Biophysical Society 65th Annual Meeting Program Guide

Protein Structure and Conformation I (Boards B1 - B21) 67-Pos B oard B1 THE INFLUENCE OF GLYCOSYLATION ON THE INTERACTION OF THE SARS- COV-2 SPIKE PROTEIN RECEPTOR BINDING DOMAIN WITH THERAPEUTIC CANDIDATES. Bradley Harris, Yihan Huang, Giovanni Lara, Shiaki Minami, Matthew Kenaston, Seongwon Jung, Yongao Xiong, Karen McDonald, Somen Nandi, Priya Shah, Roland Faller 68-Pos B oard B2 RAPID CHARACTERIZATION OF SARS COV2 PROTEINS WITH SCATTERING METHODS. Greg L. Hura 69-Pos B oard B3 EXPLORING THE ROLE OF GLYCANS IN THE INTERACTION OF SARS-COV-2 RBD AND HUMAN RECEPTOR ACE2. Kien Nguyen , Srirupa Chakraborty, Rachael A. Mansbach, Pedro D. Manrique, Bette Korber, Sandrasegaram Gnanakaran 70-Pos B oard B4 FACTORS THAT AFFECT THE BINDING OF THE N-TERMINAL HELIX OF HUMAN ACE2 TO SPIKE PROTEIN OF SARS-COV2. Anirban Das , Vicky Vish- vakarma, Ankur Gupta, Simli Dey, Arpan Dey, U S. Sandra, Ullas Kolthur, Mitradip Das, Krishna K. Vishwakarma, Ravindra Venkatramani, Sudipta Maiti 71-Pos B oard B5 TOPOGRAPHY, SPIKE DYNAMICS AND NANOMECHANICS OF INDIVIDUAL NATIVE SARS-COV-2 VIRIONS. Balint Kiss, Zoltán Kis, Bernadett Pályi, Miklós S. Kellermayer 72-Pos B oard B6 ENERGETICS OF OPENING FOR THE GLYCOSYLATED AND UNGLYCOSYL- ATED FORMS OF THE SARS-COV-2 S-PROTEIN TRIMER. Yui Tik Pang , Atanu Acharya, Diane L. Lynch, James C. Gumbart 73-Pos B oard B7 CORONAVIRUS PATHOGENICITY IS DETERMINED BY STABILITY OF THE SPIKE PROTEIN OPEN CONFORMATION. Josiah Bones , Ben Corry 74-Pos B oard B8 AN INTEGRATIVE MD SIMULATION AND NETWORK ANALYSIS APPROACH TO STUDY GLYCOSYLATION OF SPIKE IN SARS-COV-2. Mahdi Ghorbani , Bernard R. Brooks, Jeffery B. Klauda 75-Pos B oard B9 STRUCTURES OF CAPSID AND CAPSID-ASSOCIATED TEGUMENT COMPLEX INSIDE THE EPSTEIN-BARR VIRUS. Wei Liu , Yanxiang Cui, Caiyan Wang, Zi- hang Li, Danyang Gong, Xinghong Dai, Guo-Qiang Bi, Ren Sun, Hong Zhou 76-Pos B oard B10 A COMBINED HDX-MS AND MD SIMULATION APPROACH TO IDENTIFY POTENTIAL DRUGGABLE REGIONS IN THE NS5 PROTEIN OF THE DENGUE VIRUS SEROTYPE 2. Juliet O. Obi , Daniel J. Deredge 77-Pos B oard B11 COOPERATIVE DYNAMICS OF REC-NUC LOBES PRIME CAS12A FOR DNA PROCESSING. Aakash Saha , Pablo R. Arantes, Rohaine Hsu, Yogesh B. Narkhede, Martin Jinek, Giulia Palermo 78-Pos B oard B12 STRUCTURAL AND BIOCHEMICAL ANALYSIS OF A METHYLATION SENSI- TIVE CAS9. Anuska Das 79-Pos B oard B13 DNA-INDUCED ALLOSTERIC CONTROL REGULATES ACTIVATION OF CAS12A. Pablo R. Arantes , Aakash Saha, Martin Jinek, Giulia Palermo

80-Pos B oard B14 DYNAMICAL BEHAVIOR OF THE CAT DOMAIN FROM CRE RECOMBI- NASE, IN THE ABSENCE OF AND WITH THE CIS INTERACTION OF THE N HELIX. Marco A. Ramírez 81-Pos B oard B15 DYNAMIC CONSEQUENCES OF SPECIFICITY WITHIN THE CYTIDINE RE- PRESSOR DNA-BINDING DOMAIN. Jenaro Soto , Colleen Moody, Donald F. Senear, Melanie J. Cocco 82-Pos B oard B16 A BIOPHYSICS UNDERGRADUATE RESEARCH STORY FROM THE UNIVER- SITY FOR THE DEAF AND HARD OF HEARING. Tugba G. Kucukkal 83-Pos B oard B17 NOVEL ANTI-REPRESSION MECHANISM OF H-NS PROTEINS BY PHAGE’S “EARLY PROTEINS”. Fredj Ben Bdira , Liang Qing, Alexander N. Volkov, Mandy Erkelens, Remus T. Dame 84-Pos B oard B18 2.09 Å RESOLUTION STRUCTURE OF E. COLI HIGBA TOXIN-ANTITOXIN COMPLEX REVEALS AN ORDERED DNA-BINDING DOMAIN AND INTRINSIC DYNAMICS IN ANTITOXIN. Pankaj Jadhav 85-Pos B oard B19 ENSEMBLE SWITCHING OF THE DNA-BINDING DOMAIN OF HUMAN FOXP1. Narendar Kolimi , Exequiel Medina, César Ramírez-Sarmiento, Hugo Sanabria, Jorge Babul 86-Pos B oard B20 STRUCTURE OF THE ATP-FREE MRE11-RAD50 DNA DAMAGE REPAIR COMPLEX BOUND TO DNA SUBSTRATES. Mahtab Beikzadeh , Marella Canny, Michael Latham 87-Pos B oard B21 STUDYING THE INTERACTION MECHANISM OF AZURIN-DERIVED PEPTIDE P28 AND TUMOR SUPPRESSOR P53. Jing Yang , Yifan Zeng, Junwen Xiong, Meng Gao, Yongqi Huang Protein Structure, Prediction, and Design (Boards B22 - B37) 88-Pos B oard B22 THE TRADE-OFF BETWEEN THERMOSTABILITY AND FUNCTION IN DE- SIGNED DNA-BINDING PROTEINS. Lauren A. Verheyden, Lily A. Schum- acher, Andrew Bigler, Natali A. Gonzalez, Emily Hamlin, Parwana Z. Khazi, Michelle E. McCully 89-Pos B oard B23 PREDICTION OF AMPHIPATHIC HELIX - MEMBRANE INTERACTIONS WITH ROSETTA. Alican Gulsevin , Jens Meiler 90-Pos B oard B24 HIGH RESOLUTION CRYO-EM STRUCTURE OF THE ESPA FILAMENT FROM EPEC. Bronwyn Lyons 91-Pos B oard B25 COMPLETING THE PARTIALLY RESOLVED COMPLEX CRYSTAL STRUC- TURE OF AURORA KINASE A / N-MYC BY MOLECULAR MODELING. Pinar Altiner , Suleyman Selim Çınaroglu, Emel Timucin 92-Pos B oard B26 EVOLUTIONARY MODELS OF FOLD-SWITCHING PROTEINS. Layne B. Frechette , Robert B. Best

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