Biophysical Society 62nd Annual Meeting | Program Guide

1522-Pos Board B431 VISCOSITY AND CONDUCTIVITY TUNABLE DIODE-LIKE BEHAVIOR FOR MESO- AND MICROPORES. Rachel A. Lucas , Yinghua Qiu, Zuzanna S. Siwy 1523-Pos Board B432 PKA-DEPENDENT PHOSPHORYLATION UNDERLIES FUNCTIONAL UPREGU- LATION OF SK CHANNELS IN VENTRICULAR MYOCYTES FROM HYPERTRO- PHIC HEARTS.  Iuliia Polina , Shanna Hamilton, Radmila Terentyeva, Karim Roder, Gideon Koren, Dmitry Terentyev 1524-Pos Board B433 EXTRACELLULAR PHOSPHATE IS AN ENDOGENOUS REGULATOR FOR VOLTAGE-GATED PROTON CHANNELS AND PRODUCTION OF REACTIVE OXYGEN SPECIES IN OSTEOCLASTS. Guangshuai Li, Katsuuki Miura, Yo- shiko Hino, Yoshie Moriura, Junko Kawawaki, Hiromu Sakai, Miyuki Kuno 1525-Pos Board B434 THE SIGMA-1 RECEPTOR MODULATES K V 1.2 CHANNELS IN THE ABSENCE OF THE K V Β2 SUBUNIT. Madelyn J. Abraham , Adrian YC Wong, Richard Board B435 EVIDENCE FOR MECHANOSENSITIVE CHANNEL ACTIVITY OF TENTONIN 3/ TMEM150C. Gyu-Sang Hong 1527-Pos Board B436 GRAMICIDIN ION BINDING AND CONDUCTANCE: NEW INSIGHTS FROM 17O SOLID STATE NMR SPECTROSCOPY IN A 1.5 GHZ SPECTROMETER.  Joana Paulino , Ivan Hung, Eduard Chekmenev, Zhehong Gan, Timothy A. Cross 1528-Pos Board B437 MODEL DEVELOPMENT OF SK CHANNEL GATING INCORPORATING CALCIUM SENSITIVITY AND DRUG INTERACTION.  Ilse van Herck , Bo H. Bentzen, Vincent Seutin, Hemenegild Arevalo, Mary M. Maleckar, Neil V. Marrion, Andrew G. Edwards 1529-Pos Board B438 ROLE OF NEURONAL JUNCTOPHILINS IN RECRUITMENT AND MODU- LATION OF VOLTAGE-GATED CALCIUM CHANNELS IN pm-ER JUNC- TIONS. Stefano Perni , Kurt G. Beam Ion Channels, Pharmacology, and Disease I (Boards B439–B461) 1530-Pos Board B439 ISTAROXIME ACCELERATES CALCIUM TRANSIENT DECAY IN HUMAN IN- DUCED PLURIPOTENT STEM CELL-DERIVED CARDIOMYOCYTES. Beatrice Badone , Roel Spatjens, Cristina Altrocchi, Paul Volders, Antonio Zaza 1531-Pos Board B440 PATIENT-SPECIFIC MUTATIONS IMPAIR BESTROPHIN1’S ESSENTIAL ROLE IN MEDIATING CA 2+ -DEPENDENT CL - CURRENTS IN HUMAN RPE. Yao Li, Yu Zhang, Yu Xu, Alec Kittredge, Nancy Ward, Shoudeng Chen, Stephen Tsang, Tingting Yang 1532-Pos Board B441 D242N, A K V 7.1 LQTS MUTATION UNCOVERS A KEY RESIDUE FOR I KS VOLT- AGE DEPENDENCE. Cristina Moreno, Anna Oliveras, Chiara Bartolucci, Carmen Mu oz, Alicia de la Cruz, Diego A. Peraza, Juan R. Gimeno, Mer- cedes Martin-Martinez, Stefano Severi, Antonio Felipe, Pier D. Lambiase, Teresa Gonzalez, Carmen Valenzuela 1533-Pos Board B442 NORMETHSUXIMIDE AND ETHOSUXIMIDE POTENTIATE Α1Β3Γ2 GABA A RECEPTORS AND ALLEVIATE PENTYLENETETRAZOL-MEDIATED INHIBITION IN CULTURED HEK293 CELLS. Brendan Ito , Yongli Chen Bergeron 1526-Pos

