Biophysical Society 63rd Annual Meeting | Program Guide

Protein-Nucleic Acid Interactions I (Boards B147 - B171)

1031-Pos Board B133 DYNAMIC COUPLING OF THE AROMATIC ROTAMER CONFORMATION WITH THE BACTERIORHODOPSIN PHOTOCYCLE AS REVEALED BY THE CHEMICAL SHIFT ASSISTED QM/MM CALCULATIONS. Sijin Chen, Xiaoyan Ding, Chao Sun, Haolin Cui, Anthony Watts, Xiao He, Xin Zhao 1032-Pos Board B134 EXPLORING THE HYDROPHOBIC BARRIER OF HUMAN K2P CHANNEL TWIK1 WITH STEERED MD SIMULATIONS. Bharat Poudel , Rajitha R. Tatikonda, Juan M. Vanegas Transcription (Boards B135 - B146) 1033-Pos Board B135 NUCLEAR MYOSIN VI STABILIZES RNA POLYMERASE II IN TRANSCRIPTION FACTORIES. Yukti Hari Gupta, Natalia Fili, Alia dos Santos, Teng-Leong Chew, Jesse Aaron, Lin Wang, Christopher P. Toseland 1034-Pos Board B136 NUCLEAR MYOSIN VI REGULATES ESTROGEN RECEPTOR DRIVEN GENE EXPRESSION. Yukti Hari Gupta , Natalia Fili, Alia dos Santos, Teng-Leong Chew, Jesse Aaron, Lin Wang, Christopher P. Toseland 1035-Pos Board B137 DETERMINING DYNAMICS OF RNA POLYMERASE ELONGATION AND PAUSING USING NANOPORE TWEEZERS.  Ian C. Nova , Jonathan M. Craig, Andrew H. Laszlo, Abhishek Mazumder, Henry Brinkerhoff, Ian M. Der- rington, Matthew T. Noakes, Jonathan W. Mount, Jesse Huang, Jasmine Bowman, Richard H. Ebright, Jens H. Gundlach 1036-Pos Board B138 RNA ISOFORM IDENTIFICATION VIA SEQUENTIAL HYBRIDIZATION AND STRAND DISPLACEMENT BASED AMPLICATION IN THE CAENORHABDITIS ELEGANS GERMLINE. Gable M. Wadsworth , Harold D. Kim 1037-Pos Board B139 G-QUADRUPLEX FORMING SEQUENCE MODULATED TRANSCRIP- TION. Chun-Ying Lee , Christina McNerney, Kevin Ma, Sua Myong 1038-Pos Board B140 TRANSCRIPTION MACHINE STUDIED IN A NUTSHELL ON T7 RNA POLY- MERASE MECHANOCHEMISTRY, FIDELITY CONTROL, AND BURSTING ACTIVITY.  Jin Yu 1039-Pos Board B141 TFIIH GENERATES A SIX-BASE-PAIR OPEN COMPLEX DURING EUKARY- OTIC TRANSCRIPTION INITIATION. Eric A. Galburt , Eric J. Tomko, James Fishburn, Steven Hahn 1040-Pos Board B142 NUCLEAR NDP52 - A PUTATIVE TRANSCRIPTION REGULATOR. Alia dos Santos , Lin Wang, Christopher P. Toseland 1041-Pos Board B143 TRAVEL AWARDEE CHARACTERIZING TRANSIENT INTERMEDIATES IN PRODUCTIVE RNAP TRANSCRIPTION INITIATION. Claire E. Evensen , Kate Henderson, M. Thomas Record 1042-Pos Board B144 EFFECTS OF DISCRIMINATOR CHANGES ON OPEN COMPLEX FORMATION, STABILIZATION, AND TRANSCRIPTION INITIATION. Hao-Che Wang 1043-Pos Board B145 TRAVEL AWARDEE REGULATION OF MYCOBACTERIAL RNA POLYMERASE PROMOTER ESCAPE KINETICS BY TRANSCRIPTION FACTORS CARD AND RBPA. Drake Jensen , Ana Ruiz Manzano, Christina L. Stallings, Eric A. Galburt 1044-Pos Board B146 TRANSCRIPTION FACTOR REGULATION OF RNA POLYMERASE’S TORQUE GENERATION CAPACITY. Jie Ma, Chuang Tan , Xiang Gao, Robert M. Ful- bright, Jeffrey W. Roberts, Michelle D. Wang

