Biophysical Society 62nd Annual Meeting | Program Guide

Myosins (Boards B481–B504)

1585-Pos Board B494 VARIATION IN STRIDE LENGTH OF MYOSIN-5A REVEALED BY INTERFERO- METRIC SCATTERING MICROSCOPY (ISCAT). Joanna Andrecka, Adam Fineberg , Daniel Cole, Alistair Curd, Kavitha Thirumurugan, Yasuharu Takagi, James R. Sellers, Peter J. Knight, Philipp Kukura 1586-Pos Board B495 HIGH RESOLUTION CRYO-EM STRUCTURES OF ACTIN-BOUND MYOSIN STATES REVEAL THE MECHANISM OF MYOSIN FORCE SENSING. Ahmet Mentes , Andrew Huehn, Xueqi Liu, Adam Zwolak, Roberto Dominguez, Henry Shuman, E. Michael Ostap, Charles V. Sindelar 1587-Pos Board B496 FORCE PRODUCED BY SMOOTH AND SKELETAL MUSCLE MYOSIN FILA- MENTS MEASURED WITH MICRO-FABRICATED CANTILEVERS. Yu-Shu Cheng , Md Rezuanul Haque Saikat, Dilson Rassier 1588-Pos Board B497 CAN WE REPRODUCE THE LATCH-STATE IN VITRO AT THE MOLECULAR LEVEL? Zsombor Balassy , Linda Kachmar, Gijs Ijpma, Anne-Marie Lauzon 1589-Pos Board B498 INFLUENCE OF SAMPLE SOURCE: SLIDING VELOCITY OF DIFFERENT NATIVE THIN FILAMENTS ON TISSUE PURIFIED SLOW SKELETAL AND CAR- DIAC MYOSIN. Maral Mohebbi, Petra Uta, Theresia Kraft, Tim Scholz 1590-Pos Board B499 MEASURING THE FORCE OF SINGLE AND/OR MULTIPLE MYOSIN 5 BY US- ING A SINGLE BEAM OPTICAL TRAP.  Justin J. Raupp , Yuwen Mei, Takeshi Education Travel Awardee THE FORCE-DEPENDENT ACTIVITY OF MULTIPLE MYOSIN VI MONO- MERS. Ellen Rumley , David Altman 1592-Pos Board B501 MUTATIONS IN THE CONVERTER DOMAIN OF MYOSIN V DEMONSTRATE COUPLING BETWEEN LEVER ARM SWING AND PHOSPHATE RELEASE.  Laura K. Gunther , Shane D. Walton, Wanjian Tang, William C. Unrath, Darshan Trivedi, Christopher M. Yengo 1593-Pos Board B502 OBSERVING THE BEHAVIOR OF A SINGLE MYOSIN HEAD WITHIN A MYOSIN FILAMENT MOVING ON ACTIN. Richard Brizendine , Josh Baker, Christine Cremo 1594-Pos Board B503 ENSEMBLE BEHAVIOR OF ACTOMYOSIN CROSSBRIDGES. Khoi D. Nguyen , Madhusudhan Venkadesan 1595-Pos Board B504 FORCE AND CALCIUM REGULATION OF A SINGLE MYOSIN-5B MOTOR. Lu- cia Gardini, Sarah M. Heissler, Claudia Arbore, Yi Yang, James R. Sellers, Francesco S. Pavone, Marco Capitanio Cell Mechanics, Mechanosensing, and Motility I (Boards B505–B532) 1596-Pos Board B505 BIOPHYSICS OF MECHANOSENSITIVE CADHERIN ADHESION AND ITS REGULATION. Andrew V. Priest , Ramesh Koirala, Chi-Fu Yen, Sanjeevi Sivasankar 1597-Pos Board B506 MECHANOCHEMICAL MODELING AS AN EXPLORATIVE TOOL TO STUDY TISSUE MORPHOGENESIS. Francesco Atzeni , Richard S. Smith, Christof Aegerter, Damian Brunner Sakamoto 1591-Pos Board B500

