEE- ZERS. Guohua Yuan, Wenjun Chen, Xin Zhou, Jie Yan, Hu Chen 1166-Pos Board B75 STRUCTURAL DYNAMICS IS A DETERMINANT OF THE FUNCTIONAL SIG- NIFICANCE OF MISSENSE VARIANTS. Luca Ponzoni , Ivet Bahar 1167-Pos Board B76 ATOMISTIC SIMULATIONS REVEAL A HINDERED TRANSITION OF THE B- LOOP DOMAIN OF INFLUENZA HEMAGGLUTININ. Xingcheng Lin , Jeffrey K. Noel, Qinghua Wang, Jianpeng Ma, Jose N. Onuchic 1168-Pos Board B77 DYNAMIC MODULATION OF BINDING AS A MECHANISM FOR REGULAT- ING INTERFERON SIGNALING. Hongchun Li , Nanaocha Sharma, Ignacio J. General, Joseph M. Salvino, Gideon Schreiber, Ivet Bahar 1169-Pos Board B78 A COMPARISON OF COLLECTIVE COORDINATES FOR ANALYZING PROTEIN DYNAMICS. Eric R. Beyerle , Marina Guenza 1170-Pos Board B79 INVESTIGATING PHOSPHOANTIGEN-INDUCED CONFORMATIONAL CHANGE OF BUTYROPHILIN 3A1 USING ALL-ATOMMOLECULAR DYNAM- ICS SIMULATIONS. Christopher T. Boughter , Benoît Roux, Erin J. Adams 1171-Pos Board B80 UNDERSTANDING HOW ENVIRONMENTAL PRESSURE INFLUENCES EVO- LUTION OF ENZYMES. Toshiko Ichiye 1172-Pos Board B81 ANTIGEN INDUCED DYNAMIC CONFORMATION CHANGES OF ANTIBODY TO FACILITATE RECOGNITION OF FC RECEPTORS. Jun Zhao, Ruth Nussinov, Buyong Ma 1173-Pos Board B82 LESSONS FROM 8 MILLISECONDS OF AGGREGATED KINASE MOLECULAR DYNAMICS SIMULATIONS. Mohammad M. Sultan , Vijay Pande 1174-Pos Board B83 MOLECULAR ANALYSIS OF DENGUE NS3 HELICASE FUNCTION. Kelly E. Du Pont , Russell B. Davidson, Brian J. Geiss, Martin McCullagh

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