M O N D A Y

1045-Pos Board B147 PREDICTING DIFFUSION COEFFICIENTS OF DNA-PROTEIN COMPLEXES BY CONVEX HULL MODELLING. Miles Lee , Quan Wang 1046-Pos Board B148 LOOPS ENHANCE TRANSCRIPTIONAL ROADBLOCKS. Wenxuan Xu , Yan Yan, David D. Dunlap, Laura Finzi 1047-Pos Board B149 DNA BENDING/UNBENDING RATES REVEALED FOR NONSPECIFIC AR- CHITECTURAL DNA-BINDING PROTEIN YNHP6A. Viktoriya Zvoda , Manas K. Sarangi, Molly Nelson Holte, Nicole A. Becker, Justin P. Peters, Louis J. Maher, III, Anjum Ansari 1048-Pos Board B150 DIRECT OBSERVATION OF DNA TARGET SEARCHING AND CLEAVAGE BY CRISPR-CAS12A. Yongmoon Jeon, You Hee Choi, Yunsu Jang, Jiyoung Gu, Cherlhyun Jeong , Sanghwa Lee, Sangsu Bae 1049-Pos Board B151 ELECTRIC-FIELD-DRIVEN TRANSLOCATION OF SSDNA THROUGH HYDRO- PHOBIC NANOPORES. Taylor Haynes , Iain P. S. Smith, Jayne Wallace, Jemma Trick, Mark S. Sansom, Syma Khalid 1050-Pos Board B152 TIN2 IS AN ARCHITECTURAL PROTEIN STABILIZING TRF1 AT TELO- MERE. Hai Pan , Saroj Dangi, Parminder Kaur, Pengyu Hao, Keith Weninger, Robert Riehn, Patricia Opresko, Hong Wang 1051-Pos Board B153 SOLUTION DYNAMICS IN HISTONE-BASED ARCHAEAL CHROMATIN.  Samuel Bowerman , Karolin Luger, Jeff Wereszczynski 1052-Pos Board B154 MUTATION OF THE DEAD-BOX ATPASE PRP5 IMPACTS DYNAMICS OF THE RECA-LIKE DOMAINS AND BRANCH SITE USAGE DURING PRE-MRNA SPLICING. David H. Beier, Tucker J. Carrocci, Aaron A. Hoskins 1053-Pos Board B155 BRIDGE HELIX OF CAS9 IMPACTS TARGET DNA CLEAVAGE. Rakhi Rajan 1054-Pos Board B156 MOLECULAR DYNAMICS SIMULATIONS OF RNA-RECOGNITION MOTIF COMPLEXED WITH CAC-CONTAINING RNA. Shan Chang , Hang Shi, Ren Kong 1055-Pos Board B157 INVESTIGATING THE EFFECT OF VARIOUS FMRP ISOFORMS ON MI- CRORNA BIOGENESIS.  Joshua A. Imperatore , John Roth, Mihaela Rita Mihailescu 1056-Pos Board B158 MISMATCH RECOGNITION BY MSH2-MSH6: ROLE OF STRUCTURE AND DYNAMICS. Zane Lombardo , Yan Li, Meera Joshi, Manju M. Hingorani, Ishita Mukerji 1057-Pos Board B159 MOLECULAR SIMULATIONS DISCERN THE COOPERATIVE BINDING OF HUMAN BRAHMA-RELATED GENE 1 BROMODOMAIN AND AT-HOOK REGIONS IN DNA BINDING. Stefania Evoli , Jeffery M. Wereszczynski 1058-Pos Board B160 STUDYING NUCLEOSOME ASSEMBLY VIA FRET. Caitlin Aguirre , Loiselle Gonzalez Baez, Elizabeth Jamieson, Megan E. Nunez 1059-Pos Board B161 WILD-TYPE FUS RESCUES ALTERED RNA BINDING OF ALS-LINKED FUS MUTANT. Kevin Rhine , Jaya Sarkar, Amirhossein Ghanbari Niaki, Xinyi Cai, Gabby Vidaurre, Sua Myong

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