Biophysical Society 65th Annual Meeting Program Guide

1612-Pos B oard B214 PRIOR FREEZING IN LIQUID NITROGEN HAS MINIMAL IMPACT ON THE CONTRACTILE PROPERTIES OF CHEMICALLY PERMEABILIZED HUMAN MYOCARDIUM. Faruk H. Moonschi , Ashley M. White, Gregory N. Mil- burn, Dylan F. Colli, Emma J. Birks, Kenneth S. Campbell 1613-Pos B oard B215 USING A GENETIC ALGORITHM TO PARAMETERIZE A MATHEMATICAL MODEL OF A PORCINE VENTRICULAR CARDIOMYOCYTE. Taylor K. Pullinger , Matthew Amoni, Itziar Irurzun-Arana, Karin R. Sipido, Eric A. Sobie 1614-Pos B oard B216 AGE-ASSOCIATED ION CHANNEL LOCALIZATION AND EXPRESSION CHANGES REGULATE CARDIAC SODIUM GAIN-OF-FUNCTION. Madison B. Nowak , Steven Poelzing, Seth H. Weinberg 1615-Pos B oard B217 FINITE-ELEMENT MODELING OF PARAMETRICALLY-DEFINED CARDIAC IN- TERCALATED DISK NANODOMAIN STRUCTURE. Nicolae Moise , Heather L. Struckman, Celine Dagher, Rengasayee Veeraraghavan, Seth H. Weinberg 1616-Pos B oard B218 SPATIAL-TEMPORAL PATTERNS OF EARLY AFTERDEPOLARIZATIONS UNDERLYING T-WAVE ABNORMALITIES IN A TISSUE MODEL OF THE PURKINJE-VENTRICULAR SYSTEM. Mengya Yuan , Pan Li 1617-Pos B oard B219 DIFFERENTIAL ROLES OF CALCIUM-ACTIVATED AND CALCIUM-INHIBITED ADENYLYL CYCLASE ISOFORMS IN THE REGULATION OF SAN AUTOMATIC- ITY. Lu Ren , Phung Thai, Raghavender R. Gopireddy, Valeriy Timofeyev, Xiao-Dong Zhang, Alana C. Conti, Manuel F. Navedo, Nipavan Chiamvi- monvat 1618-Pos B oard B220 PKA AND CAMKII SIGNALING SYNERGISTICALLY PROMOTES ATRIAL ARRHYTHMIA IN POPULATIONS OF HUMAN ATRIAL TISSUES. Haibo Ni , Xianwei Zhang, Stefano Morotti, Eleonora Grandi 1619-Pos B oard B221 QUANTIFYING THE ARRHYTHMOGENIC EFFECTS OF SUBCELLULAR STRUCTURAL VARIATIONS IN A THREE-DIMENSIONAL MODEL OF THE HUMAN ATRIAL MYOCYTE. Xianwei Zhang , Haibo Ni, Stefano Morotti, Daisuke Sato, William E. Louch, Andrew G. Edwards, Eleonora Grandi TRP Channels (Boards B222 - B231) 1620-Pos B oard B222 TEMPERATURE SENSITIVITY IN THE TRPM8 CHANNEL IS HARBORED AT THE C-TERMINAL DOMAIN. Karen Castillo , Ignacio Diaz-Franulic, Jona- than Canan, Fernando D. Gonzalez-Nilo, Ramon Latorre 1621-Pos B oard B223 TRPV1 ENHANCES CCK SIGNALING IN VAGAL AFFERENT NEURONS. Rachel A. Arnold , James Peters 1622-Pos B oard B224 DISEASE-RELATED TRPM3 MUTATIONS RENDER THE CHANNEL OVERAC- TIVE VIA DIFFERENT MECHANISMS. Siyuan Zhao , Yevgen Yudin, Tibor Rohacs 1623-Pos B oard B225 DUAL EFFECTS OF PHOSPHATIDYLINOSITOL ON TRPV1 REGULATION INVOLVE FUNCTIONALLY DISTINCT BINDING SITES. Aysenur T. Yazici , Eleonora Gianti, Marina A. Kasimova, Vincenzo Carnevale, Tibor Rohacs 1624-Pos B oard B226 ATOMISTIC AND DYNAMIC DETAILS OF THE GATING MECHANISM OF THE TETHERED MECHANOSENSITIVE ION CHANNEL NOMPC. Yang Wang, Yifeng Guo, Guanluan Li, Chunhong Liu, Lei Wang, Aihua Zhang, Zhiqiang Yan, Chen Song

