Biophysical Society 62nd Annual Meeting | Program Guide

Ligand-gated Channels II (Boards B393–B414)

1470-Pos Board B379 NORQUETIAPINE, THE ACTIVE METABOLITE OF QUETIAPINE, INHIBITS CLONED HERG POTASSIUM CHANNELS. Hong Joon Lee , Jin-Sung Choi, Sang June Hahn 1471-Pos Board B380 MOLECULAR MECHANISMS OF HERG POTASSIUM CHANNEL INTERAC- TIONS WITH IVABRADINE: IMPORTANCE OF THE LIPOPHILIC ROUTE. Ser- gei Noskov, Henry Duff, Laura Perissinotti, Jiqing Guo, Meruyert Kudaibergenova 1472-Pos Board B381 SINUSOIDAL VOLTAGE PROTOCOLS FOR RAPID CHARACTERISATION OF ION CHANNEL KINETICS. Kylie A. Beattie, Adam P. Hill, Remi Bardenet, Yi Cui, Jamie I. Vandenberg, David J. Gavaghan, Teun P. de Boer, Gary R. Mirams 1473-Pos Board B382 COMPARISON OF HERG AND ZERG POTASSIUM CHANNEL FUNCTION AND PHARMACOLOGY. Christina M. Hull , Christine E. Genge, Glen F. Tib- bits, Thomas W. Claydon 1474-Pos Board B383 DYNAMICS OF THE EAG DOMAIN AND CYCLIC NUCLEOTIDE-BINDING HOMOLOGY DOMAIN INTERACTION PROBED WITH A FLUORESCENT NONCANONICAL amINO ACID (L-ANAP) IN HERG POTASSIUM CHAN- NELS. Ashley A. Johnson , Matthew C. Trudeau 1475-Pos Board B384 CALCIUM-CALMODULIN REGULATION OF HEAG1 CHANNEL GATING IS ALSO IMPORTANT FOR THE ENHANCED PROLIFERATION OF HEAG1 EXPRESSING CELLS. Alina Finch , Raj Patel, Fred W. Muskett, John S. Mitcheson 1476-Pos Board B385 PROTEIN DEGRADATION MECHANISM OF EAG1 K + CHANNEL. Chih-Yung Tang , Po-Hao Hsu, Ya-Ching Fang, Chung-Jiuan Jeng 1477-Pos Board B386 BIOPHYSICAL CHARACTERIZATION OF A PREDICTED SHAKER SPLICE VARI- ANT WITH AN UNCONVENTIONAL INITIATION CODON. Hans J. Moldenhauer , Scarlett E. Delgado, Nieves Navarro, David Naranjo 1478-Pos Board B387 THE MONO-ADP-RIBOSYLTRANSFERASE ARTD10 REGULATES KV1.1 THROUGH PKCD. Yuemin Tian , Patricia Verheugd, Priyanka Goswami, Anand Goswami, Daniel Komnig, Bernhard Lüscher, Stefan Gründer 1479-Pos Board B388 REGION-SPECIFIC PHOSPHORYLATION OF VOLTAGE-GATED POTASSIUM CHANNEL KV2.1 IN MAMMALIAN BRAIN.  Jiyeon Hwang 1480-Pos Board B389 THE KV2.1 POTASSIUM CHANNEL FORMS ENDOPLASMIC RETICULUM/ PLASMA MEMBRANE JUNCTIONS VIA INTERACTION WITH VAP-A AND VAP-B. Benjamin T. Johnson , Ashley Leek, Michael Kirmiz, Emily Maverick, James Trimmer 1481-Pos Board B390 VOLTAGE-GATED POTASSIUM CHANNEL KV3.1B IS REGULATED BY THE SODIUM CHANNEL BETA3 SUBUNIT.  Jiseon Shim 1482-Pos Board B391 THE FUNCTIONAL MODULATION OF SODIUM-ACTIVATED POTAS- SIUM (SLACK) CHANNELS BY PHOSPHATASE AND ACTIN REGULATOR 1 (PHACTR1). Syed R. Ali , Leonard K. Kaczmarek 1483-Pos Board B392 DEVELOPMENT OF AN AUTOMATED ELECTROPHYSIOLOGY ASSAY FOR KV1.3 USING NANION SYNCROPATCH 384PE. Kaylee Choi , Joe McGivern

