Biophysical Society 63rd Annual Meeting | Program Guide

Voltage-gated K Channels II (Boards B344 - B368)

2685-Pos Board B357 USING CLICK CHEMISTRY AND VOLTAGE CLAMP FLUORIMETRY TO STUDY STRUCTURAL DYNAMICS OF MEMBRANE PROTEINS. Kanchan Gupta , Gilman E. S. Toombes, Kenton J. Swartz 2686-Pos Board B358 STRUCTURE OF THE INTERMEDIATE STATE OF THE HUMAN KCNQ1 CHANNEL VOLTAGE-SENSOR DOMAIN. Keenan C. Taylor, Po wei Kang , Panpan Hou, Nien-Du Yang, Georg Kuenze, Jingyi Shi, Jarrod A. Smith, Kelli McFarland White, Hui Huang, Dungeng Peng, Alfred L. George Jr., Jens Meiler, Robert L. McFeeters, Jianmin Cui, Charles R. Sanders 2687-Pos Board B359 DYNAMICS OF THE PAS DOMAIN AND CYCLIC NUCLEOTIDE-BINDING HOMOLOGY DOMAIN INTERACTION PROBED WITH A FLUORESCENT NONCANONICAL AMINO ACID (L-ANAP) IN HERG POTASSIUM CHAN- NELS. Ashley A. Johnson , Matt C. Trudeau 2688-Pos Board B360 CP1 IS A POTENT I KS CHANNEL ACTIVATOR WHICH ACTS BY SUBSTITUT- ING PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE. Yongfeng Liu , Xianjin Xu, Moawiah M. Naffaa, Hongwu Liang, Guohui Zhang, Panpan Hou, Hongzhan Wang, Junyuan Gao, Jingyi Shi, Ira Cohen, Xiaoqin Zou, Jian- min Cui 2689-Pos Board B361 SINGLE CHANNEL STUDIES OF THE CATION PERMEATION PATHWAY OF THE SHAKER KV ISOLATED VOLTAGE-SENSING DOMAIN (IVSD).  Juan Zhao , Rikard Blunck 2690-Pos Board B362 DECOUPLING BETWEEN VOLTAGE SENSOR MOVEMENT AND PORE OPENING OF KV2.1 CHANNELS. Matthew J. Marquis , Rebecka J. Sepela, Board B363 MECHANISM OF BK CHANNEL INHIBITION BY THE OPIOID AGONIST LOPERAMIDE. Alexandre G. Vouga , Michael E. Rockman, Marlene A. Jacobson, Brad S. Rothberg 2692-Pos Board B364 MODULATION OF KV1.3 BY THE GUT PEPTIDE GLUCAGON-LIKE PEPTIDE 1. Daniel R. Landi Conde , Genevieve A. Bell, Debra A. Fadool 2693-Pos Board B365 CONSERVED RESIDUES AT THE INTERFACE BETWEEN THE S4 AND S5 SEGMENTS ARE CRITICAL FOR NORMAL GATING OF HCN CHANNELS.  Rosamary Ramentol , Marta E. Perez, H. Peter Larsson 2694-Pos Board B366 ENDOCANNABINOIDS FACILITATE THE OPENING OF THE M-CHANNEL.  Johan E. Larsson , Liin Sara 2695-Pos Board B367 A STRUCTURAL MODEL OF FAST INACTIVATION IN SHAKER K V CHAN- NELS. Miguel Holmgren , Ariela Vergara-Jaque, Horacio Poblete, Francisco Palma, Adam S. Lowet, Angel de la Cruz Ladrau, Alexander Sukharev, Jeffrey Comer 2696-Pos Board B368 ELECTROPHYSIOLOGICAL AND PHARMACOLOGICAL CHARACTERIZATION OF A NOVEL AND POTENT NEURONAL KV7 OPENER SCR2682 FOR ANTI- EPILEPSY. Yani Liu , Fan Zhang, Bo Liang, huangming Chen, Hailin Zhang, KeWei Wang Jon T. Sack 2691-Pos

