Biophysical Society 63rd Annual Meeting | Program Guide

1665-Pos Board B28 PROTEIN STRUCTURAL FLUCTUATIONS AT CRITICALITY IN THE TEMPERA- TURE-PRESSURE-CROWDING FOLDING PHASE DIAGRAM PROTEIN STRUC- TURAL FLUCTUATIONS AT CRITICALITY IN THE TEMPERATURE-PRESSURE- CROWDING FOLDING PHASE DIAGRAM. Margaret S. Cheung , Andrei G. Gasic, Caleb Daugherty 1666-Pos Board B29 INCREASE IN SOLUBILITY OF MONOCLONAL ANTIBODIES - FORMULATION PERSPECTIVE AND THE “MAGIC” OF ARGININE. Slobodanka D. Manceva , Amy L. Chamberlain, Rahul Ragunathan, Hsing-Ho (Vasha) Hsu, Elihu Ihms, Lisa Kueltzo, Kc Cheng, Frank Arnold 1667-Pos Board B30 EFFECTS OF HYDROSTATIC PRESSURE ON A PUTATIVE PIEZOPHILIC HOMOLOGUE OF STAPHYLOCOCCAL NUCLEASE BY FLUORESCENCE AND HIGH-PRESSURE NMR. Kacey Kilpatrick , Grayson Gerlich, Catherine A. Royer 1668-Pos Board B31 A MUTAGENESIS STUDY TO INVESTIGATE THE ROLE OF ALANINE TO SER- INE MUTATIONS IN THE ADAPTATION OF A DIATOM CYTOCHROME C 6 TO COLD TEMPERATURES. Miranda Wilson , Jordyn Preusker, Inaara Bhola, Katherine Frato 1669-Pos Board B32 PREDICTING THE STABILITY OF MONOCLONAL ANTIBODIES AT HIGH CONCENTRATION FORMULATIONS. Kylie M. Konrath , Sean Nugent, Amy L. Chamberlain, Rahul Ragunathan, Vasha Hsu, Hairong Wang, Marianna L. Fleischman, Elihu Ihms, Rajoshi Chaudhuri, Slobodanka M. Mančeva, Lisa A. Kueltzo, KC Cheng, Frank Arnold 1670-Pos Board B33 A DECOY FOLDING NUCLEUS CAN MODULATE PROTEIN FOLDING KINET- ICS. Anirban Das , Anju Yadav, Mona Gupta, Purushotham R, Vishram L. Terse, Shachi Gosavi, Ranabir Das, Sri Rama Koti Ainavarapu, Sudipta Maiti 1671-Pos Board B34 INTERPLAY BETWEEN NATIVE STATE TOPOLOGY AND SEQUENCE IN TWO- STATE PROTEIN FOLDING. Stefan Wallin , Daniel Trotter 1672-Pos Board B35 STRUCTURAL CHARACTERIZATION OF A UBIQUITIN FOLDING INTERMEDI- ATE BY PRESSURE-JUMP NMR.  Joseph M. Courtney , Cyril Charlier, Ad Bax 1673-Pos Board B36 INTERFACES OF THE TOPOISOMERASE V (HHH) 2 DOMAINS HAVE SURPRIS- ING CONTRIBUTIONS TO THERMODYNAMIC STABILITY. Mark Petersen , Rebecca Fang, Ananya Majumdar, Doug Barrick 1674-Pos Board B37 UNRAVELLING THE ROLE OF S100A9 IN THE DEVELOPMENT OF NEURO- DEGENERATIVE DISEASE. Philip T.F. Williamson , Jack Horrocks, Luckshi Maheswaran, Maria Concistre, Ludmilla Morozova-Roche 1675-Pos Board B38 EFFECT OF HSP70 CHAPERONE ON CNG ION CHANNELS RELATED TO CHANNELOPATHIES. Karina Juárez , Angelica Lopez-Rodriguez, Ivan Meneses-Morales 1676-Pos Board B39 INNOVATION OF A NOVEL PULSE-CHASE IN CELL FOOTPRINTING METHOD FOR THE STUDY OF PROTEIN FOLDING PHENOMENA. Danté T. Johnson , Benjamin Punshon-Smith, Anne Gershenson, Lisa M. Jones 1677-Pos Board B40 MONITORING PROTEIN FOLDING ON AND OFF THE RIBOSOME USING X- RAY FOOTPRINTING MASS SPECTROMETRY. Shawn M. Costello , Natalie R. Dall, Avi J. Samelson, Sayan Gupta, Corie Y. Ralston, Susan Marqusee