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1484-Pos Board B393 AGONIST-SPECIFIC PHARMACOLOGICAL EFFECTS OF CMPI AND NS9283 AT (Α4)3(Β2)2 NEURONAL NICOTINIC. ACETYLCHOLINE RECEPTORS. Kem- burli Munoz, Farah Deba, Ayman K. Hamouda 1485-Pos Board B394 EFFECTS OF CHRONIC MENTHOL AT ΑLPHA3ΒETA4 (Α3Β4)-CONTAINING NICOTINIC ACETYLCHOLINE RECEPTORS. Selvan Bavan , Suparna Pa- towary, Charlene H. Kim, Brandon J. Henderson, Henry A. Lester 1486-Pos Board B395 ANCESTRAL RECONSTRUCTION APPROACH TO ACETYLCHOLINE RECEP- TOR STRUCTURE AND FUNCTION. Corrie J. B. daCosta , Jethro E. Prinston, Johnathon R. Emlaw, Mathieu F. Dextraze, Christian J. G. Tessier, F. Javier Pérez-Areales, Melissa S. McNulty 1487-Pos Board B396 ALLOSTERIC ACTIVATION OF UNLIGANDED ACHRS: MULTIPLE, BUMPY PATHWAYS. Tapan K. Nayak , Anthony Auerbach 1488-Pos Board B397 ALTERNATIVE BINDING MODE OF FULL AND PARTIAL AGONISTS IN A PEN- TAMERIC LIGAND-GATED ION CHANNEL STABILISES LOOP C IN AN OPEN CONFORMATION. Marc A. Dämgen , Timo Greiner, Remigijus Lape, Lucia G. Sivilotti, Philip C. Biggin 1489-Pos Board B398 PHARMACOLOGICAL PROPERTIES AND EVALUATIONS OF A NOVEL POSI- TIVE ALLOSTERIC MODULATOR OF Α7 NACHR FOR ATTENUATION OF SCHIZOPHRENIA-LIKE BEHAVIOR IN MICE. Lilan Sun, Taoyi Yang, Wenxuan Jiao, Qi Sun, Kewei Wang 1490-Pos Board B399 FUNCTIONAL CHARACTERIZATION OF NOVEL PHOTO-SWITCHABLE NEU- ROMUSCULAR BLOCKERS. Clara Herrera-Arozamena , Olaia Martí-Marí, Martín Estrada, Mario Dela Fuente-Revenga, Carlos A. Villalba-Galea, María Isabel Rodríguez-Franco 1491-Pos Board B400 ENDOCYTOSIS PARTICIPATION IN NICOTINE-INDUCED UPREGULATION OF ALPHA 7 (Α7) NICOTINIC ACETYLCHOLINE RECEPTORS (NACHRS) IN XENO- PUS OOCYTES.  Joseph Farley , Jayharsh Panchal, Kristi DeBoeuf, Moham- mad Islam, Jonathan Blake Anderson, Vasu Sheel, Josh Hoffer 1492-Pos Board B401 AGONIST BINDING TO ENDPLATE ACHRS: MWC IS A-OK.  Anthony Auerbach , Tapan K. Nayak 1493-Pos Board B402 DISSECTING KINETIC DIFFERENCES IN ANCESTRAL/EXTANT HYBRID ACE- TYLCHOLINE RECEPTORS. Christian Tessier , Corrie daCosta 1494-Pos Board B403 ALLOSTERIC MODULATION OF THE PENTAMERIC LIGAND-GATED ION CHANNEL ELIC BY FUNCTIONALLY ACTIVE NANOBODIES. Marijke Brams, Hannelore De Peuter, Radovan Spurny, Els Pardon, Daniel Bertrand, Jan Steyaert, Cedric Govaerts, Chris Ulens 1495-Pos Board B404 GLYCINE RECEPTOR OLIGOMERIZATION CHARACTERIZED BY NUMBER AND BRIGHTNESS ANALYSIS. Mohammed A. Shanawaz , Sheena Mago, Allen Stekol, Mario J. Rebecchi, James P. Dilger 1496-Pos Board B405 EFFECTS OF 5-HT 3A INTRACELLULAR DOMAIN MODIFICATIONS ON OLIGO- MERIZATION. Antonia Stuebler , Michaela Jansen

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