1572-Pos Board B481 IS THE MYOSIN HEAD CONFORMATION COUPLED TO THE THICK FILA- MENT BACKBONE STRUCTURE? Kenneth A. Taylor , Zhongjun Hu, Dianne W. Taylor, Robert J. Edwards 1573-Pos Board B482 MYOSIN PHOSPHORYLATION-MEDIATED RESCUE OF CARDIAC FUNCTION IN FAMILIAL HYPERTROPHIC CARDIOMYOPATHY. Sunil Yadav , Katarzyna Kazmierczak, Jingsheng Liang, Chen-Ching Yuan, Zhiqun Zhou, Lauro Takeuchi, Rosemeire Kanashiro-Takeuchi, Danuta Szczesna-Cordary 1574-Pos Board B483 THE IMPACT OF DISEASE-RELATED MUTATIONS ON THE STRUCTURAL DYNAMICS AND ALLOSTERY IN MYOSIN MOTORS. Julia Weder, Matthias Preller 1575-Pos Board B484 IMPACT OF HYPERTROPHIC CARDIOMYOPATHY MUTATIONS AND THE ROLE OF MYOSIN BINDING PROTEIN-C ON THE SEQUESTERED STATE OF MYOSIN. Darshan V. Trivedi* , Saswata S. Sarkar*, Makenna M. Morck, Arjun A. Adhikari, Kathleen M. Ruppel, James A. Spudich 1576-Pos Board B485 A MIXED-KINETIC MODEL DESCRIBES UNLOADED VELOCITIES OF SMOOTH, SKELETAL, AND CARDIAC MUSCLE MYOSIN FILAMENTS IN VITRO. Richard Brizendine , Gabriel Sheehy, Diego Alcala, Sabrina Noven- schi, Josh Baker, Christine Cremo 1577-Pos Board B486 SINGLE MOLECULE, OPTICAL TRAPPING STUDIES OF OMECAMTIV MER- CARBIL ON HUMAN CARDIAC MYOSIN’S FORCE PRODUCTION. Michael S. Woody , Michael J. Greenberg, Bipasha Barua, Donald A. Winkelmann, Yale E. Goldman, E. Michael Ostap 1578-Pos Board B487 HYDRATION OF MAGNESIUM IS REQUIRED FOR MYOSIN VI PHOSPHATE RELEASE. Mauro L. Mugnai , Devarajan Thirumalai 1579-Pos Board B488 OPTICAL CONTROL OF FAST AND PROCESSIVE ENGINEERED MYOSINS: OPTIMIZATION AND CHARACTERIZATION IN VITRO AND IN LIVING CELLS. Paul V. Ruijgrok , Rajarshi P. Ghosh, Muneaki Nakamura, Robert Chen, Vipul Vachharajani, Jan Liphardt, Zev Bryant 1580-Pos Board B489 BIOCHEMICAL AND FUNCTIONAL CHARACTERIZATION OF THE INTERAC- TION OF MYO1C WITH 14-3-3. Huan-Hong Ji , E. Michael Ostap 1581-Pos Board B490 TOOLS TO STUDY NONMUSCLE MYOSIN-2 MOTOR FUNCTION REVIS- ITED. Sarah Heissler , Neil Billington, Xuefei Ma, Robert Adelstein, James Sellers 1582-Pos Board B491 ATPASE ACTIVITY OF DIAPHRAGMMUSCLE FIBRES ISOLATED FROM THE RABBIT CONTAINING THE R403Q MUTATION IN THE HEART. Md Rezuanul Haque Saikat , Yu-Shu Cheng, Dilson Rassier 1583-Pos Board B492 MAPPING INTRINSIC COMMUNICATION PATHWAYS IN THE MYOSIN MO- TOR DOMAIN ASSOCIATED WITH FORCE GENERATION. Wiebke Ewert , Peter Franz, Georgios Tsiavaliaris, Matthias Preller 1584-Pos Board B493 TUNING THE MECHANICAL OUTPUT OF NONMUSCLE MYOSIN-2 FILA- MENTS. Luca Melli, Neil Billington, Attila Nagy, Hajer Ennomani, Yasuhara Takagi, Laurent Blanchoin, James R. Sellers

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