1534-Pos Board B443 EXPLORING THE ROLE OF RYANODINE RECEPTORS IN HUNTINGTON’S DIS- EASE PATHOPHYSIOLOGY. Panagiota Apostolou , Steven Reiken, Qi Yuan, Kaylee Wedderburn-Pugh, Felicia Benoit, Ari Moscona, Kavin Chada, AndrewMarks 1535-Pos Board B444 STRUCTURAL MODELING OF FULL-LENGTH KCA CHANNELS USING ROSET- TA. Heesung Shim , Heike Wulff, Kevin DeMarco, Vladimir Yarov-yarovoy 1536-Pos Board B445 DUAL EFFECT OF amIODARONE ON THE ONCOGENIC KV10.1 CHAN- NEL. Froylan Gomez-Lagunas , Carolina Barriga-Montoya, Areli Huanosta- Board B446 POLYPEPTIDE TOXINS: TWO NEW INHIBITORS OF THE ONCOGENIC PO- TASSIUM CHANNEL KV10.1. Enoch Luis , Erika Monserrat Torres-Moales, Arlet Loza-Huerta, Sergio Román-González, Roberto Arreguin-Espinosa, Cesar Oliver Lara-Figueroa, Arturo Hernández-Cruz, Lourival D. Possani, Arturo Picones 1538-Pos Board B447 IDENTIFICATION OF AN ETHANOL RECOGNITION SITE IN BK BETA1 SUB- UNIT THAT MEDIATES ETHANOL-INDUCED CEREBRAL ARTERY MYOCYTE BK CHANNEL INHIBITION AND THE RESULTING ARTERY CONSTRIC- TION. Guruprasad Kuntamallappanavar, Anna Bukiya, Alex Dopico 1539-Pos Board B448 INTRODUCING SIMULATED I K1 INTO HUMAN IPSC-CARDIOMYOCYTES USING DYNAMIC CLAMP ON AN AUTOMATED PATCH CLAMP PLAT- FORM. Corina Bot , Nadine Becker, Birgit Goversen, Sonja Stoelzle-Feix, Alison Obergrussberger, Toon A.B. van Veen, Niels Fertig, Teun P. de Boer 1540-Pos Board B449 CID Travel Awardee MECHANISM OF GATING OF THE INTERMEDIATE-CONDUCTANCE CAL- CIUM-ACTIVATED POTASSIUM CHANNEL (KCA3.1). Brandon M. Brown , Heesung Shim, Heike Wulff 1541-Pos Board B450 DEVELOPMENT OF K V 1.3-BLOCKING MONOCLONAL ANTIBODIES USING TETRAHYMENA THERMOPHILA . Janna Bednenko, Rian Harriman, Lore Mariën, Hai M. Nguyen , Alka Agrawal, Ashot Papoyan, Yelena Bisharyan, Joanna Cardarelli, Ted Clark, Donna Cassidy-Hanley, Bas van der Woning, Hans de Haard, Ellen Collarini, Heike Wulff, Paul Colussi 1542-Pos Board B451 FUNCTION, EXPRESSION, AND PHARMACOLOGY OF DISEASE-ASSOCIATED MUTATIONS OF NMDA RECEPTORS. Vojtech Vyklilcky , Barbora Karusova, Bohdan Kysilov, Marek Ladislav, Pavla Hubalkova, Tereza Smejkalova, Mar- tin Horak, Hana Chodounska, Eva Kudova, Jiri Cerny, Ladislav Vyklicky 1543-Pos Board B452 NOVEL DRUGS THAT AUGMENT KCNQ (KV7, “M-TYPE”) POTASSIUM CHANNELS AS A POST-EVENT TREATMENT FOR TRAUMATIC BRAIN IN- JURY.  Isamar Sanchez , Fabio Antonio Borges Vigil, Eda Bozdemir, Rafael J. Veraza, Liliana Espinoza, Deborah M. Holstein, MaryAnn Hobbs, Vladislav Bugay, James Lechleiter, Robert Brenner, Mark S. Shapiro 1544-Pos Board B453 DISEASE-ASSOCIATED MUTATIONS REVEAL A CONSERVED GLYCINE THAT STABILIZES OPPOSING CHANNEL CONFORMATIONS IN IONOTROPIC GLU- TAMATE RECEPTORS.  Johansen amin , Xiaodong Pang, Aaron Gochman, Mark E. Bowen, Huan-Xiang Zhou, Lonnie P. Wollmuth 1545-Pos Board B454 DEVELOPMENT AND APPLICATION OF A PEPTIDE INHIBITOR-BOUND QUANTUM DOT TARGETING THE VOLTAGE-GATED POTASSIUM CHAN- NEL KV1.3 IN THE OLFACTORY BULB. Austin B. Schwartz , Anshika Kapur, Zhenbo Huang, Raveendra Anangi, Zoltan Dekan, Erminia Fardone, Gou- tam Palui, Glenn F. King, Hedi Mattoussi, Debra A. Fadool Gutiérrez 1537-Pos

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