Biophysical Society 63rd Annual Meeting | Program Guide

618-Pos Board B393 P-GLYCOPROTEIN ACTIVITY IS NON-MONOTONICALLY MODULATED BY TRANSMEMBRANE VOLTAGE. Thomas B.H. Schroeder , Haiyan Liu, David Sept, Khyati Kapoor, Divya K. Rao, Suresh V. Ambudkar, Michael Mayer 619-Pos Board B394 CONFORMATIONAL COUPLING TO ASYMMETRIC ATP HYDROLYSIS IN THE TRANSPORT CYCLE OF P-GLYCOPROTEIN. Sepehr Dehghani-Ghahnaviyeh , Karan Kapoor, Emad Tajkhorshid 620-Pos Board B395 LIPID-MEDIATED INHIBITION MECHANISM OF P-GLYCOPROTEIN.  Karan Kapoor , Shashank Pant, Emad Tajkhorshid 621-Pos Board B396 MECHANISTIC STUDY OF A PEPTIDASE CONTAINING ABC-TRANSPORTER, EMPLOYING MICROSECOND LEVEL MOLECULAR DYNAMICS SIMULA- TIONS AND ENHANCED SAMPLING TECHNIQUES. Dylan S. Ogden , Vivek Govind Kumar, Mahmoud Moradi 622-Pos Board B397 ELECTROSTATIC LOCK IN THE TRANSPORT CYCLE OF THE MULTIDRUG RESISTANCE TRANSPORTER EMRE.  Josh V. Vermaas , Susan L. Rempe, Emad Tajkhorshid 623-Pos Board B398 SPONTANEOUS PHOSPHOLIPID BINDING TO THE BACTERIAL FLIPPASE MSBA. Po-Chao Wen , Pius Padayatti, Qinghai Zhang, Emad Tajkhorshid 624-Pos Board B399 MAPPING MEMBRANE PROTEIN COMPLEX ASSEMBLY PATHWAYS IN LIVE CELLS WITH PROGRESSIVE ACCEPTOR PHOTOBLEACHING.  Michael P. Dalton , Ellen E. Cho, Marsha P. Pribadi, Deo R. Singh, Seth L. Robia 625-Pos Board B400 PHOTOCYCLE AND ABNORMAL ACTIVITY OF THE DUAL CHROMOPHORE PROTON PUMP ARCHAERHODOPSIN-4 WITH AND WITHOUT THE SEC- OND CHROMOPHORE. Xiaoyan Ding, Chao Sun, Haolin Cui, Sijin Chen, Xinyi Dong, Xinru Meng, Ming Wang, Yanan Yang, Weimin Liu, Qixi Mi, Xiao He, Anthony Watts, Xin Zhao 626-Pos Board B401 WHAT IS YOUR MACHINE REALLY DOING? SYSTEMATIC EXPLORATION OF ALTERNATIVE MECHANISMS AS APPLIED TO TRANSPORT. August George , Michael Grabe, John M. Rosenberg, Daniel M. Zuckerman 627-Pos Board B402 COMPARATIVE ANALYSIS OF PULSED EPR DISTANCE MEASUREMENTS IN AN E. COLI COBALAMIN TRANSPORTER IN CELLS VERSUS ISOLATED OUTER MEMBRANES REVEALS NOVEL CONFORMATIONAL CHANGES DEPENDENT ON THE NATIVE ENVIRONMENT. David Nyenhuis , Thushani Nilaweera, David S. Cafiso 628-Pos Board B403 AN APPROACH FOR EXPLORING NOVEL CONFORMATIONAL STATES AND MEMBRANE ORGANIZATION OF BTUB IN WHOLE CELLS USING EPR SPECTROSCOPY. Thushani D. Nilaweera , David A. Nyenhuis, Robert K. Nakamoto, David S. Cafiso 629-Pos Board B404 LIVE-CELL FRET BIOSENSORS FOR HIGH-THROUGHPUT SCREENING TAR- GETING THE SERCA2A/PLB COMPLEX. Dan Stroik , Samantha Yuen, Evan Kleinboehl, Kevyn Janicek, Tory Schaaf, Razvan Cornea, David Thomas 630-Pos Board B405 THE PHOSPHOLAMBAN PENTAMER FUNCTIONALLY INTERACTS WITH THE SARCOPLASMIC RETICULUM CALCIUM PUMP SERCA. John Paul Glaves, Joseph O. Primeau, L. Michel Espinoza-Fonseca, M. Joanne Lemieux, Howard S. Young

