Biophysical Society 63rd Annual Meeting | Program Guide

2079-Pos TRAVEL AWARDEE METABOLIC-RESPONSE ASSESSMENT OF MURINE BREAST CANCER CELLS IN 2D AND 3D CULTURES USING TWO-PHOTON FLUORESCENCE LIFETIME IMAGING MICROSCOPY OF INTRINSIC NAD(P)H. Anh Cong , Rafaela Ma- rocci Lima Pimenta, VenkatramMereddy, Jon M. Holy, Ahmed A. Heikal 2080-Pos Board B443 CHARACTERIZATION OF THE METABOLIC STATE AND MOLECULAR CROWDING IN BREAST CANCER SPHEROIDS. Giulia Tedeschi , Lorenzo Scipioni, Andrew Trinh, Karina A. Lee, Leonel Malacrida, Michelle A. Dig- man, Enrico Gratton 2081-Pos Board B444 CAN VIRAL GEOMETRY DETERMINE B CELL SELECTION DURING AN IM- MUNE RESPONSE? Assaf Amitai , Arup Chakraborty, Mehran Kardar 2082-Pos Board B445 HERITABILITY AND STOCHASTICITY IN PRIMARY ENDOTHELIAL CELL SIGNALING. Christina Kim, Gregory Seedorf, Steven Abman, Douglas P. Board B446 CELL FATE DECISION BY AN ADAPTABLE MOLECULAR TIMER OF P53.  Xiaopeng Zhang 2084-Pos Board B447 PREDICTING CANDIDATE ONCO-GENESIS MUTATIONS AND COOPERATIVE UNITS FROM COMPUTED PROTEIN SURFACE POCKETS. Xue Lei , Wei Tian, Alan Perez-Rathke, Boshen Wang, Chia-Yi Chou, Jeffrey Tseng, Jie Liang 2085-Pos Board B448 THE ROLE OF MYOFIBROBLAST SENESCENCE IN ARRHYTHMOGENESIS OF THE AGED INFARCTED HEART. Brett Baggett , Kevin Murphy, Yueming Cao, Nilufer Turan, YiChun Lu, Lorraine Schofield, Tae Yun Kim, Dmitry Terentyev, Bum Rak Choi, John Sedivy, Gideon Koren 2086-Pos Board B449 DEVELOPMENT OF AN INTEGRATED HUMAN MODEL OF ELECTROPHYSI- OLOGY AND ACTIN-MYOSIN BINDING TO DESCRIBE SARCOMERE FORCE GENERATION IN CARDIOMYOCYTES. Ruth E. Abrams , Hans-Christoph Schneider, Tatiana Radziun, Britta Goebel, Laurence Lucats, Karim Azer, Howard Surks, Eric Sobie, Spyros Stamatelos 2087-Pos Board B450 INVESTIGATING THE BENEFICIAL EFFECTS OF VOLUNTARY EXERCISE IN RATS WITH PULMONARY ARTERY HYPERTENSION. Eleftheria Pervolaraki , Ed White, Al Benson 2088-Pos Board B451 INTRICATE LINK BETWEEN AUTOPHAGY AND AMYLOID-Β KINETICS: MOD- ELING AND SIMULATIONS. Kyungreem Han, Soon Ho Kim, MooYoung Choi 2089-Pos Board B452 TRAVEL AWARDEE EFFECTS OF IBUPROFEN ON MICE LIVER PROTEASOME. Rasheed Sule 2090-Pos Board B453 MODELING THE IMPACT OF POINT MUTATIONS ON THE REGULATORY POTENCY OF THE SMALL RNA SGRS. Troy A. Brier , David Bianchi, Anustup Poddar, Muhammad S. Azam, Carin K. Vanderpool, Taekjip Ha, Zaida Luthey-Schulten 2091-Pos Board B454 STRUCTURE-BASED METHOD FOR PREDICTING DELETERIOUS MISSENSE SNPS. Boshen Wang , Xue Lei, Wei Tian, Alan Perez-Rathke, Yanyuan Tseng, Jie Liang 2092-Pos Board B455 CYTOTOXICITY OF VARIOUS GOLD NANOPARTICLES - AN IN VITRO STUDY. Marika Musielak , Karolina Rucińska, Joanna Maksim, Agnieszka Bos-Liedke, Maciej Kozak Board B442 Shepherd 2083-Pos

