Biophysical Society 63rd Annual Meeting | Program Guide

1572-Plat 4:00 pm DNA ORIGAMI-PROTEIN INTERACTIONS AND THE ROLE OF STERIC HINDRANCE.  Antonio Suma , Alex Stopar, Abimbola Adedeji, Allen W. Nicholson, Matteo Castronovo, Vincenzo Carnevale 1573-Plat 4:15 pm TAKING A CLOSER LOOK AT RECQ HELICASE WITH NANOPORE TWEEZERS. Jonathan M. Craig , K. Maria Mills, Andrew H. Laszlo, Keir C. Neuman, Jens H. Gundlach 1574-Plat 4:30 pm MOLECULAR MECHANISM OF OFF-TARGET EFFECTS IN CRISPR-CAS9.  Giulia Palermo , Clarisse Gravina Ricci, Janice S. Chen, Yinglong Miao, Martin Jinek, Jennifer A. Doudna, James A. McCammon 1575-Plat 4:45 pm TRAVEL AWARDEE SUPERCOILING MAKES PROTEIN-MEDIATED LOOPING OF DNA TETHERS DETERMINISTIC.  Yan Yan , Laura Finzi, David D. Dunlap 1576-Plat 5:00 pm TIME-RESOLVED CONTRAST VARIATION SAXS FOR STUDYING RNA-PRO- TEIN INTERACTIONS.  Suzette A. Pabit , Andrea M. Katz, George D. Calvey, Lois Pollack 1577-Plat 5:15 pm DEFECTIVE RNA INTERACTION DRIVES ABERRANT PHASE SEPARATION OF ALS-LINKED MUTANT FUS.  Amirhossein Ghanbari Niaki , Jaya Sarkar, Xinyi Cai, Sua Myong 1578-Plat 5:30 pm ROLE OF MOLECULAR CROWDING IN COMPACTING ESCHERICHIA COLI NUCLEOID.  Da Yang , Jaana Mannik, Scott T. Retterer, Jaan Mannik 1579-Plat 5:45 pm IS THE BACTERIAL CYTOPLASM A POOR SOLVENT FOR THE CHROMO- SOME?  Yingjie Xiang , Ivan Surovtsev, Eric Dufresne, Christine Jacobs- Wagner Platform Protein Structure, Prediction, Design, and Misfolding 4:00 pm - 6:00 pm, Ballroom IV Co-Chairs Ernesto Fuentes, University of Iowa Ishara Mills Henry, Framingham State University 1580-Plat 4:00 pm A PHYSICAL MODELING APPROACH TO DETERMINE PROTEIN STRUC- TURES FROM PARAMAGNETIC NMR MEASUREMENTS.  Kari Gaalswyk , Justin L. MacCallum 1581-Plat 4:15 pm BIOCHEMICAL AND STRUCTURAL CHARACTERIZATION OF DE NOVO DESIGNED PDZ DOMAINS.  Ernesto J. Fuentes , Young Joo Sun, Matthew Sternke, Vaitea Opuu, Nicholas Panel, Douglas Barrick, Thomas Simonson 1582-Plat 4:30 pm FOLDING PATHWAY OF A TWO-DOMAIN PROTEIN STUDIED WITH SINGLE MOLECULE THREE-COLOR FRET.  Ganesh N. Agam , Anders Barth, Don C. Lamb 1583-Plat 4:45 pm STABILITY AND MEMBRANE-BINDING OF SECA IN THE PRESENCE OF PO- TASSIUM GLUTAMATE, THE PRIMARY CYTOPLASMIC SALT OF ESCHERICH- IA COLI .  Guillaume Roussel, Eric Lindner, Stephen H. White