631-Pos Board B406 SINGLE-MOLECULE STUDIES OF ATP BINDING TO THE SODIUM PUMP. Su- shi Madhira, Don C. Lamb, Promod R. Pratap 632-Pos Board B407 THE BRINE SHRIMP’S FIGHT AGAINST HYPERSALINE ENVIRONMENTS RE- QUIRES A NA/K PUMP WITH REDUCED STOICHIOMETRY. Dylan J. Meyer, Victoria C. Young, Jessica Eastman, Jessica Drenth, Abigail Benson, Kerri Spontarelli, Craig Gatto, Pablo Artigas 633-Pos Board B408 EXTRACELLULAR NA + INTERACTIONS IN THE WT HNA + /K + ATPASE ALPHA 3 AND ALTERNATING HEMIPLEGIA OF CHILDHOOD. Cristina Moreno Vadillo , Miguel Holmgren 634-Pos Board B409 EXPRESSION OF THE NA + /K + -ATPASE SUBUNITS IN ADULT MOUSE BRAIN ANALYZED BY SINGLE-CELL RNA-SEQ PROFILING. Song Jiao , Cristina Moreno Vadillo, Miguel Holmgren 635-Pos Board B410 THE SINGLE CHANNEL CONFIGURATION OF NA/K PUMP. Pengfei Liang , Jason Mast, Wei Chen Cellular Signaling and Metabolic Networks (Boards B411 - B425) 636-Pos Board B411 NEW TOOLS FOR BACTERIAL BIOFILM ELECTROPHYSIOLOGY.  Alan L. Gillman , Joseph W. Larkin, Edgar Gutierrez, Jordi Garcia-Ojalvo, Alex Groisman, Gurol M. Suel 637-Pos Board B412 PREDICTING TGF-Β-INDUCED EPITHELIAL-MESENCHYMAL TRANSITION USING DATA ASSIMILATION. Mario J. Mendez , Matthew J. Hoffman, Eliza- beth M. Cherry, Christopher A. Lemmon, Seth H. Weinberg 638-Pos Board B413 SIGNALLING GROWTH THROUGH LIPID KINASES. Sanjeev Sharma , Swarna Mathre, Visvanathan Ramya, Dhananjay Shinde, Padinjat Raghu 639-Pos Board B414 DYNAMINE-RELATED PROTEIN 1 (DRP1) CONTRIBUTES TO HYPERTENSIVE CARDIAC HYPERTROPHY AND FIBROSIS IN VIVO AND IN VITRO MOD- EL. Prottoy Hasan 640-Pos Board B415 QUANTIFICATION OF DYNAMIC GLUCOKINASE REGULATION IN ISLETS US- ING A HOMOTRANSFER FRET REPORTER. Shenq Huey Wong 641-Pos Board B416 PREDICTION OF METABOLITE CONCENTRATIONS, RATE CONSTANTS AND POST-TRANSLATIONAL REGULATION OF NEUROSPORA CRASSA USING MAXIMUM ENTROPY OPTIMIZATIONS AND REINFORCEMENT LEARN- ING. William R. Cannon , Samuel R. Britton, Mikahl Banwarth-Kuhn, Mark Alber, Jennifer M. Hurley, Meaghan S. Jankowski, Jeremy D. Zucker, Douglas J. Baxter, Neeraj Kumar, Scott E. Baker, Jay C. Dunlap 642-Pos Board B417 TOWARD A MULTISCALE MODEL OF VALVULAR INTERSTITIAL CELLS: AN INTEGRIN-MEDIATED MECHANOTRANSDUCTION MODULE.  Daniel P. Howsmon , Michael S. Sacks 643-Pos Board B418 CHARACTERIZATION OF THE CONTRIBUTION OF RETINOIC ACID RECEP- TOR ISOFORMS IN THE SUPPRESSION OF CARDIAC HYPERTROPHY.  Lauren Parker , Ni Yang, Brian O’Rourke, D. Brian Foster

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