2067-Pos Board B430 PERFORMANCE OF A BACTERIUM AS AN ENERGY CONVERSION DEVICE IN TERMS OF ENERGY-RETURN-ON-INVESTMENT DETERMINED FROM ATOMIC-DETAIL STRUCTURAL MODELS. Melih Sener , Andrew Hitchcock, Neil Hunter 2068-Pos Board B431 ENERGETIC MODELLING OF MITOCHONDRIAL REDOX REACTIONS. Peter J. Gawthrop , Edmund J. Crampin 2069-Pos Board B432 UNVEILING THE RATE-LIMITING STEP OF THE BC​ 1 ​COMPLEX REACTION MECHANISM. Angela M. Barragan , Alexander V. Soudackov, Zaida Luthey- Schulten, Klaus Schulten, Sharon Hammes-Schiffer, Ilia Solov’yov 2070-Pos Board B433 TRAVEL AWARDEE ELUCIDATING THE ROLE OF ZINC-BACTERIOCHLOROPHYLL A ’ IN THE PRIMARY PHOTOCHEMISTRY OF CHLOROACIDOBACTERIUM THERMOPHI- LUM REACTION CENTERS. Philip Charles , Vidmantas Kalendra, Zhihui He, Vasily Khurshov, Art van der Est, John H. Golbeck, Donald A. Bryant, K. V. Lakshmi 2071-Pos Board B434 THE REVERSIBLE OPENING OF SC MUC DEMONSTRATES A HIGH POTENTIAL AS A CELLULAR PROTECTION SYSTEM. Lilia Morales-García , Salvador Uribe-Carvajal, Natalia Chiquete-Felix, Emilio Espinoza -Simon Systems Biology and Disease (Boards B435 - B455) 2072-Pos Board B435 MODELING OF PROTEIN COMPLEX ARCHITECTURES USING COMBINATO- RIAL GENETIC PERTURBATIONS.  Ignacia Echeverria , Hannes Braberg, Peter Cimermancic, Riccardo Pellarin, Dina Schneidman, Anthony Shiver, Carol Gross, Nevan Krogan, Andrej Sali 2073-Pos Board B436 BONDGRAPHTOOLS: MODELLING NETWORK BIOENERGETICS. Peter Cudmore , Edmund J. Crampin 2074-Pos Board B437 A THERMODYNAMIC FRAMEWORK FOR MODELLING MEMBRANE TRANSPORTERS. Michael Pan , Peter J. Gawthrop, Kenneth Tran, Joseph Cursons, Edmund J. Crampin 2075-Pos Board B438 A COMPUTATIONAL FRAMEWORK FOR PREFERENTIAL SWITCHING OF COMPETING AΒ AGGREGATION PATHWAYS BASED ON GAME THEORY APPROACH. Pratip Rana, Jhinuk Saha, Edward Steen, Ashwin Vaidya, Vijay Rangachari, Preetam Ghosh 2076-Pos Board B439 DISCRETE AND CONTINUOUS MODELS OF PROBABILITY FLUX ON SWITCHING DYNAMICS: A CASE STUDY OF THE TOGGLE-SWITCH SYS- TEM. Anna Terebus , Chun Liu, Jie Liang 2077-Pos Board B440 FUNCTIONAL INTERPRETATION OF SINGLE AMINO ACID SUBSTITUTIONS IN 1,330 DISEASE-ASSOCIATED GENES. Sumaiya Iqbal , Jakob Berg Jespers- en, Eduardo Perez-Palma, Patrick May, Aarno Palotie, Jeffrey R. Cottrell, Florence F. Wagner, Mark J. Daly, Arthur J. Campbell, Dennis Lal 2078-Pos Board B441 THE STEADY STATE CONCENTRATION OF DIFFERENT BIOMARKERS OF OXI- DATIVE STRESS REFLECT DIFFERENT TYPES OF OXIDATIVE STRESS-. Dov A. Lichtenberg , Ilya Pinchuk, Tilman Grune, Daniela Weber

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