1625-Pos B oard B227 GATING OF TRPV5 CHANNEL ACTIVITY BY PHOSPHORYLATION AND EXOGENOUS LIGANDS. Edwin C. Fluck , Taylor Hughes, Ruth Pumroy, Vera Moiseenkova-Bell 1626-Pos B oard B228 ACTIVATION AND INHIBITION OF ASSAY-READY TRPA1 AND TRPV CELLS: AN AUTOMATED PATCH CLAMP STUDY. Andrea Bruggemann , Tom A. Goetze, András Horváth, Ilka Rinke, Nadine Becker, Alison Obergrussberg- er, Lukas Focke, Oliver Wehmeier, Ralf Schwandner, Niels Fertig 1627-Pos B oard B229 TRPM7 PERMEANT DIVALENT METAL CYTOTOXICITY DURING MAGNE- SIUM DEPLETION AND LOADING. Alayna A. Mellott, Jananie Rockwood , Charles T. Luu, J. Ashot Kozak 1628-Pos B oard B230 MECHANISM OF PRAZIQUANTEL ACTION AT A TRANSIENT RECEPTOR POTENTIAL CHANNEL. Sang-Kyu Park, Lukas Friedrich, Nawal Yahya, Claudia Rohr, David Maillard, Friedrich Rippmann, Thomas Spangenberg, Jonathan S. Marchant 1629-Pos B oard B231 STRUCTURE OF THE ANCESTRAL TRPY1 CHANNEL FROM SACCHARO- MYCES CEREVISIAE REVEALS MECHANISMS OF LIPID AND CALCIUM MODULATION. Tofayel Ahmed , Collin Nisler, Edwin C. Fluck, Marcos M. Sotomayor, Vera Moiseenkova-Bell Ligand-gated Channels II (Boards B232 - B245) 1630-Pos B oard B232 MOLECULAR DETERMINANTS OF NEUROPEPTIDE POTENCY AT FMRF-AM- IDE GATED SODIUM CHANNELS FROM THE DEG/ENAC FAMILY. Mowgli Dandamudi , Timothy Lynagh 1631-Pos B oard B233 VALIDATION OF AN ASIC1A LIGAND-GATED ASSAY ON AN AUTOMATED PATCH CLAMP PLATFORM AND ITS USE FOR NOVEL LIGAND SCREEN- ING. Marc Rogers , John Ridley, Ian Witton, Raymond Tang, Robert W. Kirby 1632-Pos B oard B234 DETERMINING THE TOPOLOGY OF THE ACID-SENSING ION CHANNEL INTRACELLULAR DOMAINS. Tyler A. Couch , Kyle Berger, Dana Kneisley, Matthew L. Rook, Tyler W. McCullock, Paul J. Kammermeier, David M. B oard B235 CHARACTERIZING CONFORMATIONAL CHANGES OF ASIC1A DURING GATING AND PEPTIDE MODULATION. Stephanie A. Heusser , Zeshan P. Sheikh, Christian B. Borg, Iacopo Galleano, Stephan A. Pless 1634-Pos B oard B236 ASIC ACTIVATION MECHANISMS DELINEATED THROUGH GENETIC CODE EXPANSION. Matthew L. Rook , Tyler A. Couch, Jackson Hernandez, Alison J. Frontier, David M. MacLean 1635-Pos B oard B237 DEVELOPMENT AND VALIDATION OF ASIC1A LIGAND-GATED ION CHAN- NEL DRUG DISCOVERY ASSAYS ON AUTOMATED PATCH CLAMP PLAT- FORMS. Marc Rogers , SamManyweathers, Tom Götze, Nadine Becker, Ilka Rinke, Michael George, Alison Obergrussberger 1636-Pos B oard B238 DETERMINING ARACHIDONIC ACID INTERACTION SITES FOR ACID-SENS- ING ION CHANNELS USING MD SIMULATIONS. Anna Ananchenko , Maria Musgaard MacLean 1633-Pos

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