Biophysical Society 63rd Annual Meeting | Program Guide

Platform Cardiac Muscle Mechanics, Structure, and Regulation II 1:00 pm - 3:00 pm, Room 309/310 Co-Chairs Matthew Caporizzo, University of Pennsylvania Osha Roopnarine, University of Minnesota Medical School 2305-Plat 1:00 pm STRETCH-INDUCED ACTIVATION OF THE MYOSIN MOTORS ON THE THICK FILAMENT IN RAT CARDIAC TRABECULAE.  So-Jin Park-Holohan, Elisabetta Brunello, Thomas Kampourakis, Martin Rees, Malcolm Irving, Luca Fusi 2306-Plat 1:15 pm CARDIOMYOPATHY MUTATION AT END-END OVERLAP OF ALPHA - TROPOMYOSIN INFLUENCES COOPERATIVE ACTIVATION AND CALCIUM SENSITIVITY.  SaiLavanyaa Sundar , Michael J. Rynkiewicz, William Lehman, Jeffrey R. Moore 2307-Plat 1:30 pm ENHANCED CROSSBRIDGE BINDING WITH 2-DEOXY-ATP RESULTS FROM INCREASED ELECTROSTATIC INTERACTIONS BETWEEN MYOSIN AND AC- TIN IN CARDIAC MUSCLE.  Chen-Ching Yuan , Joseph D. Powers, Kimberly J. McCabe, Jason D. Murray, Morhan Saffie, Castillo Romi, Zuzek Carla, Weikang Ma, Andrew D. McCulloch, Thomas C. Irving, Michael Regnier 2308-Plat 1:45 pm BASIC AMINO ACIDS WITHIN THE C-TERMINAL 16 RESIDUES OF TRO- PONIN T MODULATE CALCIUM SENSITIVITY AND THE DISTRIBUTION OF ACTIN STATES.  Dylan Johnson , Li Zhu, Joseph M. Chalovich 2309-Plat 2:00 pm ON THE FUNCTIONAL ASSESSMENT OF HYPERTROPHIC CARDIOMYOP- ATHY-CAUSING MUTATIONS IN HUMAN Β-CARDIAC MYOSIN AND THE ROLE OF MYOSIN BINDING PROTEIN-C.  Darshan V. Trivedi , Saswata S. Sarkar, Arjun S. Adhikari, Makenna M. Morck, Kristina B. Kooiker, Daniel Bernstein, Kathleen M. Ruppel, James A. Spudich 2310-Plat 2:15 pm DEVELOPMENT OF AN IMAGING PIPELINE TO MODEL AND PREDICT THE INTEGRATED LOCALIZATION OF ORGANELLES IN HIPSC-DERIVED CARDIO- MYOCYTES. Melissa Hendershott , Susanne Rafelski 2311-Plat 2:30 pm DEFINING A UNIFYING MECHANISM FOR SELECT CARDIOMYOPATHY- LINKED VARIANTS OF DESMOPLAKIN.  Heather R. Manring , Ronald Ng, Taylor Albertelli, Trevor Dew, Tyler L. Stevens, Ahmet Kilic, Paul M. L. Jans- sen, Nathan T. Wright, Stuart Campbell, Maegen A. Ackermann 2312-Plat 2:45 pm DETERMINING THE IN VIVO ROLE OF MICROTUBULE DETYROSINATION IN HEALTHY AND DISEASED MYOCARDIUM.  Christina Yingxian Chen , Matthew A. Caporizzo, Kenneth Bedi, Michael P. Morley, Kenneth B. Margulies, Benjamin L. Prosser

Platform Protein-Nucleic Acid Interactions/Chromatin and the Nucleoid II 1:00 pm - 3:00 pm, Room 314/315 Co-Chairs Roberto Galletto, Washignton University School of Medicine Kelsey Bettridge, Johns Hopkins School of Medicine 2313-Plat 1:00 pm SHELTERIN COMPONENTS MODULATE THE PHASE-SEPARATION PROPEN- SITY OF TELOMERES.  Andrea Soranno, Jeremias Incicco, Paolo De Bona, Eric Tomko, Eric Galburt, Roberto Galletto 2314-Plat 1:15 pm RNA BINDING MODE REGULATES PKR ACTIVATION.  Stephen J. Hesler, Bushra Husain, Matthew Angeliadis, James L. Cole 2315-Plat 1:30 pm A SINGLE-MOLECULE INTERACTION SPECTRUM FOR NON-COVALENT IN- TERACTION INSIDE MEMBRANE PROTEIN CHANNEL. Meng-Yin Li , Yi-Lun Ying, Wei Tong, Yong-Jing Wan, Yi-Tao Long 2316-Plat 1:45 pm DISORDERED RNA CHAPERONES ENHANCE NUCLEIC ACID FOLDING VIA LOCAL CHARGE SCREENING.  Erik D. Holmstrom , Zhaowei Liu, Daniel Net- tels, Robert B. Best, Benjamin Schuler 2317-Plat 2:00 pm EUKARYOTIC TRANSCRIPTION FACTORS CAN TRACK AND CONTROL THEIR TARGET GENES USING DNA ANTENNAS.  Victor Munoz 2318-Plat 2:15 pm MULTIPLE INTERACTION MODES OF THE NUCLEOSOMAL HISTONE H3 N- TERMINAL TAIL REVEALED BY HIGH PRECISION SINGLE-MOLECULE FRET.  Kathrin Lehmann , Suren Felekyan, Ralf Kühnemuth, Mykola Dimura, Katalin Tóth, Claus A. M. Seidel 2319-Plat 2:30 pm YEAST PIONEERING TRANSCRIPTION FACTORS RELY ON SLOWED DIS- SOCIATION KINETICS TO EFFICIENTLY TARGET NUCLEOSOMAL SITES.  Benjamin T. Donovan , Hengye Chen, Caroline Jipa, Chao Yan, Lu Bai, Michael G. Poirier 2320-Plat 2:45 pm ROLE OF RNA-BINDING ACTIVITY OF HU IN CHROMOSOMAL ORGANIZA- TION.  Kelsey E. Bettridge , Xiaoli Weng, Subhash Verma, Sankar Adhya, Jie Xiao Platform Member Organized Session: Integrative Structural Modeling Using Information from Spectroscopic Labels 1:00 pm - 3:00 pm, Room 316/317 Co-Chairs Hugo Sanabria, Clemson University Claus Seidel, Heinrich Heine University, Germany 2321-Plat 1:00 pm SINGLE MOLECULE FRET - A MULTI-ENVIRONMENT RULER FOR DETER- MINING STRUCTURE AND DYNAMICS.  Bjorn Hellenkamp 2322-Plat 1:15 pm PROBING STRUCTURAL STATES IN FAST EXCHANGING PROTEINS BY FRET AND COMPUTATIONAL METHODS.  Hugo Sanabria

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