Biophysical Society 62nd Annual Meeting | Program Guide

Calcium Signaling I (Boards B340–B355) 1431-Pos Board B340 STORE-OPERATED CALCIUM ENTRY IN ADULT WILD TYPE VENTRICLE CAR- DIOMYOCYTES. Dmitry Grekhnyov, Konstantin Gusev, Vladimir Vigont, Elena Kaznacheyeva 1433-Pos Board B342 HELIX-HELIX CONTACTS BETWEEN THE ORAI1 PORE SEGMENT AND THE TM2/3 RING REGULATES STIM1-MEDIATED CRAC CHANNEL ACTIVA- TION. Priscilla S.-W. Yeung , Megumi Yamashita, Christopher E. Ing, Régis Pomès, Douglas M. Freymann, Murali Prakriya 1432-Pos Board B341 STIM1 FUNCTION IS CONTROLLED BY MULTIPLE CA 2+ BINDING SITES IN ITS LUMINAL DOMAIN. Aparna Gudlur , Ana Eliza Zeraik, Nupura Hirve, Rajanikanth Vangipurapu, Andrey Bobkov, Guolin Ma, Sisi Zheng, Youjun Wang, Yubin Zhou, Elizabeth Komives, Patrick G. Hogan 1434-Pos Board B343 STIM PROTEINS CLUSTER ORAI1 CHANNELS AND MODULATE RECEPTOR- MEDIATED CALCIUM SIGNALS. Robert M. Nwokonko , Yandong Zhou, Xiangyu Cai, Natalia Loktionova, Mohamed Trebak, Donald L. Gill 1435-Pos Board B344 EVP4593 COMPOUND DECREASES ABNORMAL STORE-OPERATED CAL- CIUM ENTRY IN IPSCS-BASED MODEL OF HUNTINGTON’S DISEASE.  Vladimir Vigont , Konstantin Gusev, Elena Kaznacheyeva 1436-Pos Board B345 INTERPLAY OF CRAC CHANNELS WITH CA 2+ ACTIVATED K + CHANNELS.  Adela Krizova , Romana Schober, Sonja Lindinger, Carmen Butorac, Chris- toph Romanin, Isabella Derler 1437-Pos Board B346 CHARACTERIZATION OF THE CALCIUM RELEASE-ACTIVATED CALCIUM (CRAC) CHANNEL FROM THE HUMAN PATHOGEN SCHISTOSOMA MAN- SONI . Ana Eliza Zeraik , Aparna Gudlur, Ricardo DeMarco, Ana Paula U. Araujo, Patrick Hogan 1438-Pos Board B347 NO ROLE FOR ELEVATED INTRACELLULAR CALCIUM DURING MALARIA INVASION. Viola Introini , Alex J. Crick, Teresa Tiffert, Jurij Kotar, Yen-Chun Lin, Pietro Cicuta, Virgilio L. Lew 1439-Pos Board B348 EXPRESSION LEVEL OF STIM PROTEINS ALTER ELECTROPHYSIOLOGICAL PROPERTIES OF ENDOGENOUS CALCIUM CHANNELS. Alexey V. Shalygin , Dmitrii Kolesnikov, Anton Skopin, Anastasia Perevoznikova, Lyubov Glushankova, Elena V. Kaznacheyeva 1440-Pos Board B349 TUNING THE LATERAL RANGE OF L-TYPE CALCIUM CHANNEL-DEPENDENT CALCIUM SIGNALS IN DENDRITES OF HIPPOCAMPAL NEURONS.  William A. Sather , Mark L. Dell’Acqua, Philip J. Dittmer 1441-Pos Board B350 STORE-OPERATED ION CHANNELS ARE ACTIVATED AFTER CHRONIC ER STRESS IN BETA CELLS. Benjamin M. Thompson , Suryakiran Vadrevu, Leslie Satin 1442-Pos Board B351 NEW FLUORESCENT TOOLS TO IDENTIFY STRESSED CELLS AND INTERRO- GATE SECOND MESSENGER SIGNALING IN NEURODEGENERATION.  Thomas Hughes , Kevin Harlen 1443-Pos Board B352 PULSED RADIOFREQUENCY FOR CHRONIC PAIN: AN ELECTROPORATION MEDIATED CALCIUM SIGNALING PROCESS? Borja Mercadal , Rubén Vicente, Antoni Ivorra