1678-Pos Board B41 COCHAPERONES ENABLE HSP70 TO USE ATP ENERGY FOR NON-EQUILIB- RIUM STABILIZATION OF NATIVE PROTEINS. Huafeng Xu Protein Dynamics and Allostery I (Boards B42 - B72) 1679-Pos Board B42 DESCRIPTION OF STRUCTURAL CHANGES BY MOTION TREE. Ryotaro Koike , Kei Moritsugu, Motonori Ota 1680-Pos Board B43 SIMULATING THE FOLDING TRAJECTORIES OF LATTICE PROTEINS WITHIN AN OSCILLATORY ENVIRONMENT. Xuanye Zhu , Qizhang Jia, Kateri H. DuBay 1681-Pos Board B44 TRAVEL AWARDEE UNFOLDING TRANSITIONS AND INTERDOMAIN COUPLING IN HUMAN DYSTROPHIN SPECTRIN REPEATS. Lisa Ito, Madison Nohner 1682-Pos Board B45 DRUG RESISTANCE INDUCED BY LOCAL AND ALLOSTERIC CONFORMA- TIONAL CHANGES IN ONCOGENIC TYROSINE KINASES. Mitsugu Araki , Yasushi Okuno 1683-Pos Board B46 HYDROGEN EXCHANGE REVEALS THE MECHANISM OF STABILIZATION OF P53 RESCUE MUTANTS N235K AND N239Y. Melanie J. Cocco , Jenaro Soto, Ali Alhoshani, Colleen Moody 1684-Pos Board B47 NOVEL REGULATORY MECHANISMS IDENTIFIED IN VIRAL DNA PACKAG- ING PROTEINS USING MOLECULAR DYNAMICS SIMULATIONS.  Joshua Pajak , Gaurav Arya 1685-Pos Board B48 UNVEILING A NEW REGULATION MECHANISM OF SMALL GTPASES ON THE ACTIVITY OF PLEXIN-B1 MEMBRANE RECEPTOR. Zhenlu Li , Matthias Buck 1686-Pos Board B49 WHAT MODULATES THE USP7 FUNCTION...A DYNAMIC POCKET OR INTER-REGULATORY DOMAINS? Mitul Srivastava , Charu Suri, Shailendra Asthana 1687-Pos Board B50 ALLOSTERIC EFFECTS AND SIGNAL TRANSDUCTION IN THE PEPTIDE-MHC BINDING TO A HUMAN T CELL RECEPTOR. Buyong Ma , John P. Orban, Roy Mariuzza, Ruth Nussinov 1688-Pos Board B51 THE MECHANISM OF PI3KΑ ACTIVATION AT THE ATOMIC LEVEL.  Mingzhen Zhang , Hyunbum Jang, Ruth Nussinov 1689-Pos Board B52 EXAMINATION OF ALLOSTERIC PATHWAYS IN MODEL PROTEINS USING INFORMATION-THEORETIC AND SIMULATION METHODS: REGULATORY MECHANISM OF THE KIX AND PDZ DOMAINS. Cyprian Kleist , Jacek Czub, Michal Olewniczak, Karol Jacek, Michał Jurkowski, Michał Badocha 1690-Pos Board B53 ESTIMATING THE HIGH DIMENSIONAL RUGGEDNESS OF PROTEIN FREE ENERGY LANDSCAPES FROMMOLECULAR DYNAMICS TRAJECTORIES.  Andreas Volkhardt , Helmut Grubmueller 1691-Pos Board B54 TRAVEL AWARDEE HIGH BANDWIDTH SENSING OF SINGLE PROTEIN DYNAMICS USING NANOPORES AND DNA ORIGAMI. Sonja Schmid , Pierre Stoemmer, Hen- drik Dietz, Cees Dekker

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