1584-Plat 5:00 pm THERMODYNAMICS OF AMINOGLYCOSIDE-ENZYME COMPLEXES YIELDS CLUES ON DISTINGUISHING THERMOPHILIC VERSUS THERMOSTABLE VARIANTS OF THE AMINOGLYCOSIDE NUCLEOTIDYLTRANSFERASE 4’ (ANT4).  Seda Kocaman , Brinda Selvaraj, Matthew Cuneo, Engin H. Serpersu 1585-Plat 5:15 pm DISULFIDE EXCHANGE AND SELF-CATALYZED AGGREGATION IN CATA- RACT-ASSOCIATED HUMAN GAMMA-D CRYSTALLIN.  Eugene Serebryany , Shuhuai Yu, Sunia A. Trauger, Bogdan Budnik, Eugene I. Shakhnovich 1586-Plat 5:30 pm TRAVEL AWARDEE HYPERSTABLE PROTEINS IN THE GUT MICROBIOTA: AN EXAMINATION OF THE BACTERIUM BACTEROIDES FRAGILIS .  Jane Thibeault , Blanca Barquera, Wilfredo Colón 1587-Plat 5:45 pm KINETIC STABILITY OF LONG-LIVED HUMAN Γ-D AND ΓS LENS CRYSTAL- LINS, DERIVED IN PART FROM THEIR DOMAIN INTERFACES, MAY PRO- TECT AGAINST CATARACT.  Ishara Mills Henry , Melissa Kosinski-Collins, Shannon Thol, Eugene Serebryany, Jonathan A. King Platform Member Organized Session: Multiscale Modeling of Biophysical Systems 4:00 pm - 6:00 pm, Room 307/308 Co-Chairs Judy Cannon, University of NewMexico Denis Tsygankov, Georgia Institute of Technology 1588-Plat 4:00 pm A MACRO-MICRO MODELING APPROACH TO DETERMINE IN-SITU HEART VALVE INTERSTITIAL CELL CONTRACTILE BEHAVIORS IN NATIVE AND SYNTHETIC ENVIRONMENTS. Michael S. Sacks 1589-Plat 4:15 pm MULTISCALE MODELING OF THE DAMAGE BIOMECHANICS OF TRAU- MATIC BRAIN INJURY.  Amir H. Bakhtiarydavijani, Michael A. Murphy, Sungkwang Mun, Mike D. Jones, M. F. Horstemeyer, Raj K. Prabhu 1590-Plat 4:30 pm MODELING T CELL MOTION IN TISSUES DURING IMMUNE RESPONSES.  Judy L. Cannon , Melanie E. Moses, Janie R. Byrum, Paulus Mrass, G. Mat- thew Fricke, Humayra Tasnim 1591-Plat 4:45 pm TRAVEL AWARDEE MULTISCALE MODELING OF DUCTAL CARCINOMA IN SITU.  Joseph D. Butner, Vittorio Cristini, Zhihui Wang 1592-Plat 5:00 pm MULTI-SCALE MODELS OF DEFORMATION OF BLOOD CLOTS. Mark Alber , Shixin Xu, Zhiliang Xu, Oleg Kim, Samuel Britton, Rustem Litvinov, John Weisel 1593-Plat 5:15 pm MULTISCALE MODELING OF THE HUMAN BLOOD PROTEIN VON WILLE- BRAND FACTOR.  Edmund B. Webb , Chuqiao Dong, Sagar Kania, Michael Morabito, Yi Wang, Xuanhong Cheng, Xiaohui Zhang, Alp Oztekin 1594-Plat 5:30 pm SOME PROSPECTS FOR ARTIFICIAL INTELLIGENCE (BOTH NUMERIC AND SYMBOLIC) IN MULTISCALE BIOPHYSICS.  Eric Mjolsness , Oliver K. Ernst, Thomas M. Bartol, Terrence J. Sejnowski 1595-Plat 5:45 pm MULTI-SCALE IMAGING TO ENABLE MULTI-SCALE MODELING FOR PREDICTING TUMOR GROWTH AND TREATMENT RESPONSE.  Thomas Yankeelov, David Hormuth , Angela Jarrett, Ernesto Lima, Chengyue Wu, Ryan Woodall, Caleb Philips

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