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2672-Pos Board B344 DETERMINING FUNCTIONAL KCNQ1/KCNE1 SUBUNIT INTERACTIONS IN THE KCNQ1/KCNE1 CHANNEL. Xiaoan Wu , Marta E. Perez, Kevin J. Sampson, Robert S. Kass, Peter H. Larsson 2673-Pos Board B345 CONFORMATIONAL DYNAMICS OF THE INTRINSIC LIGAND IN THE CNBHD OF THE VOLTAGE-GATED POTASSIUM CHANNEL HERG. Sara J. Codding 2674-Pos Board B346 DIFFERENTIAL SENSITIVITY OF CARDIAC ION CHANNELS TO POLYUN- SATURATED FATTY ACID ANALOGUES. Briana Bohannon , Sara I. Liin, Peter Larsson 2675-Pos Board B347 RE-EDUCATION OF TUMOR ASSOCIATED MACROPHAGES BY TRABECT- EDIN. Diego A. Peraza , Ana B. Garcia-Redondo, Adrian Povo-Retana, Sara Arias, Ana M. Briones, Lisardo Boscá, Carlos M. Galmarini, Carmen Valenzuela 2676-Pos Board B348 TWO-PRONGED AROMATIC ARGININE-MIMICS AS HV1 PROTON CHAN- NEL INHIBITORS. Chang Zhao , Liang Hong, Jason D. Galpin, Christopher A. Ahern, Francesco Tombola 2677-Pos Board B349 PHARMACOLOGICAL MODULATION OF KV3 POTASSIUM CURRENTS.  Nadia Pilati , Michele Speggiorin, Giuseppe Alvaro, Charles H. Large 2678-Pos Board B350 EPR SPECTROSCOPIC STUDIES OF THE VOLTAGE SENSOR DOMAIN (Q1-VSD) OF HUMAN KCNQ1 POTASSIUM ION CHANNEL IN LIPID BILAY- ERS. Gunjan Dixit 2679-Pos Board B351 EFFECT OF LIPOPHILIC MOLECULES ON EPILEPSY-CAUSING MUTATIONS OF NEURONAL KCNQ CHANNELS. Ludwig Andersson, Marta E. Perez, Sara I. Liin, Fredrik Elinder, Peter H. Larsson, Rene Barro-Soria 2680-Pos Board B352 PKC ACTIVATION DECREASES KV1.5 PROTEIN EXPRESSION THROUGH ACCELERATING ENDOCYTIC CHANNEL DEGRADATION. Tingzhong Wang , Yuan Du, Jun Guo, Wentao Li, Tonghua Yang, Shetuan Zhang 2681-Pos Board B353 IDENTIFYING COMMON STRUCTURAL FEATURES FOR ELECTROME- CHANICAL COUPLING BETWEEN DOMAIN-SWAPPED AND NON- DOMAIN SWAPPED POTASSIUM CHANNELS. Ana I. Fernández-Mariño , Kenton J. Swartz 2682-Pos Board B354 CAVEOLAR KV1.3 TARGETING PARTICIPATES IN THE ADIPOCYTE PHYSIOL- OGY. Mireia Perez-Verdaguer, Jesusa CCapera Aragones, Maria Ortego- Dominguez, Joanna Bielanska, Núria Comes, Rafael J. Montoro, Marta Camps, Antonio Felipe 2683-Pos Board B355 DEVELOPMENT OF BK CHANNEL AGONISTS AND ANTAGONISTS THAT TARGET A COMMON RECOGNITION AREA IN THE ACCESSORY BETA1 SUBUNIT. Anna N. Bukiya, Guruprasad Kuntamallappanavar, Abby L. Parrill, Alex M. Dopico 2684-Pos Board B356 PROTEOMICS ANALYSIS POINTS AT NOVEL CELLULAR PARTNERS FOR THE KCNMB1 PROTEIN PRODUCT. Kelsey North, David Kakhniashvili, Alex M. Dopico, Anna N. Bukiya

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