1418-Pos Board B327 SINGLE SNARE COMPLEX RECYCLING BY NSF. Ucheor Brandon Choi , Minglei Zhao, Kristopher I. White, Qiangjun Zhou, Richard Pfuetzner, Axel

T. Brunger 1419-Pos

M O N D A Y

Board B328 DILATION OF FUSION PORES BY SYNAPTOTAGMIN-1 C2AB DO- MAINS. Zhenyong Wu, Lu Ma, Yongli Zhang, Erdem Karatekin 1420-Pos Board B329 STRUCTURAL INSIGHT INTO THE INTERACTION OF SYNAPTOTAGMIN-1 AND SNARE COMPLEX ON LIPID BILAYER BY CRYO-ELECTRON MICROS- COPY. Kirill Grushin , Jing Wang, Jeff Coleman, James E. Rothman, Charles V. Sindelar, Shyam S. Krishnakumar 1421-Pos Board B330 THE SYNAPTOTAGMIN CALCIUM-BINDING LOOPS MODULATE THE RATE OF FUSION PORE EXPANSION. Mounir Bendahmane , Kevin P. Bohannon, Tejeshwar C. Rao, Schmidtke W. Michael, Prabhodh Abbineni, Alexandra H. Ranski, Mazdak M. Bradberry, Sherleen Tran, Nara L. Chon, Jefferson D. Knight, Hai Lin, Edwin R. Chapman, Arun Anantharam 1422-Pos Board B331 STRUCTURE-BASED ENHANCEMENT OF GOSSYPIUM SYNAPTOTAGMIN TO MODIFY TOLERANCE TO ENVIRONMENTAL STRESS. Anthony A. Bui , Faraz M. Harsini, Roger Bryan Sutton 1423-Pos Board B332 OPTICAL MONITORING OF INDIVIDUAL RELEASE SITES TESTS A NEW MECHANISM FOR SYNAPTIC DEPRESSION. Hua Wen , Paul Brehm 1424-Pos Board B333 EXO- AND ENDOCYTOSIS AT A RETINAL INHIBITORY SYNAPSE DURING CROSSOVER INHIBITION. Marc A. Meadows , Margaret Veruki, Espen Hartveit, Henrique von Gersdorff 1425-Pos Board B334 SINGLE MOLECULE FLUORESCENCE STUDIES REVEAL OTOFERLIN AS A MULTIVALENT SCAFFOLD LINKING SNARES AND CALCIUM CHANNELS FOR EXOCYTOSIS AT RIBBON SYNAPSES. Colin P. Johnson , Nicole Hams, Weihong Qiu 1426-Pos Board B335 COMPARISON OF DETERMINISTIC AND STOCHASTIC APPROACHES FOR CALCIUM DEPENDENT EXOCYTOSIS. Victor Matveev 1427-Pos Board B336 THE INTERPLAY OF DOPAMINE RECEPTORS IN THE PANCREATIC ISLET REGULATES HORMONE SECRETION. Alessandro Ustione , David W. Piston 1428-Pos Board B337 ULTRASTRUCTURAL AND FUNCTIONAL ANALYSIS OF WEIBEL-PALADE BODIES. James Streetley, Ana-Violeta Fonseca, Jack Turner, Nikolai I. Kiskin, Tom Carter , Peter Rosenthal 1429-Pos Board B338 DYNAMIN-1 RESTRAINS VESICULAR CATECHOLAMINE RELEASE TO A SUB- QUANTAL MODE IN MAMMALIAN ADRENAL CHROMAFFIN CELLS. Qihui Wu, Quanfeng Zhang, Yinglin Li, Bin Liu, Xi Wu, Changhe Wang, Feipeng Zhu, Zhuan Zhou 1430-Pos Board B339 SECRETORY GRANULE LUMENAL PROTEINS HAVE HIGHLY LIMITED MO- BILITY. Prabhodh S. Abbineni , Kevin P. Bohannon, Mary A. Bittner, Daniel Axelrod, Ronald W. Holz

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