Biophysical Society 63rd Annual Meeting | Program Guide

Friday, March 1 Exhibitor Registration 8:00 am - 5:00 pm, Charles Street Lobby Drug Discovery for Ion Channels XIX Satellite Meeting 8:00 am - 5:00 pm, Room 303

12:45 pm

LUNCH (PROVIDED) SESSION III Chair: Marc Rogers

F R I D A Y

1:45 pm STIMULATING WITH LIGHT. Keynote Speaker: Pancho Bezanilla 2:30 pm

NOVEL SMALL MOLECULE NAV CHANNEL BLOCKERS SELECTIVELY TARGETING NOCICEPTORS FOR THE TREATMENT OF COUGH, PAIN AND ITCH. James Ellis 3:00 pm KNOTTIN-ANTIBODY FUSION PROTEINS (KNOTBODIES): A NOVEL BIOLOGICS CLASS TARGETING KV1.3 (AUTOIMMUNITY), NAV1.7 (CHRONIC PAIN) AND ASIC1A (STROKE). Aneesh Karatt-Vellatt 3:30 pm COFFEE BREAK SESSION IV Chair: James Ellis 4:00 pm PHARMACOLOGY OF VOLTAGE SENSOR TARGETING NAV1.6 INHIBITORS. Sam Goodchild 4:30 pm APPLICATION OF HIGH-THROUGHPUT AUTOMATED PATCH-CLAMP TECHNIQUES TO STUDY ION CHANNEL FUNCTION IN CULTURED PRIMARY RAT CORTICAL AND HYPOTHALAMIC NEURONS. Fern Toh 5:10 pm CLOSING REMARKS Thomas Binzer Structural characterization of complex biomolecular systems increasingly relies on novel integrative modeling methods that combine data from various experimental and computational techniques. This Workshop will focus on an initiative to create an interoperating network of structural biology model and data repositories to enable the archiving of integrative structural models and associated experimental data. This effort follows the recommendations of the wwPDB Hybrid/Integrative Methods Task Force ( https://www.wwpdb.org/task/hybrid ).  The goals of the Workshop are to: • Outline the issues involved in developing and maintaining data standards in the different communities  • Outline the issues involved in efficient standards based data exchange among the network of structural biology model and data repositories  • Make a plan for how best to address the recommendations for data standards and data exchange  • Create a process for sustained communication among different communities • Prepare for writing a white paper summarizing the outcome of the Workshop  As a wwPDB activity, our goal is to facilitate the continued development and usage of the current PDB-Dev repository for integrative models ( https://pdb-dev.wwpdb.org ), so that the integrative structures archived in PDB-Dev can ultimately become part of the PDB. To do this, we need to define the mechanisms by which all experimental methods used by inte- Working Towards Federating Structural Models and Data Satellite Meeting 8:30 am - 6:00 pm, Room 301/302

Sponsored by Sophion Bioscience; Nanion Technologies; Metrion Biosciences; SB Drug Discovery; and Evotec AG

Ion channels are an important class of therapeutic drug targets, and mutations in ion channel genes are found to be responsible for an increasing number of diseases. While conventional electrophysiological techniques permit the most detailed and direct study of ion channel function, they are limited due to the manual nature of the method and their low throughput. Because of this, ion channels remain an underrepresented target class for drug discovery. The advent of higher throughput automated electrophysiology systems has begun to change the face of ion channel drug discovery. Since the inaugural “Drug Discovery for Ion Channels” satellite meeting, there have been many advances in ion channel drug discovery including new instrumentation and techniques. This year’s meeting will highlight presentations from users of automated electrophysiology instrumentation as well as other speakers in the field of ion channel drug discovery, including several academic speakers. 8:00 am REGISTRATION 8:45 am WELCOME AND OPENING REMARKS Niels Fertig SESSION I Chair: David Dalrymple 9:00 am NPY, HCN1 AND STRESS RESILIENCE. Keynote Speaker: William Colmers 9:45 am USE OF AUTOMATED PATCH CLAMP PLATFORMS TO SUPPORT ION CHANNEL DRUG DISCOVERY. Stephen Hess 10:15 am SUCCESSFUL DEVELOPMENT OF STATE-DEPENDENT VOLTAGE-GATED ION CHANNEL MODULATORS WITH IN VIVO EFFICACY USING AUTOMATED PATCH CLAMP ASSAYS FOR PRIMARY TARGET POTENCY, SPECIES AND GENE FAMILY SELECTIVITY, AND CARDIAC SAFETY. Marc Rogers 10:45 am COFFEE BREAK SESSION II Chair: Stephen Hess 11:15 am PROTX-II INHIBITS NAV1.7 THROUGH AN ELECTROSTATIC GATING MODULATION MECHANISM. Tianbo Li 11:45 am TARGET BASED SCREENING ON NAV CHANNELS IN SPIKING HEK CELLS, USING OPTICAL STIMULATION AND RECORDING. Hongkang Zhang 12:15 pm ASSESSMENT OF DIVERSE AND FOCUSSED LIBRARIES FOR ION CHANNEL SCREENING. David Dalrymple

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